DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and ncl-1

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001299853.1	Gene:	ncl-1 / 176084	WormBaseID:	WBGene00003559	Length:	982	Species:	Caenorhabditis elegans

Alignment Length:	1306	Identity:	261/1306 - (19%)
Similarity:	450/1306 - (34%)	Gaps:	494/1306 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 DVTSSSSIGSETSISSTGSTAIAGPSTLLDDSNSSGLGLVVDVDSNGSSQELSSHGVTELDSLED 147
            :::.|.|:|..::.::.||          |:...|.:     ..:.|....||:.|....:|...
Worm    12 EMSESESLGGSSASTTAGS----------DEYTMSQI-----FGAAGRPIPLSTFGTAIPNSWGS 61

  Fly   148 SCSGLMIKDGDKL-------------CKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSP 199
            :.|..|:.....|             |.||......|::|:|.|.||:.||
Worm    62 AVSQPMLAGSFGLAPTPPPVIQEIVKCTLCLEPYRDPKVLACFHSFCKGCL-------------- 112

  Fly   200 NSCSSSSFDGSEHQNRLSAVFIECPVCKQETPLGPK-GIKALPCDYIVTNILD------------ 251
                      ::|..:...:.  ||.|..||.|..: |:.:|..|:.:.::::
Worm   113 ----------AKHLEQPERII--CPQCHMETQLSVQLGLDSLLTDFGLESVMNKQQQLFANMGLS 165

  Fly   252 -------------------------------------------------LSNL----ESEH---- 259
                                                             |||.    :.:|
Worm   166 DIGAPTPSTAIPVPNAHLHPSMVAGSDPSNPVVGFGFGSPSSTTSSSPPLSNSPTIEQQQHAQLT 230

  Fly   260 ---------------------------IVCTSCKSKE---EAISRCNDCANFLCNGCDNAHKYMR 294
                                       :.|:.|||.|   :|.|.|.||...||:.|..|||:|.
Worm   231 AMMQGIMSNNNVAVSNGSGVQVASVPAVHCSGCKSNETKLQATSFCQDCNANLCDNCTMAHKFMH 295

  Fly   295 CFENHHVVRIEDLT------------------------------KNVHDKLII---HKPVFCPQH 326
            ||.:|.||   .||                              |...|.:::   .:.|.|.||
Worm   296 CFADHRVV---SLTTPGTGSSSSSTSSSSSASSTSSHQVPSLGGKQSPDSMMLGSGKRSVLCLQH 357

  Fly   327 VSENLKYYCFTCQVPTCNDCLLSDHKGSDHHYE-TATVAEQAVRADLEETLSDTLKKADYCNDAG 390
            .:..|.::|.:|.:..|.||.:|||....|.|| .|.||::.: ..:|:.::|...|.....|..
Worm   358 RASELVFFCVSCNLAICRDCTVSDHPSGTHQYELIADVADKQM-LKMEQLIADARSKHADMLDMF 421

  Fly   391 SNLGSALTELQSQHDTVRQQIEDAYKCYKRMLESIKDQMLNELGRLHSDRELKIMDLMQSMENTM 455
            ..:.:....|.:.......|:|:.......:::..|..:..::....:.:::::..:.:.:::..
Worm   422 KQVDNKQQVLTASLHNAHAQLEETVSNLINVIQDQKKTLAKDIDNAFAAKQIQLTMVDKRIQSMA 486

  Fly   456 GKLQHAAQFGQRAVDKANSIEFLLLKPIISAQCLNLMEQTPKCDINYQLQFDSKPEMFEQFAREM 520
            .||....:|.:|.:..|:..|.::.|.::                      |::.::|..|..:.
Worm   487 DKLSQTIEFSRRLMSFASPAEVMVFKQLL----------------------DTRLQLFLGFNPDT 529

  Fly   521 FGKFQT----DHIDSSPKKLGMTQQLQQQQQQQQQLQQQQHQHQHQVQQQQHHHQQQQQQKQQVQ 581
            .|...|    :::.::    |:
Worm   530 SGVLMTPCEIEYLGAA----GL------------------------------------------- 547

  Fly   582 HQQQQQKLQLQQQQQHQHNSNNLIVGHRGSSSVQGRLTSAVF--SPISLPSSLQSSFDGDTNSVM 644
                               .||       |:|...:|..:|.  |||:             |:..
Worm   548 -------------------FNN-------SASTVSQLLGSVHGGSPIN-------------NAPA 573

  Fly   645 SNFSMMDSPPQPSSQQQLPSAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQQHQVQQQQQQQVLHQ 709
            :|..:|   ||..   ..|..:.||:             :..::|.|
Worm   574 ANDFLM---PQAG---LAPIGRAQSR-------------IIPIEQNQ------------------ 601

  Fly   710 PTSAQSMPQQLGQLVAPQGIVQQAGHVNLNAGPGPNISINGLGAGGPPPSFSMLEYNISRLASLT 774
              .|:|.|..:            ||.:.:||....|:.......||...|.
Worm   602 --LARSPPHHI------------AGSLPMNAYSDSNLLRPNKDFGGSSQSL-------------- 638

  Fly   775 ETMPDTLNDALAVGGGAAGPVPNVVAQVPGGSAVTGAAVVGASHAHQQQSQAVMPASAVTPTQPI 839
                              ||..      |.|::|.|||....|..:.:.|..|.|
Worm   639 ------------------GPFN------PLGASVPGAAADPFSSQYDKWSLGVEP---------- 669

  Fly   840 TLADILSGDQRALNNLQALAKLGLNNNDFCMPPATSPSLQSLNPIVGGVEDMGLNNFHAVAAPGT 904
            ::..:|.|                                      |.|::   ..|..:..|..
Worm   670 SVGGLLEG--------------------------------------GNVDE---EKFQTLFPPSR 693

  Fly   905 TSVVTGRNKATPMQIRCKFGSLGTAKGQFNSPHGFCLGVDEEIIVADTNNHRIEVFDKMGALKFQ 969
            :.:     |...|...||||..|..:|||..|.|..:....:|:|||||||||:||||.|..|||
Worm   694 SQI-----KRQKMIYHCKFGEFGVMEGQFTEPSGVAVNGQGDIVVADTNNHRIQVFDKEGRFKFQ 753

  Fly   970 FGVAGKEEGQLWYPRKVAVMHNNGKFVVCDRGNERSRMQIFSKCGHFMRKIAIRYIDIVAGLAVT 1034
            ||..||.:|||.||.:|||....|.|||.:| :...::|::::.|.|:||.....:....|:.|.
Worm   754 FGECGKRDGQLLYPNRVAVNRTTGDFVVTER-SPTHQIQVYNQYGQFLRKFGANILQHPRGVCVD 817

  Fly  1035 AKGHIVAVDSVSPTVFVISEEGELVRWFDCSDYMREPSDIAIRD-NDFYVCDFKGHCVAVFQDDG 1098
            :||.|:.|:.....|.:....|.:::.|.||.|:..|:.:...| |:..:.|.:.||:.||..:|
Worm   818 SKGRIIVVECKVMRVIIFDMFGNILQKFSCSRYLEFPNGVCTNDKNEILISDNRAHCIKVFSYEG 882

  Fly  1099 TFLYRIGNEKVTCFPNGIDISNAGDVLIGDSHGNRFHVACYSREGALQSEFECPHVKVSRCCGLK 1163
            .:|.:||.|.||.:|.|:.|::.|:|::.|:| |.|::..:|::|.:....| ..||.::|..:.
Worm   883 QYLRQIGGEGVTNYPIGVGINSLGEVVVADNH-NNFNLTVFSQDGTMIGALE-SRVKHAQCFDVA 945

  Fly  1164 ITSEGYVVTLAKNNHHVLVLNTLYVHXLQIKARNNRPSVDMNKYNYKY---SSGKIYGCRRQQQS 1225
            :..:|.||..:|                           |...|.|::   :||         ||
Worm   946 LVDDGSVVLASK---------------------------DYRLYLYRFLPATSG---------QS 974

  Fly  1226 TNTSNS 1231
            |::::|
Worm   975 TSSASS 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	16/84 (19%)
		BBOX	321..360	CDD:237988	16/39 (41%)
		BBC	369..494	CDD:128778	15/124 (12%)
		NHL_brat_like	913..1186	CDD:271329	98/273 (36%)
		NHL repeat	936..972	CDD:271329	21/35 (60%)
		NHL repeat	983..1025	CDD:271329	14/41 (34%)
		NHL repeat	1028..1064	CDD:271329	9/35 (26%)
		NHL repeat	1068..1107	CDD:271329	12/39 (31%)
		NHL repeat	1112..1151	CDD:271329	11/38 (29%)
		NHL repeat	1157..1183	CDD:271329	5/25 (20%)
ncl-1	NP_001299853.1	RING	87..131	CDD:238093	15/69 (22%)
		BBOX	256..305	CDD:197662	22/51 (43%)
		BBOX	349..392	CDD:197662	16/42 (38%)
		BBC	399..525	CDD:128778	17/148 (11%)
		NHL_brat_like	697..967	CDD:271329	101/299 (34%)
		NHL repeat	720..756	CDD:271329	21/35 (60%)
		NHL repeat	767..808	CDD:271329	14/41 (34%)
		NHL repeat	811..847	CDD:271329	9/35 (26%)
		NHL repeat	851..891	CDD:271329	12/39 (31%)
		NHL repeat	896..934	CDD:271329	12/39 (31%)
		NHL repeat	939..964	CDD:271329	7/51 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I8279
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920