DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and Trim9

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster

Alignment Length:	431	Identity:	90/431 - (20%)
Similarity:	166/431 - (38%)	Gaps:	56/431 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SLDVTSSSSIGSET--SISSTGSTAIAGPSTLLDDSNSSGLGLVVDV-DSNGSSQELSSHGVTEL 142
            :||:.:..|.||..  :::..|:.:.||.:.|..:...:|.|....| :.||.....|||.....
  Fly    31 ALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGNGGGAGGGAAAPVTNPNGPGTRHSSHSSAAS 95

  Fly   143 DSLEDSCSGLMIKDGDKLCKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSF 207
            .:..::.|..:..|.|:..|              :.:|.|.....|...:|   |.|.|.:.:..
  Fly    96 TASSNTGSESVTSDQDQSDK--------------VSIFSEADSGVVCCSNT---SRPVSYAGTGL 143

  Fly   208 ---DGSEHQNRLSAVFIECPVCKQETPLGPKGIKALPCDYIVTNILDLSNLESEHIVCTSCKSKE 269
               .|:......:|..:.||:|::.......|::.||....:..|:| .....|.:.|..|::..
  Fly   144 LPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVD-RFCAREALRCQMCETDP 207

  Fly   270 EAISR-CNDCANFLCNGC-DNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHKPVFCPQHVSENLK 332
            :..|. |..|....|:.| :..|........|.:|:.....:        .:...|.:| .|.|.
  Fly   208 KVASLICEQCEIRYCDACRELTHPARGPLAKHTLVKPRGAAQ--------QRESVCGEH-EETLS 263

  Fly   333 YYCFTCQVPTCNDCLLSDHKGSDHHYETATVAEQAVRADLEETLSDTLKKADYCNDAGSNLGSAL 397
            .||.:|:.|.|..| :.:.:...|..::..|..:|.:.:|...|....:||       .:....:
  Fly   264 QYCLSCKAPACGLC-IGELRHQAHDVQSINVTCKAQKTELSHNLQQLSEKA-------RSTTEFI 320

  Fly   398 TELQSQHDTVRQQIEDAYK-----CYKRMLESIKDQMLNELGRLHSDRELKIMDLMQSMENTMGK 457
            ..|:...|.|.:...:..:     | :.::::|.|:....|..:..|::.||..|.....|..||
  Fly   321 QRLKGMSDKVTESCMEFERLVHAQC-EALIQAIHDRREYLLEAIRMDKDTKIRILKDQQSNCTGK 384

  Fly   458 LQHAA---QFGQRAVDKANSIEFLLLKPIISAQCLNLMEQT 495
            ||...   ||...|:.:.:|..||.    :.:..:|.:..|
  Fly   385 LQQTTGLIQFCIEALKETDSAAFLQ----VGSMLINRVTNT 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	14/74 (19%)
		BBOX	321..360	CDD:237988	11/38 (29%)
		BBC	369..494	CDD:128778	27/132 (20%)
		NHL_brat_like	913..1186	CDD:271329
		NHL repeat	936..972	CDD:271329
		NHL repeat	983..1025	CDD:271329
		NHL repeat	1028..1064	CDD:271329
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	2/5 (40%)
		zf-B_box	250..291	CDD:306989	11/42 (26%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	27/133 (20%)
		FN3	472..564	CDD:238020
		SPRY_PRY_TRIM67_9	561..735	CDD:293947
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447032
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840