DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and tn

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster

Alignment Length:	1606	Identity:	273/1606 - (16%)
Similarity:	470/1606 - (29%)	Gaps:	683/1606 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 CKLCSLRLVMPRILSCLHVFC-EDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQNRLSAVFIECP 224
            |.:|..|..:|::|.|.|.|| |.|::.:|                  |....|       ::||
  Fly    10 CCVCLDRYRIPKLLPCQHSFCMEPCMEGLV------------------DYVRRQ-------VKCP 49

  Fly   225 VCKQETPLGPKGIKALPCDYIVTNILDLSNLE---------SEHIV--CTSCKSKEEAISRCNDC 278
            .|:.|..:...|::|.|.:..:...|:| ::|         |..|:  |..| |::..:|.|..|
  Fly    50 ECRAEHRIPYNGVQAFPTNVTLQRFLEL-HIEITGELPDPTSGQIMERCGVC-SEKAYLSHCAHC 112

  Fly   279 ANFLCNGCDNAHKYMRCFENHHVVRIE------DLTKNVH---DKL-IIHKPVFCPQ----HVSE 329
            ...:|..|.:||.        .::|.|      .:.:::|   |.| ||.|.....|    .|:|
  Fly   113 EKKICEDCKSAHM--------DILRREITRFNSQIRRSLHRLQDSLAIIEKNTMSLQTNAISVTE 169

  Fly   330 NLKYYCFTCQVPTCNDCLLSDHKGSDHHYETATVA----EQAVRADLEETLSDTLKKADYCNDAG 390
            .:                       |..|:..|.|    ...::.:::..|:..|:......:
  Fly   170 EI-----------------------DEIYQRITKAIKDRSDQLKGEIDRYLAVELRNLTTLKE-- 209

  Fly   391 SNLGSALTELQSQHDTVRQQIEDAYKCYKRMLESIKDQMLNELGRL------HSDRELKIMDLMQ 449
             ||...:|.:.|..|||.:.:.:..:.....|...|:..|..:..|      ::|...::..|:.
  Fly   210 -NLDLEITNITSNCDTVDKYMNETVEWDDCELMDTKEIFLKTVEFLRHFEYENNDYSRRVRFLVS 273

  Fly   450 SMENTMGKLQHAAQFGQ-----RAVDKANSIEFLLLKPIISAQ------------CLNLMEQTPK 497
            ...|.:  :.:.|.||.     .:.....|:....|.|..:.|            .....:|..:
  Fly   274 IDPNQL--VMNLATFGDLNIAPHSTPSGGSVSSSHLAPPSALQPGLMRSKSDHRLATQFRQQEER 336

  Fly   498 CDINYQ-----LQFDSKPE-MFEQFAREMFGK------FQTDH-IDSSPKKLGMTQQL------- 542
            ...|.:     .:|..:|: ...|...:.:|:      ::.|: .:.|..:.|.:.:.
  Fly   337 SGYNDEPVLGGRKFGERPQRSATQANNDRYGRSGGDYDYENDYDNEGSSGRAGKSSRFRSRFVRS 401

  Fly   543 ---------QQQQQQQQQLQQQQHQ--------------------HQHQVQQQQHHHQQQQQQKQ 578
                     |||||:||:|::::.:                    ....||:.....::::::|.
  Fly   402 HQNDDSDSEQQQQQRQQELKERKDRVLDSEDVSRGQLSGIIRLSDCSRVVQRLADIGKEKKEKKS 466

  Fly   579 Q--------VQHQQQQQKLQLQ-QQQQHQHNS---NNLIVGHR---GSSSVQGRLTSAVFSPISL 628
            .        ||...|.||..:| |||::|.|:   ..|....|   ||||..|..||.
  Fly   467 DAAAAAQAAVQAAIQAQKAAMQRQQQKNQQNAADEEELARQKRKNAGSSSTGGAATST------- 524

  Fly   629 PSSLQSSFDGDT-----------------------------NSVMSNFSMMDSPPQPSSQQQ-LP 663
                 ||..|||                             ||..|......|..:.::::: :.
  Fly   525 -----SSGGGDTASDQRVAALKNRGGEESDGSSNQAASPVRNSAASTTRAEVSVNEANTEEEGVA 584

  Fly   664 SAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQQHQVQQQQ-QQQVLH------QPTSA-------- 713
            |....|::.::.:.:.:.   ::|.::::..:..|:::: .:::|:      ||||:
  Fly   585 SESSDSEEDEEVEDEDEE---EEVDEEEEQVEESVEEEEAPRELLNLPEEALQPTSSEVTEEEES 646

  Fly   714 ----------------------------------------------------------------- 713

  Fly   647 SSEYEEVTATESEEEQEEVEGRVIEIESQDLPVINVLPPENDIAHKVEESPVDHISNQELMEETD 711

  Fly   714 --------------------QSMPQQLGQLVAPQGIVQQAGHVNLN------------------- 739
                                :|.|....|:.|.:. .|::|..:.:
  Fly   712 KSTDESPEEEEEEEYTEEEIESKPPVSAQVAAVKK-TQRSGSSDSSASTESSASSAAAAAVAATS 775

  Fly   740 -----AGPGPNISINGLGAGGPPPSFSMLEYNISR--------------------LASLT----- 774
                 |.|..: |.|........||.|  .|:.:|                    .||.|
  Fly   776 TSATAAAPATS-SSNSTSQNAKAPSSS--RYSTARDTTAVPEKKPFVSRFLPQHSTASTTNGSAD 837

  Fly   775 --------------------ETMPDT--------------------------------------- 780
                                |:.|:|
  Fly   838 KKKAESSSSSEEETSSESESESEPETKAKSSATSSTTNTKSTPNSAASSTTAASSSTTSGSYRDR 902

  Fly   781 -------LNDALAVGGGAAGPVPNVVAQVPGGSAVTGA---AVVGASHAHQQQ------------ 823
                   .:|:.:...|.:.......:....||..||.   ||....|..:.:
  Fly   903 LEARRASRDDSSSTAAGRSSYATPSSSGYGSGSGTTGGRTRAVPAPHHTSESEDRYGSGTGSSYT 967

  Fly   824 ---------SQAVMPASAVTPTQPITLADILSGD-------------------QRALNNLQALAK 860
                     |..|...|..|||.........:||                   :..|...::..:
  Fly   968 SRFLNKSKSSAIVTQPSLSTPTASFDEDATGTGDDSDSRYGTGRSRYLAMKERRTRLARSRSSHQ 1032

  Fly   861 LGLNNNDFCMP--PAT-SPS--------------------------------------------- 877
            .|.::.|...|  |.| |||
  Fly  1033 FGNDDEDLDEPVSPTTVSPSAYLASRCAYSGYGSSDLSRSRSSHALKSRDNSPITDRGAGSSRSS 1097

  Fly   878 ----------------------------------------------------------------- 877

  Fly  1098 GLGGSSTTDSKDGEALSSWARYLKNKYGNKSSKDSAGSSGSARDTHAGSSTSSSAAASSSHAHGY 1162

  Fly   878 -------------------------LQSLNPIVGGVEDMGLNNF---------HAVAAPGTTSVV 908
                                     |:..|.:....:|...|..         .||||.|    :
  Fly  1163 GSGTSGSSGRSTASDVSRRLSLGLPLRQANELASSDDDGSKNGLGSPTSPTVAAAVAAAG----I 1223

  Fly   909 TGRNKATPMQIRCK-------FGSLGTAKGQFNSPHGFCLGVDEEIIVADTNNHRIEVFDKMGAL 966
            ||.....|.|:..:       .|..|:..|.|..|.|..:|.|..|:|||::|||::|||..|..
  Fly  1224 TGAAGTIPKQVYLRKRQQLFQLGGRGSEPGSFTWPRGLAVGPDNSIVVADSSNHRVQVFDSNGIF 1288

  Fly   967 KFQFGVAGKEEGQLWYPRKVAVMHNNGKFVVCDRGNERSRMQIFSKCGHFMRKI-----AIRYID 1026
            ..:||..|..||:......||| :..|::::.||.|.  |:|:....|.|:|..     |....:
  Fly  1289 VKEFGEYGNGEGEFDCLAGVAV-NRIGQYIIADRYNH--RIQVLDPQGRFLRAFGSQGTADGKFN 1350

  Fly  1027 IVAGLAVTAKGHIVAVDSVSPTVFVISEEGELVRWF-DC---SDYMREPSDIAIRD-NDFYVCDF 1086
            ...|:...|.|.|...|..:..|.|...:|..|..| .|   ...:..|..||:.: |...|.|.
  Fly  1351 YPWGVTTDALGFIYVCDKENHRVQVFQSDGSFVGKFGSCGRGEGQLEHPHYIAVSNTNRVIVSDS 1415

  Fly  1087 KGHCVAVFQDDGTFLYRIGNE-------KVTCFPNGIDISNAGDVLIGDSHGNRFHV-------- 1136
            ..|.:.:|..:|..|..:|.|       |   ||.|:.:.:.|.:.:.||..||..:
  Fly  1416 NNHRIQIFDVNGKVLSTVGGEGSDDGQFK---FPRGVAVDDQGYIFVADSGNNRIQIFNPDGSFL 1477

  Fly  1137 ACYSREGALQSEFECPHVKVSRCCGLKITSEGYVVTLAKNNHHVLV 1182
            ..:...|:..|||:...       |:.|.|.|.::...:.||.|.|
  Fly  1478 KTFGSWGSGDSEFKGLE-------GVAIMSNGNILVCDRENHRVQV 1516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	17/69 (25%)
		BBOX	321..360	CDD:237988	5/42 (12%)
		BBC	369..494	CDD:128778	23/147 (16%)
		NHL_brat_like	913..1186	CDD:271329	83/302 (27%)
		NHL repeat	936..972	CDD:271329	16/35 (46%)
		NHL repeat	983..1025	CDD:271329	13/46 (28%)
		NHL repeat	1028..1064	CDD:271329	10/36 (28%)
		NHL repeat	1068..1107	CDD:271329	11/39 (28%)
		NHL repeat	1112..1151	CDD:271329	12/46 (26%)
		NHL repeat	1157..1183	CDD:271329	8/26 (31%)
tn	NP_001137707.1	RING	9..54	CDD:238093	17/68 (25%)
		zf-B_box	94..>122	CDD:279037	8/28 (29%)
		iSH2_PI3K_IA_R	131..231	CDD:304922	23/125 (18%)
		NHL_TRIM71_like	1234..1517	CDD:271324	81/296 (27%)
		YncE	1253..>1517	CDD:225926	79/277 (29%)
		NHL repeat	1258..1297	CDD:271324	17/38 (45%)
		WD40 repeat	1261..1304	CDD:293791	18/42 (43%)
		NHL repeat	1305..1344	CDD:271324	12/41 (29%)
		WD40 repeat	1345..1377	CDD:293791	8/31 (26%)
		NHL repeat	1352..1388	CDD:271324	10/35 (29%)
		NHL repeat	1396..1436	CDD:271324	11/39 (28%)
		WD40 repeat	1402..1439	CDD:293791	11/36 (31%)
		NHL repeat	1445..1475	CDD:271324	8/29 (28%)
		WD40 repeat	1446..1485	CDD:293791	7/38 (18%)
		NHL repeat	1491..1517	CDD:271324	8/33 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447041
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.940