DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and nhl-2

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_498026.1	Gene:	nhl-2 / 175654	WormBaseID:	WBGene00003598	Length:	1032	Species:	Caenorhabditis elegans

Alignment Length:	1221	Identity:	291/1221 - (23%)
Similarity:	479/1221 - (39%)	Gaps:	300/1221 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 TSSSSSSSSSSSSSSGSCSGSGTDTDTGKGSSNVGSLDVTSSSSIGSETSISSTGSTAIAGPSTL 110
            ||:.:....|.::|:.:...|||                   .|:..:..:.||.|:.:.|...|
Worm     9 TSAVNGRHESPATSTNNTQNSGT-------------------PSLNGQDPLRSTSSSPLFGTEPL 54

  Fly   111 LDDSNSSGLGLVVDVDSNGSSQELSSHGVTELDSLEDSCSGLMIKDGDKLCKLCSLRLVMPRILS 175
            .:|.::|                                           |..|......||:|.
Worm    55 PEDDHAS-------------------------------------------CPYCQQDFRKPRVLD 76

  Fly   176 CLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQNRLSAVF-------------------I 221
            |||..||||:.|.:.....:.|:          ..|.:.|.:|..                   |
Worm    77 CLHSMCEDCIIAQLDGHLQAKSA----------AIEEKKRATAAMLDCELETPKVKERPTPPGVI 131

  Fly   222 ECPVCKQETPLG--PKGIKALPCDYIVTNILDLSNLESEHIV------CTSCKSKEEAISRCNDC 278
            .||:|.||:.:|  .:.:.|:..|::  .:.::..:|.|.:|      ||:|||::|||:.|:.|
Worm   132 RCPICSQESHVGNDVRYVHAMLLDFV--RLAEMKEVEVEKMVAHHRKPCTACKSEQEAIAFCDQC 194

  Fly   279 ANFLCNGCDNAHKYMRCFENHHVVRIEDLTK-NVHDKLIIHKPVFCPQHVSENLKYYCFTCQVPT 342
            ::.||..|..||..|..|:.|.|....||.: ..|.:|   :.|.|..| :::::|.|..|:...
Worm   195 SSDLCENCTTAHTVMNLFQGHTVTTFADLRQPGAHPEL---RQVMCSTH-NQHMRYLCAACETAA 255

  Fly   343 CNDCLLSDHKGSDHHYETATVAE---QAVRADLEETLSDTLKKADYCNDAG--SNLGSALTELQS 402
            |..||..||.    :::...:.|   .|:|.|:..|:....||  |.|...  ::|.....:|..
Worm   256 CKQCLEVDHL----NHKIIDINELVINAIREDVTSTVDRVEKK--YNNSVADMNSLPDKSQQLNE 314

  Fly   403 QHDTVRQQIEDAYKCYKRMLESIKDQMLNELGRLHSDRELKIMDLMQSMENTMGKLQHAAQFGQR 467
            |::..:.:::..|:..:..:|....:.:|:|......:|..|.::.:..:....::..|..|.:|
Worm   315 QYEIAKYRVDKHYEELRNSIEEAYQKSVNDLEEARIRQESNIDEMYRKSQVNEARVHDAINFTRR 379

  Fly   468 AVDKANSIEFLLLKPIISAQCLNLMEQTPKCDINYQLQF--DSKPEMFEQFAREMFGKFQTDHID 530
            .:.|.|.:|.::.:..:..|..||....|......:|:|  .||.:: :.|..::.|......|.
Worm   380 LLTKGNGLELVVSRKKVIQQFGNLSHAIPSHGHQVELEFYTPSKKQI-DHFVHQLTGTVIGRVIQ 443

  Fly   531 SSPKKLGMTQQLQQQQQQQQQLQQQQHQHQHQVQQQQHHHQQQQQQKQQVQHQQQQQKLQLQQQQ 595
            .:.|.:|........:.::...|....:     .....:..||.:..:.|..|..|......:::
Worm   444 PTVKDVGNATAASTDRSERGGSQPGGGR-----SSSAANPSQQDEWGRPVYSQNPQLGAIGGERK 503

  Fly   596 QHQHNSNNLIVGHRGSSSVQGRLTSAVFSPISLPSSLQSSFDGDTNSVMSNFSMMDSPPQPSSQQ 660
            ::..|..|   |.||.|:..|.     :.|.|.|....:                 .||....|.
Worm   504 KNTQNGTN---GTRGDSNAFGG-----WPPSSHPPESTT-----------------PPPVTGPQT 543

  Fly   661 QLPSAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQQHQVQQQQQQQVLHQPTSAQSMPQQLGQLVA 725
            .:..|                                            ||          |..|
Worm   544 MITGA--------------------------------------------PT----------QTAA 554

  Fly   726 PQGIVQQAGHVNLNAGPGPNISINGLGAGGPPPSFSMLEYNISRLASLTETMPDTLNDALAVGGG 790
            |  ||.|....||     ||.:.....|.|..|....|..|...||:||....:          |
Worm   555 P--IVSQQQLSNL-----PNAAAMAAAAAGMRPDLVALAANHMDLAALTNGSTN----------G 602

  Fly   791 AAGPVPNVVAQV-----PGGSAVTGAAVVG----ASHAHQQQSQAVMPASAVTPTQPITLADILS 846
            :..|:|..:...     .|..||......|    ||.|:.||..|.....|:...:       |:
Worm   603 SQTPLPESIFPAMWNARQGLPAVATPTTTGLSTNASAAYMQQKLAAAQLQALASHR-------LN 660

  Fly   847 GDQRALNNLQ------------ALAKLGLNNNDFCMPPATSPSLQSLNPIVGGVEDMGLNNFHAV 899
            ....::|||:            |:..|.||      |..||.:..:|                |.
Worm   661 PQIMSMNNLRTNQTIQEFLAMNAMGNLSLN------PQLTSAAAAAL----------------AA 703

  Fly   900 AAPGTTSVVT-------GRNKA-----TPMQIRCKFGS--LGTAKGQFNSPHGFCLGVDEEIIVA 950
            .|...::|.|       .:|.|     :.:::...||:  .|:...:.:.|.||||...::|::|
Worm   704 TAAANSAVTTTASDVGQSQNSANAQRVSDLKVHSVFGTSQQGSTIRELHCPSGFCLSDTDDILIA 768

  Fly   951 DTNNHRIEVFDKMGALKFQFGVAGKEEGQLWYPRKVAVMHNNG-KFVVCDRGNE-RSRMQIFSKC 1013
            ||||||:.|.......|  .|..|.::|||.:||||..:.... ::||.|:|.: ::|.|||...
Worm   769 DTNNHRVVVCGPPHPWK--IGRPGTDDGQLCFPRKVIALRGEAVRYVVLDKGGDGKTRAQIFEAR 831

  Fly  1014 GHFMRKIAIRYIDIVAGL-----AVTAKGHIVAVDSVSPTVFVISEEGELVR---WFDCSDYMRE 1070
            |.|::::.:..:....|:     |.|..|.::.||:..   ||.|.:.:..|   |||.|..:.|
Worm   832 GEFVKRLNMMALVPRGGIEVSAAAATPNGQLLLVDTAG---FVYSIDVDAPRVTFWFDASTQLGE 893

  Fly  1071 PSDIAIRDNDFYVCDFKGHCVAVFQDDGTFLYRIGNEKVTCFPNGIDISNAGDVLIGDSHGNRFH 1135
            .||:|:.||..|:.|||.|||.|:..:|.|:.::|....|.:|.|||:|.||:||:.|:|||..|
Worm   894 ASDVAMFDNLIYITDFKHHCVQVYTSEGKFIRKMGEPSQTPYPIGIDVSKAGEVLVADTHGNHLH 958

  Fly  1136 VACYSREGALQSEFECPHVKVSRCCGLKITSEGYVVTLAKNNHHVLVLNTL 1186
            |..:|.||.....|.....::|||.||:|...|::|||.|:||.:.|...|
Worm   959 VVVFSPEGQHIHSFTHNEFRLSRCVGLRIAKSGHIVTLCKHNHTLFVFKPL 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	22/90 (24%)
		BBOX	321..360	CDD:237988	11/38 (29%)
		BBC	369..494	CDD:128778	25/126 (20%)
		NHL_brat_like	913..1186	CDD:271329	103/289 (36%)
		NHL repeat	936..972	CDD:271329	15/35 (43%)
		NHL repeat	983..1025	CDD:271329	14/43 (33%)
		NHL repeat	1028..1064	CDD:271329	12/43 (28%)
		NHL repeat	1068..1107	CDD:271329	17/38 (45%)
		NHL repeat	1112..1151	CDD:271329	19/38 (50%)
		NHL repeat	1157..1183	CDD:271329	13/25 (52%)
nhl-2	NP_498026.1	RING	62..>86	CDD:214546	11/23 (48%)
		BBOX	173..217	CDD:197662	18/43 (42%)
		BBOX	233..272	CDD:197662	11/43 (26%)
		BBC	280..406	CDD:128778	25/127 (20%)
		NHL_brat_like	729..1009	CDD:271329	102/284 (36%)
		NHL repeat	754..788	CDD:271329	15/35 (43%)
		NHL repeat	799..843	CDD:271329	14/43 (33%)
		NHL repeat	846..887	CDD:271329	12/43 (28%)
		NHL repeat	891..930	CDD:271329	17/38 (45%)
		NHL repeat	935..974	CDD:271329	19/38 (50%)
		NHL repeat	980..1006	CDD:271329	13/25 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160181
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62415
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG29138
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	1	1.000	-	-		FOG0014401
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.820