DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-P26 and ftr67

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001034808.2	Gene:	ftr67 / 336567	ZFINID:	ZDB-GENE-060312-27	Length:	424	Species:	Danio rerio

Alignment Length:	479	Identity:	90/479 - (18%)
Similarity:	162/479 - (33%)	Gaps:	137/479 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 SGLMIKDGDKLCKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQN 214
            :|:.::.....|.:|...|..|..:.|.|.:|:.|::             |......:.|
Zfish     4 AGVFLEHDQFNCSICLDVLKDPVTIPCGHSYCKGCIK-------------NYWDQDDYLG----- 50

  Fly   215 RLSAVFIECPVCKQE-----------------TPLGPKGIKALPCDYIVTNILDLSNLESEHIVC 262
                 ...||.|:|.                 ..|...|:.|.|..       |.:..|...:.|
Zfish    51 -----IYGCPQCRQSFAPRPLLGRNTMLADVVEKLKKTGLHAGPAS-------DPTQAEPGDVEC 103

  Fly   263 TSCK-SKEEAISRCNDCANFLCNGCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHKPVFCPQH 326
            ..|. :|.:|...|..|....|......|.....|:.|   |:...:|.:.::|       |.:|
Zfish   104 DVCSGTKNKAFKSCLVCLASYCETHLQPHYESPAFQKH---RLASPSKKMQEQL-------CSRH 158

  Fly   327 VSENLKYYCFTCQVPTCNDCLLSDHKGSDHHYETATVAE------------QAVRADLEETLSDT 379
             .:.|:.:|.|.|...|..||..:|||.|....||.:.|            |....:.|:.|:|
Zfish   159 -DKLLEVFCRTDQQCICYLCLTDEHKGHDTVLATAEMNEKKNALLEMRRVSQRRIEEREKELAD- 221

  Fly   380 LKKADY-----CNDAGSNLGSALTELQSQHDTVRQQIEDAYKCYKR--------MLESIKDQMLN 431
            |::|..     ...|........|||....:..|.::::..:..:|        :|:.: :|.:.
Zfish   222 LRQATQMLTLSAQTALEESERVFTELVCSVERRRAEVKELIRGQERAAVSQAQTLLQQL-EQEIT 285

  Fly   432 ELGRLHSDRELKIMDLMQSMENTMGKLQHAAQFGQRAVDK---------------ANSIEF-LLL 480
            ||.:.|::    :.:|.|: ::.:..||:......:.|..               |...|| .||
Zfish   286 ELKKRHAE----LGELSQT-DDHIAFLQNCKSLCAQPVSVELPSITSEPNFTSVIAAVTEFQSLL 345

  Fly   481 KPIISAQCLNLMEQT----------PKCDI----------NYQLQFDSKPEMFEQFAREMFGKFQ 525
            :.:.....:::.|:.          ||.|:          ..|:.|.........|....||.
Zfish   346 EDVCQGGFVSISEKVDDVTIIQNTIPKTDLESNTAPVFGQTAQIPFTINVPTISVFPFSSFGS-- 408

  Fly   526 TDHIDSSPKKLGMTQQLQQQQQQQ 549
                    :..|..|:||.:::::
Zfish   409 --------RTQGPRQRLQPRRRRR 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	14/88 (16%)
		BBOX	321..360	CDD:237988	13/38 (34%)
		BBC	369..494	CDD:128778	26/153 (17%)
		NHL_brat_like	913..1186	CDD:271329
		NHL repeat	936..972	CDD:271329
		NHL repeat	983..1025	CDD:271329
		NHL repeat	1028..1064	CDD:271329
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
ftr67	NP_001034808.2	RING	15..57	CDD:302633	12/64 (19%)
		BBOX	150..189	CDD:197662	14/46 (30%)
		DUF2570	218..>294	CDD:305162	15/81 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR25462
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100