DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-P26 and Nhlrc3

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_766089.1	Gene:	Nhlrc3 / 212114	MGIID:	2444520	Length:	347	Species:	Mus musculus

Alignment Length:	291	Identity:	70/291 - (24%)
Similarity:	98/291 - (33%)	Gaps:	103/291 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   797 NVVAQVPGGSAVTGAAVVGASHAHQQQSQAVMPASAVTP-TQPITLADILSGDQ----RALNNLQ 856
            |.....|.|..|:|                       || .|.:.:.|:.||..    :..|:|.
Mouse   101 NYTVDTPHGMFVSG-----------------------TPFEQSVWITDVGSGPYGHTVKKYNSLG 142

  Fly   857 ALAKL---------GLNNNDFCMPPATSPSLQSLNP------------IVGGVEDMGLNNFHAVA 900
            .|.::         |||            .||..||            ||.|  |.||||
Mouse   143 DLVQVLGTPGKKGTGLN------------PLQFDNPAELYVDDTGEMYIVDG--DGGLNN----- 188

  Fly   901 APGTTSVVTGRNKATPMQIRCKFGSLGTAKGQFNSPHGFCLGVDEEIIVADTNNHRIEVFDK--- 962
                 .:|........:.:|   |..||...:||.||...|.....:.|||..|.|::||||
Mouse   189 -----RLVKLSQDFMILWLR---GENGTGPAKFNIPHSVTLDAVGRVWVADRGNKRLQVFDKDTG 245

  Fly   963 --MGALKFQFGVAGKEEGQLWYPRKVAVMHNNGKFVVCDRGNERSRMQIF-----SKCGHFMRKI 1020
              :||....|    .|||    |..|. ...:||:::..:.| .||:.:.     ...|......
Mouse   246 EWLGAWDNCF----TEEG----PSAVR-FTPDGKYLIVAQLN-LSRLSVLLAPPSGSIGDCSVVS 300

  Fly  1021 AIRYIDIVAGLAVTAKGHIVAVDSVSPTVFV 1051
            .|:..|.|.       .|::.||..:..|:|
Mouse   301 TIQLADQVL-------PHLLEVDRKTGAVYV 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325
		BBOX	321..360	CDD:237988
		BBC	369..494	CDD:128778
		NHL_brat_like	913..1186	CDD:271329	40/149 (27%)
		NHL repeat	936..972	CDD:271329	15/40 (38%)
		NHL repeat	983..1025	CDD:271329	9/46 (20%)
		NHL repeat	1028..1064	CDD:271329	6/24 (25%)
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
Nhlrc3	NP_766089.1	NHL 1	47..93
		NHL	66..336	CDD:302697	70/291 (24%)
		YncE	<66..308	CDD:225926	64/266 (24%)
		NHL repeat	107..153	CDD:271320	13/68 (19%)
		NHL 2	150..196		16/69 (23%)
		NHL repeat	166..205	CDD:271320	11/53 (21%)
		NHL 3	200..243		17/45 (38%)
		NHL repeat	213..250	CDD:271320	14/36 (39%)
		NHL repeat	258..299	CDD:271320	10/46 (22%)
		NHL 4	294..338		9/38 (24%)
		NHL repeat	308..335	CDD:271320	6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010