DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and TRIM2

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001362417.1	Gene:	TRIM2 / 23321	HGNCID:	15974	Length:	802	Species:	Homo sapiens

Alignment Length:	1084	Identity:	205/1084 - (18%)
Similarity:	357/1084 - (32%)	Gaps:	387/1084 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 MIKDGDK---LCKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQN 214
            :::..||   :|.:|..|...|::|.|||.|||.|||..:...:::.|
Human    39 VVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLS----------------- 86

  Fly   215 RLSAVFIECPVCKQETPLGPKGIKALPCDYIVTNILDL------SNLESEHIVCTSCKSKEEAIS 273
                    ||||:|.:.|..||:.||..::.:||::|:      ||.|...|:.|     ..|::
Human    87 --------CPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNAEESSILET-----VTAVA 138

  Fly   274 RCNDCANFLCNGCDNAHKYMRCFENHHVVR-----IEDLTKNVHDKLIIHKPVFCPQHV--SENL 331
                           |.|.:.| .||...|     :..|..|...::|:  |.: |..|  .:.:
Human   139 ---------------AGKPLSC-PNHDGNRQSFAVVPRLVSNPWPQVIL--PPW-PSKVLGLQVM 184

  Fly   332 KYYCFTCQVPTCNDCLLSDHKGSDH-HYETATVAEQAVRADLEETLSDTLKKADYCNDAGSNLGS 395
            ::||.:|:...|.:|...:|  ::| ......|.||. :|.|:..|....|:....:.|...:..
Human   185 EFYCQSCETAMCRECTEGEH--AEHPTVPLKDVVEQH-KASLQVQLDAVNKRLPEIDSALQFISE 246

  Fly   396 ALTELQSQHDTVRQQIEDAYKCYKRMLESIKDQMLNEL----GRLHSDRELKIMDLMQSMENTMG 456
            .:.:|.:|..::...|...:...::.|...|..:|.||    |..|...:.::..|:|..|:
Human   247 IIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLQGQES--- 308

  Fly   457 KLQHAAQFGQRAVDKANSIEFLLLKPIISAQCLNLMEQTPKCDINYQLQFDSKPEMFEQFAREMF 521
             ::..:.|..:|::.....|.||:|..:|.:...|.:|          .|...|.
Human   309 -IKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQ----------DFPLHPR---------- 352

  Fly   522 GKFQTDHIDSSPKKLGMTQQLQQQQQQQQQLQQQQHQHQHQVQQQQHHHQQQQQQKQQVQHQQQQ 586
               :.|.:|...:..|:.:.:
Human   353 ---ENDQLDFIVETEGLKKSI-------------------------------------------- 370

  Fly   587 QKLQLQQQQQHQHNSNNLIVGHRGSSSVQGRLTSAVFSPISLPSSLQSSFDGDTNSVMSNFSMMD 651
                        ||...::.                                 ||:|.|
Human   371 ------------HNLGTILT---------------------------------TNAVAS------ 384

  Fly   652 SPPQPSSQQQLPSAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQQHQVQQQQQQQVLHQPTSAQSM 716
                                                      :.....:..:|.::.||
Human   385 ------------------------------------------ETVATGEGLRQTIIGQP------ 401

  Fly   717 PQQLGQLVAPQGIVQQAGHVNLNAGPGPNISINGLGAGGPPPSFSMLEYNISRLASLTETMPDTL 781
                                                                  .|:|.|..|..
Human   402 ------------------------------------------------------MSVTITTKDKD 412

  Fly   782 NDALAVGGGAAGPVPNVVAQVPGGSAVTGAAVVGASHAHQQQSQAVMPASAVTPTQPITLADILS 846
            .:....|                                    .|.:.|...||...:...:||.
Human   413 GELCKTG------------------------------------NAYLTAELSTPDGSVADGEILD 441

  Fly   847 GDQRALNNLQALAKLGLNNNDFCM-----------PPATSPSLQS--LNPIVGGVEDMGLNNFHA 898
            ........|..:.|.|    ||.:           .|.....::|  ::|...||:       ..
Human   442 NKNGTYEFLYTVQKEG----DFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGVK-------RR 495

  Fly   899 VAAPGTTSV------------VTGRNKATPMQ--IRCKFGSLGTAKGQFNSPHGFCLGVDEEIIV 949
            |.:||:..|            .||:.|..|::  :..:.|:.|..||:|.:..|.....:.:|::
Human   496 VKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTNLQGVAASTNGKILI 560

  Fly   950 ADTNNHRIEVFDKMGALKFQFGVAGKEEGQLWYPRKVAVMHNNGKFVVCDRGNERSRMQIFSKCG 1014
            ||:||..:::|...|..|.:||:.|:..|||..|..||| |.:|..::.|..|:  .:.|||..|
Human   561 ADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAV-HPSGDIIIADYDNK--WVSIFSSDG 622

  Fly  1015 HFMRKIAIRYIDIVAGLAVTAKGHIVAVDSVSPTVFVISEEGELVRWF----DCSDYMREPSDIA 1075
            .|..||....:....|::|...|||:.||:.:..||:....|::|..|    :.......|...|
Human   623 KFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAA 687

  Fly  1076 IR-DNDFYVCDFKGHCVAVFQDDGTFLYRI-----GNEKVTCFPNGIDISNAGDVLIGDSHGNRF 1134
            :. :|:..:.||..|.|.||..:|.|:.:.     ||.:... |.|:.:.:.|::::.|...:|.
Human   688 VNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNA-PTGVAVDSNGNIIVADWGNSRI 751

  Fly  1135 HVACYSREGALQSEFECPHVKVSRCCGLKITSEGYVVTLAKNNH 1178
            .|  :...|:..|........:....||.:||:|:||.....||
Human   752 QV--FDGSGSFLSYINTSADPLYGPQGLALTSDGHVVVADSGNH 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	22/74 (30%)
		BBOX	321..360	CDD:237988	9/41 (22%)
		BBC	369..494	CDD:128778	26/128 (20%)
		NHL_brat_like	913..1186	CDD:271329	79/278 (28%)
		NHL repeat	936..972	CDD:271329	10/35 (29%)
		NHL repeat	983..1025	CDD:271329	15/41 (37%)
		NHL repeat	1028..1064	CDD:271329	12/39 (31%)
		NHL repeat	1068..1107	CDD:271329	12/44 (27%)
		NHL repeat	1112..1151	CDD:271329	8/38 (21%)
		NHL repeat	1157..1183	CDD:271329	9/22 (41%)
TRIM2	NP_001362417.1	RAD18	33..>136	CDD:227719	35/126 (28%)
		RING-HC_TRIM2	47..92	CDD:319681	19/69 (28%)
		Bbox_SF	142..214	CDD:381767	17/77 (22%)
		BBC	219..345	CDD:128778	26/130 (20%)
		IG_FLMN	383..479	CDD:214720	21/243 (9%)
		NHL_TRIM2_like	529..802	CDD:271330	77/271 (28%)
		NHL repeat	547..586	CDD:271330	11/38 (29%)
		NHL repeat	594..633	CDD:271330	15/41 (37%)
		NHL repeat	636..672	CDD:271330	12/35 (34%)
		NHL repeat	680..720	CDD:271330	11/39 (28%)
		NHL repeat	729..769	CDD:271330	8/42 (19%)
		NHL repeat	772..798	CDD:271330	9/22 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.880