DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-P26 and Trim45

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001099923.1	Gene:	Trim45 / 295323	RGDID:	1309168	Length:	579	Species:	Rattus norvegicus

Alignment Length:	431	Identity:	116/431 - (26%)
Similarity:	197/431 - (45%)	Gaps:	50/431 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 LDSLED-SCSGLMIKDGDKLCKLCSLRLVMPRILSCLHVFCEDCLQ-----AVV-----SKDTMS 195
            ::.|:| |.||   ..|...|..|.....:||:|.|||..|..||:     :||     ..||.|
  Rat    12 VNKLQDASASG---SSGKTHCPSCLRLFKVPRLLPCLHTVCTSCLERLDPFSVVDIRGGDSDTSS 73

  Fly   196 ASS----PNSCSSSSFDGSEHQNRLSAVFIECPVCKQETPLGPKGIKALPCDYIVTNILDLSNL- 255
            ..|    |.|||.....|           |.||||..:..|...|:|||..|::..|.:.|.:|
  Rat    74 EGSIFQEPKSCSLKPQIG-----------ILCPVCDAQVDLPLGGVKALTVDHLAMNDVMLESLH 127

  Fly   256 -ESEHIVCTSCKSKEEAISRCNDCANFLCNGCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHK 319
             |.:.:||..| |..|...||..|...||:.|..||:..:...:|.:|.::||.....    :.|
  Rat   128 GEGQGLVCDLC-SDREVEKRCQTCKANLCHFCCQAHRRQKKTTDHTMVDLKDLKGYSR----VGK 187

  Fly   320 PVFCPQHVSENLKYYCFTCQVPTCNDCLLSDHKGSDHHYE-TATVAEQ---AVRADLEETLSDTL 380
            |:.||.|.:|.|:.:|..|..|.|.||::.:|:  :|.|: |:.|..:   :||    |.|.||.
  Rat   188 PILCPSHPAEELRLFCELCDRPVCRDCVVGEHR--EHPYDFTSNVIHKHGDSVR----ELLRDTQ 246

  Fly   381 KKADYCNDAGSNLGSALTELQSQHDTVRQQIEDAYKCYKRMLESIKDQMLNELGRLHSDRELKIM 445
            ...:...||.:.:.|:...||.:.:.|...:....:.|.|.:|..:|::|.:|..:...:|..:.
  Rat   247 PHVEALEDALAQIKSSNNALQERVEAVAADVRTFSEGYIRAIEEHRDKLLRQLDDIRVQKENSLQ 311

  Fly   446 DLMQSMENTMGKLQHAAQFGQRAVDKANSIEFLLLKPIISAQC--LNLMEQTPKCDINYQLQFDS 508
            .....:|..:..::...:|.:..:...:.:|.|:.|.::..:.  ||.:|.:.:..:|:::.| |
  Rat   312 LQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILVTKGVVVERLRKLNKVEYSARPGVNHKICF-S 375

  Fly   509 KPEMFEQFAREMFGKFQTDHIDSSPKKLGMTQQLQQQQQQQ 549
            ..|.......|::|...|..:|.:...| ..:.|.:.:::|
  Rat   376 PQEKARCQGYEVYGAINTQEVDPAQCVL-QGEDLHRAREKQ 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	27/85 (32%)
		BBOX	321..360	CDD:237988	14/39 (36%)
		BBC	369..494	CDD:128778	25/126 (20%)
		NHL_brat_like	913..1186	CDD:271329
		NHL repeat	936..972	CDD:271329
		NHL repeat	983..1025	CDD:271329
		NHL repeat	1028..1064	CDD:271329
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
Trim45	NP_001099923.1	BBOX	189..226	CDD:237988	14/38 (37%)
		iSH2_PI3K_IA_R	237..357	CDD:304922	24/123 (20%)
		Filamin	396..492	CDD:279024	4/21 (19%)
		IG_FLMN	398..496	CDD:214720	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR25462
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020