DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-P26 and F43C11.8

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_494244.2	Gene:	F43C11.8 / 173590	WormBaseID:	WBGene00018385	Length:	323	Species:	Caenorhabditis elegans

Alignment Length:	340	Identity:	69/340 - (20%)
Similarity:	113/340 - (33%)	Gaps:	113/340 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 FIECPVCKQETPLGPKGIKALPCDYIVTNILDLSNLESEHIVCTSCKSKEEAISRCNDCANFLCN 284
            ||||.:|.:                      |.|:            :.:|.|.|...|.:.:|:
Worm     3 FIECEICNE----------------------DFSS------------ATDENIPRILRCGHTICH 33

  Fly   285 GCDNAHKYMR--------CFENHHVVRIEDLTKN-------------VHDKLIIHKPVFCPQHVS 328
            ||  |.|.::        |.|..:|..::||.||             ..:|..|..|..|..|
Worm    34 GC--AEKLLQNSMILCPFCREATNVSTVKDLQKNFALLQAVEHAKTRTEEKDPIDSPPKCASH-- 94

  Fly   329 ENLKYYCFTCQVPTCNDCLLSDHKGSDHHYETATVAEQAVRADLEETLSDTLKKADYCNDAGSNL 393
             ...:..|.|..|||:.                               ||.| ....|.:.|::.
Worm    95 -QYNFAEFVCIEPTCSS-------------------------------SDKL-MCRTCEEFGAHA 126

  Fly   394 GSALTELQSQHDTVRQ-------QIEDAYKCYKRMLESIKDQMLNEL--GRLHSDRELKIMDLMQ 449
            |.....|||:...:||       :.||........:|.|....|..|  |.:..::::.|:....
Worm   127 GHNRGLLQSEAAKLRQFLSGKLSRSEDLASKIDANIEKIGTAQLTNLDDGEVFQEKKVSIIAFYA 191

  Fly   450 SMENTMGKLQHAAQFGQRAVDKANSIEFLLLKPIISAQC---------LNLMEQTPKCD---INY 502
            |:..|:..|::.|....:.:.:.|.....||...:|...         |.|..:....|   :|.
Worm   192 SIRETLDALENDALATLQNIAETNFFTNDLLIAELSESLNRQKRKSAELKLFMKMSNADLLAVNS 256

  Fly   503 QLQFDSKPEMFEQFA 517
            .|:..|:.|::.:||
Worm   257 ALEVSSENELWTEFA 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	5/9 (56%)
		BBOX	321..360	CDD:237988	7/38 (18%)
		BBC	369..494	CDD:128778	29/142 (20%)
		NHL_brat_like	913..1186	CDD:271329
		NHL repeat	936..972	CDD:271329
		NHL repeat	983..1025	CDD:271329
		NHL repeat	1028..1064	CDD:271329
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
F43C11.8	NP_494244.2	RING_Ubox	5..52	CDD:388418	15/82 (18%)
		modified RING-HC finger (C3HC3D-type)	6..50	CDD:319361	13/79 (16%)
		Bbox2_TRIM23_C-IX_rpt2	88..137	CDD:380832	17/83 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010