DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and Trim42

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001013977.1	Gene:	Trim42 / 301106	RGDID:	1359699	Length:	723	Species:	Rattus norvegicus

Alignment Length:	635	Identity:	121/635 - (19%)
Similarity:	215/635 - (33%)	Gaps:	203/635 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 DVTSSSSIGSETSISSTGSTA--IAGPSTLLDDSNSSGLGLVVDVDSNGSSQELSSHGVTELDSL 145
            :||.:...|...||.::..||  :....|.||:.               .:...|||.|..|
  Rat    98 NVTVTFRKGRLRSIRTSSKTALRVGSSDTQLDEP---------------KTMPASSHLVNHL--- 144

  Fly   146 EDSCSGLMIKDGDKLCKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGS 210
                          .|.:|:...:...:|.|.|..||.||:.:                     .
  Rat   145 --------------TCPMCNRLRLHSFMLPCNHSLCEKCLRQL---------------------Q 174

  Fly   211 EHQNRLSAVFI-ECPVCKQETPLGPKGIKALPCDYIVTNI--------------LDLSNLESEHI 260
            :|.......|| .||:|.:...:.......||.:|:...:              .|.|   |..|
  Rat   175 KHAEVTENFFILICPMCNRSHCMPYSHQMHLPENYLRGRLTKRYMQQHGYLKWRFDRS---SGPI 236

  Fly   261 VCTSCKSKEEAISRCNDCANFLCNGCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHKPVFCPQ 325
            :|..|:::..|..||..|...|||.|..|.......::|  |.::...::..:|:.||
  Rat   237 LCQVCRTRRIAYKRCVTCRLNLCNDCLKAFHSDVAMQDH--VFVDTSAEDQDEKICIH------- 292

  Fly   326 HVSENLKYYCFTCQVPTCNDCLLSDHKGSDHHYETATVAEQAVRADLEETLSDTLKKADYCNDAG 390
            |.|..:..||.:.....|..|.::.|.|                       .||:...|.|::..
  Rat   293 HPSSRINEYCRSDNQLLCAFCKIAFHNG-----------------------HDTVSLIDACSERS 334

  Fly   391 SNLGSALTELQSQHDTVRQQIED----------AYKCYKRMLESIKDQMLN---ELGRLHSDREL 442
            :.|.||:.:.::    ||.:|::          ::|..|   |:.:.::.|   :|..:..::|.
  Rat   335 AALFSAIAKFKA----VRYEIDNDLMEFNILKSSFKADK---EAKRKEVRNGFLKLRAILQEKEK 392

  Fly   443 KIMDLMQSME-------------NTM--GKLQHAAQFGQRAVDKANSIEFLLLKPIISAQCLNLM 492
            .||:.::::|             .||  .::.....:.:.|:.:...:.||....|:..|....:
  Rat   393 IIMEQIENLEVSRQKEIEKYVYITTMKVNEMDGLIAYSKEALKETGQVAFLQSAKILVDQIEEGI 457

  Fly   493 EQTPKCDINYQLQFDSK---PEMFEQFAREMFGKFQTDHIDSSPKKL---GMTQQLQQQQQQQQQ 551
            :.|.:.|  .||:..|.   |..|.:.:..:...|.|     .|||.   |.:...|.....:..
  Rat   458 QNTFRPD--PQLRLHSLHCIPLDFAELSSAIHELFPT-----GPKKTCSSGDSLPSQYPVHSEMM 515

  Fly   552 LQQQQHQHQHQVQQQQHHHQQQQQQKQQVQHQQQQQKLQLQQQQQHQHNSNNLI----VGHRGSS 612
            :.::.....|....||.:.:                             |::||    ...:|.:
  Rat   516 IARKVTFSTHSFGNQQIYQR-----------------------------SSSLISFNTANDKGKA 551

  Fly   613 SVQ--GRLTSAVFSPISLPSSLQS--SFDGDTNSVMSNFSMMDSPPQPSS 658
            .::  ||..||  :|......|.:  |..|:|           .|||.|:
  Rat   552 GLENYGRAQSA--APAKTTDGLYTYWSATGET-----------QPPQSSN 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	15/72 (21%)
		BBOX	321..360	CDD:237988	8/38 (21%)
		BBC	369..494	CDD:128778	26/152 (17%)
		NHL_brat_like	913..1186	CDD:271329
		NHL repeat	936..972	CDD:271329
		NHL repeat	983..1025	CDD:271329
		NHL repeat	1028..1064	CDD:271329
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
Trim42	NP_001013977.1	RING-HC_TRIM42_C-III	143..193	CDD:319492	16/87 (18%)
		Bbox_SF	235..280	CDD:412124	14/46 (30%)
		Bbox_SF	287..326	CDD:412124	13/68 (19%)
		Topo_C_assoc	<341..432	CDD:421254	14/97 (14%)
		FN3	612..698	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR25462
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010