DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-P26 and nhl-3

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001040817.2	Gene:	nhl-3 / 173452	WormBaseID:	WBGene00003599	Length:	698	Species:	Caenorhabditis elegans

Alignment Length:	347	Identity:	61/347 - (17%)
Similarity:	123/347 - (35%)	Gaps:	88/347 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 PRILSCLHVFCEDCLQ--AVVSKDTMSASSPNSCSSSSFDGSEHQNRLSAVFIECPVCKQETPLG 233
            |::|.|.|..|..|:.  |.:|.:|...:                       :.||:|::..|:.
Worm    39 PKLLPCSHSVCLFCVTQLAELSPETQPPT-----------------------LRCPLCREVCPIP 80

  Fly   234 PKGIKALPCDYIVTNILDLSNLESEHIVCTSCKSKEEAISRCNDCANFLCNGCDNAHKYMRCFEN 298
            ..|:...|..:.:..:||:..::.:.:|.:......:.:..|..|....|..|.::....:| :.
Worm    81 AGGVILFPAAFFINQLLDVMQIQRKDVVPSCSNHPTDQLLYCETCDLVFCENCQDSVVNKKC-DE 144

  Fly   299 HHVVRIEDLTKNVHDKLIIHKP-----VFCPQHVSENLKYYCFTCQVPTCNDCLLSDHKGSDHHY 358
            |.||.:....|.: .::::::.     .....||:.|.:.......|              |...
Worm   145 HTVVPLSIAIKRM-SEIVVYRAKGRLRALDDAHVTVNREIVQLDGNV--------------DKIV 194

  Fly   359 ETATVAEQAV-------RADLEETL---SDTLKKADYCNDAGSNLGSALTELQSQHDTVRQQIED 413
            |....|.|.|       |..|.||:   .|..:|.         |...|..:|.:...:::::|.
Worm   195 EQINAAIQEVSNLVENRRRVLIETVRVRRDEKRKV---------LKDQLEVIQDEKKKLQKELES 250

  Fly   414 AYKCYKRMLESIKD-------------QMLNELGRLHSDRELKIMDLMQSMENTMGKLQHAAQF- 464
            .....:.|...:||             ...|...|::::.|..::|:.::: |..|||..:..|
Worm   251 CKMDIRSMARQLKDGNSDDNWQRRIIEPRENAFLRINTNSEQMLVDVERNL-NEFGKLYASNTFP 314

  Fly   465 --------GQRAVDKANSIEFL 478
                    .|..:...||:..:
Worm   315 GTSTVEAPAQMGIHVENSLTLI 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	12/60 (20%)
		BBOX	321..360	CDD:237988	5/38 (13%)
		BBC	369..494	CDD:128778	25/135 (19%)
		NHL_brat_like	913..1186	CDD:271329
		NHL repeat	936..972	CDD:271329
		NHL repeat	983..1025	CDD:271329
		NHL repeat	1028..1064	CDD:271329
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
nhl-3	NP_001040817.2	RING-HC_TRIM32_C-VII	24..74	CDD:319501	11/57 (19%)
		Bbox_SF	111..>134	CDD:381767	3/22 (14%)
		Smc	<164..310	CDD:224117	30/169 (18%)
		Filamin	<344..422	CDD:366210
		NHL	452..696	CDD:302697
		NHL repeat	489..528	CDD:271320
		NHL repeat	530..570	CDD:271320
		NHL repeat	572..610	CDD:271320
		NHL repeat	621..659	CDD:271320
		NHL repeat	670..695	CDD:271320
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010