DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and nhl-1

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_499028.1	Gene:	nhl-1 / 176295	WormBaseID:	WBGene00003597	Length:	974	Species:	Caenorhabditis elegans

Alignment Length:	1120	Identity:	226/1120 - (20%)
Similarity:	390/1120 - (34%)	Gaps:	287/1120 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 CKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQNRLSAVFIECPV 225
            |.:|..|...|::|.|.|.||..||:              ||:.:.     |:|      ::||.
Worm    43 CPICLDRYKQPKLLPCQHTFCYPCLE--------------SCADTL-----HRN------LKCPE 82

  Fly   226 CKQETPLGPKGIKALPCDYIVTNILDLSNLESEHIVCT--SCKSKEEAISRCNDCANFLCNGCDN 288
            |:.|..:...|:||...:|.:|..|::      |:..|  |....||.|.|.|
Worm    83 CRAEHNIPYDGVKAFQPNYTLTGFLEI------HLQATPESAAEIEEYIHRYN------------ 129

  Fly   289 AHKYMRCFENHHVVRIEDLTKNVHDKLIIHKPVFCPQHVSENLKYYCFTCQVPTCNDCLLSDHKG 353
               ..||              .:.|:....:|              |..|....|.:|
Worm   130 ---LERC--------------KICDEKADCEP--------------CAHCDRKACKEC------- 156

  Fly   354 SDHHYETATVAEQAVRADLEETLSDTLKKADYCNDAGSNLGSALTELQSQHDTVRQQIEDAYKCY 418
            ...|.:       .::.|:...|:...:.|:...:|..||...:..:....:|.:.:|::.:..|
Worm   157 RQTHMD-------MLKRDMSRLLNQVKRLANRITEASDNLSKGVDMMTMNCETTKAEIKEYFHRY 214

  Fly   419 KRMLESIKDQMLNELGRLHSDRELKIMDLMQSMENTMGKLQHAAQFGQRAVDKANSI---EFLLL 480
            :|.|:..:|..|.|:....:.....:.:|...:|.....:..|......|:....||   |.:.:
Worm   215 QRDLKKKEDNFLMEVDTFQATETRNMSNLRDVLEIESSNMSEAVSRLDAAIKGECSIEDSELVRM 279

  Fly   481 KPIISAQCLNLMEQTPKCD--INYQLQFDSKPE----------------MFEQFAREMFGKFQTD 527
            |...:.....|....|..|  .|.:|:|.:..:                :..||:    |::...
Worm   280 KNTFTEGLEYLRNFQPDADELFNRKLRFSAGDDAAKLPAAITTSGELCVLVPQFS----GRYLPL 340

  Fly   528 HIDSSPKKLGMTQQLQQQQQQQQQLQQQQHQHQHQVQQQQHHHQQQQQQKQQVQHQQQQQKLQLQ 592
            .....|:...:..:....:.:..:....:.:...:. ..:|.|:..:..:..::::::|   ||:
Worm   341 EQSYLPRPFRLPLESDSYRVKSDERASMRDREADRT-SSRHSHRNPEPDESSIRYRRRQ---QLE 401

  Fly   593 QQQQHQ-HNSN---NLIV-------GHRGSSSVQGRLTSAVFSPISLPSSLQSSFDGDTNSVMSN 646
            .:..:: .||:   :|:.       ..|.|.....|:|.:|....|.|:||... :.:|...:|.
Worm   402 DEAWNRLRNSSAAPSLLTTSVTADSSSRTSPWAADRVTRSVEPTKSRPTSLIVP-NTETPRTVSP 465

  Fly   647 FSMMDSPPQ------------PSSQQQL-----PSAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQ 694
            .|....|||            |:...||     |..:|||.......::.:.:       ::.||
Worm   466 ASKPPLPPQSVERVERTEDASPAPLPQLPIRKPPLPRQQSSNDDSLNEKVETI-------RRAHQ 523

  Fly   695 QHQ-VQQQQQQQVLHQPTSAQSMP--QQLGQLVAPQGIVQQAGHVNLNAG-----PGPNISINGL 751
            |.| ..:...:.|..:.:..:..|  ...|::    .||.:|..||.:.|     ||....||
Worm   524 QRQDASRAASRAVSSEESEGEDFPVSTNRGRI----RIVCRAASVNRDDGLMSMIPGTGTIIN-- 582

  Fly   752 GAGGPPPSFSMLEYNISRLASLTETMPDTLNDALAVGGGAAGPVPNVVAQVPGGSAVTGAAVVGA 816
               .|||...:                           .|:.|:.|       |::...|..|..
Worm   583 ---VPPPQHQL---------------------------PASAPITN-------GTSEQVAIPVTH 610

  Fly   817 SHAHQQQSQAVMPASAVTPTQPITLADILSGDQRALNNLQALAKLGLNNNDFCMPPATSPSLQSL 881
            ....:.:|..|:||......|..         ||:..|....|:.            ||..:|.|
Worm   611 FTGEEDESDIVVPAWLQRRRQRF---------QRSRTNPDIQAQF------------TSARVQQL 654

  Fly   882 NPIVGGVEDMGLNNFHAVAAPGTT--------SVVTGRNKATPMQI---------RCKFGSLGTA 929
                       |....:.....||        :|:..|.::...:.         |..||..|..
Worm   655 -----------LAERQSRLDSSTTTDEEKEKLAVLRQRGRSASREAGEWRARGRPRAVFGRKGAK 708

  Fly   930 KGQFNSPHGFCLGVDEEIIVADTNNHRIEVFDKMGALKFQFGVAGKEEGQLWYPRKVAVMHNNGK 994
            .|:.|.|.|.|......:...|::|||:.||||.|....|||..|...|||  .....:..:..:
Worm   709 DGELNWPRGICALSGGLVATCDSSNHRVCVFDKDGKFVRQFGGYGAGAGQL--DSAAGLASSKLR 771

  Fly   995 FVVCDRGNERSRM------QIFSKCGHFMRKIAIRYIDIVAGLAVTAKGHIVAVDSVSPTVFVIS 1053
            .:|.||.|.|..:      .:||..||......   .:...|:||...|.|...|..:..|.|..
Worm   772 VIVSDRYNHRISVFGLEGDHLFSFGGHGQGNAK---FNNPWGVAVDDLGSIYVADKDNHRVQVFD 833

  Fly  1054 EEGELVRWFDCSDY----MREPSDIAIR--DNDFYVCDFKGHCVAVFQDDGTFLYRIGNE----- 1107
            :.|:.:..|....:    :..|..||:.  .:..||.|...|.::||...|..|:..|.|
Worm   834 KNGQFIAKFGSFGHLPGQLNSPLFIAVSRVTHHVYVSDSSNHRISVFDPHGVHLFSFGEEGFHGG 898

  Fly  1108 --KVTCFPNGIDISNAGDVLIGDSHGNRFHVACYSREGALQSEFECPHVKVSRCCGLK---ITSE 1167
              |   ||.||.|.:..:::|.||..||..|  :..:|...|.|........:..|::   :|::
Worm   899 QFK---FPRGIAIDSQENLIIADSGNNRIQV--FDAQGQFVSSFGTWGGGAGQLKGVEDVCVTAD 958

  Fly  1168 GYVVTLAKNNHHVLV 1182
            |.:|...:.||.:.:
Worm   959 GSIVVTDRENHRIQI 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	18/68 (26%)
		BBOX	321..360	CDD:237988	5/38 (13%)
		BBC	369..494	CDD:128778	23/127 (18%)
		NHL_brat_like	913..1186	CDD:271329	78/301 (26%)
		NHL repeat	936..972	CDD:271329	14/35 (40%)
		NHL repeat	983..1025	CDD:271329	9/47 (19%)
		NHL repeat	1028..1064	CDD:271329	10/35 (29%)
		NHL repeat	1068..1107	CDD:271329	12/40 (30%)
		NHL repeat	1112..1151	CDD:271329	14/38 (37%)
		NHL repeat	1157..1183	CDD:271329	6/29 (21%)
nhl-1	NP_499028.1	zf-C3HC4	43..83	CDD:278524	17/64 (27%)
		FRQ	<426..545	CDD:286504	27/126 (21%)
		NHL_TRIM71_like	691..974	CDD:271324	78/293 (27%)
		NHL repeat	715..754	CDD:271324	15/38 (39%)
		YncE	721..>973	CDD:225926	69/261 (26%)
		NHL repeat	762..800	CDD:271324	9/37 (24%)
		NHL repeat	808..844	CDD:271324	10/35 (29%)
		NHL repeat	852..893	CDD:271324	12/40 (30%)
		NHL repeat	902..932	CDD:271324	11/31 (35%)
		NHL repeat	948..974	CDD:271324	6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920