DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and TRIM71

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001034200.1	Gene:	TRIM71 / 131405	HGNCID:	32669	Length:	868	Species:	Homo sapiens

Alignment Length:	1235	Identity:	235/1235 - (19%)
Similarity:	377/1235 - (30%)	Gaps:	536/1235 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SNTSSSSSSSSSSSSSSGSCSGSGTDTDTGKGSSNVGSLDVTSSSSIGSETSISSTGSTAIAGPS 108
            ||:|:|||||.:|:||.|...|.|.
Human    27 SNSSASSSSSQTSTSSGGGGGGPGA---------------------------------------- 51

  Fly   109 TLLDDSNSSGLGLVVDVDSNGSSQELSSHGVTELDSLEDSCSGLMIKDGDKLCKLCSLRLVMPRI 173
                                                                   .:.||   .:
Human    52 -------------------------------------------------------AARRL---HV 58

  Fly   174 LSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQNRLSA---------VFIECPVCKQE 229
            |.|||.||..||:|                          :||.|         :.:.||||.|:
Human    59 LPCLHAFCRPCLEA--------------------------HRLPAAGGGAAGEPLKLRCPVCDQK 97

  Fly   230 TPLG-PKGIKALPCD-YIVTNILDL------------------------SN-------------- 254
            ..|. ..|:.|||.. ::::|:||.                        ||
Human    98 VVLAEAAGMDALPSSAFLLSNLLDAVVATADEPPPKNGRAGAPAGAGGHSNHRHHAHHAHPRASA 162

  Fly   255 ------------------------------LESEHIVCTSCKSKEEAISRCNDCANFLCNGCDNA 289
                                          |...| .|:||.....|.|||.||...||:.|..|
Human   163 SAPPLPQAPQPPAPSRSAPGGPAASPSALLLRRPH-GCSSCDEGNAASSRCLDCQEHLCDNCVRA 226

  Fly   290 HKYMRCFENHHVVR--IEDLTKNVHDKLIIHKPV----------------FCPQHVSENLKYYCF 336
            |:.:|..::|::.|  ..........:|.:..|.                ||..|..|.|..||.
Human   227 HQRVRLTKDHYIERGPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCD 291

  Fly   337 TCQVPTCNDCLLSDHKGSDHHYETATVAEQAVRADLEETLSD----TLKKADYCNDAGSNLGSAL 397
            ||.||.|.:|.:..|.|....|             |:|.|.|    |::..     |.:..|...
Human   292 TCSVPICRECTMGRHGGHSFIY-------------LQEALQDSRALTIQLL-----ADAQQGRQA 338

  Fly   398 TELQ-SQHDTVRQQIEDAYKC-----------YKRMLESIKDQMLNELGRLHSDRELKIMDL--- 447
            .:|. .|..||.:|:|...|.           :|:.||..:.::|.::.::   |::|...|
Human   339 IQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKI---RQVKAKSLYLQ 400

  Fly   448 MQSMENTMGKLQHAAQFGQRAVDKANSIEFLLLKPIISAQCLNLMEQTPKCDINYQLQFDSKPEM 512
            ::.:...:.||:......|:.:::..:::.||
Human   401 VEKLRQNLNKLESTISAVQQVLEEGRALDILL--------------------------------- 432

  Fly   513 FEQFAREMFGKFQTDHIDSSPKKLGMTQQLQQQQQQQQQLQQQQHQHQHQVQQQQHHHQQQQQQK 577
                ||:.                 |..|:|:.:..:..|                    |.|:.
Human   433 ----ARDR-----------------MLAQVQELKTVRSLL--------------------QPQED 456

  Fly   578 QQVQHQQQQQKLQLQQQQQHQHNSNNLIVGHRGSSSVQGRLTSAVFSPISLPSSLQSSFDGDTNS 642
            .:|......|.|.|                   :....|.::|..|:|::     :::.||...:
Human   457 DRVMFTPPDQALYL-------------------AIKSFGFVSSGAFAPLT-----KATGDGLKRA 497

  Fly   643 V---MSNFSMM----DSPPQPSSQQQLPSAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQQHQVQQ 700
            :   :::|:::    |..|:.|....:                 .||||.
Human   498 LQGKVASFTVIGYDHDGEPRLSGGDLM-----------------SAVVLG--------------- 530

  Fly   701 QQQQQVLHQPTSAQSMPQQLGQLVAPQGIVQQAGHVNLNAGPGPNISINGLGAGGPPPSFSMLEY 765
                            |.  |.|...:...||.|...::..|    .:.|
Human   531 ----------------PD--GNLFGAEVSDQQNGTYVVSYRP----QLEG--------------- 558

  Fly   766 NISRLASLTETMPDTLNDALAVGGGAAGPVPNVVAQVPGGSAVTGAAVVGASHAHQQQSQAVM-- 828
              ..|.|:|.......|....|             .|..|.:..|..:.|.|...:..|...:
Human   559 --EHLVSVTLCNQHIENSPFKV-------------VVKSGRSYVGIGLPGLSFGSEGDSDGKLCR 608

  Fly   829 P-ASAVTPTQPITLADILSGDQRALNNLQALAKLGLNNNDFCMPPATSPSLQSLNPIVGGVEDMG 892
            | ..:|.....|.:||      |:.|.:|.....|.
Human   609 PWGVSVDKEGYIIVAD------RSNNRIQVFKPCGA----------------------------- 638

  Fly   893 LNNFHAVAAPGTTSVVTGRNKATPMQIRCKFGSLGTAKGQFNSPHGFCLGVDEEIIVADTNNHRI 957
               ||.                       |||:||:..|||:.|.|........|:|||.:||||
Human   639 ---FHH-----------------------KFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRI 677

  Fly   958 EVFDKMGALKFQFGVAGKEEGQLWYPRKVAVMHNNGKFVVCDRGNERSRMQIFSKCGHFMRKIAI 1022
            ::|...|....:||..|.:.||..||..||| ::.||.:|.|..|.  |:|:|...|.|:.|...
Human   678 QIFTFEGQFLLKFGEKGTKNGQFNYPWDVAV-NSEGKILVSDTRNH--RIQLFGPDGVFLNKYGF 739

  Fly  1023 -----RYIDIVAGLAVTAKGHIVAVDSVSPTVFVISEEGELVRWFDC-----SDYMREPSDIAI- 1076
                 ::.|...|:|...:||:|..|..:..:.||..:.:..|:...     ..::| |..:|:
Human   740 EGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQFLR-PQGVAVD 803

  Fly  1077 RDNDFYVCDFKGHCVAVFQDDGTFLYRIGNEKVTCF-----PNGIDISNAGDVLIGDSHGNRFHV 1136
            ::....|.|.:.|.|.:|:.:|:||.:.|.:. :.|     |:||.|:..|.:::.|...||..|
Human   804 QEGRIIVADSRNHRVQMFESNGSFLCKFGAQG-SGFGQMDRPSGIAITPDGMIVVVDFGNNRILV 867

Fly 1137 1136
Human 868 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	19/80 (24%)
		BBOX	321..360	CDD:237988	16/54 (30%)
		BBC	369..494	CDD:128778	26/143 (18%)
		NHL_brat_like	913..1186	CDD:271329	73/240 (30%)
		NHL repeat	936..972	CDD:271329	13/35 (37%)
		NHL repeat	983..1025	CDD:271329	15/46 (33%)
		NHL repeat	1028..1064	CDD:271329	9/35 (26%)
		NHL repeat	1068..1107	CDD:271329	12/39 (31%)
		NHL repeat	1112..1151	CDD:271329	10/30 (33%)
		NHL repeat	1157..1183	CDD:271329
TRIM71	NP_001034200.1	RING-HC_TRIM71_C-VII	8..97	CDD:319503	32/193 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..49		12/21 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..189		2/61 (3%)
		Bbox1_TRIM71_C-VII	198..240	CDD:380870	16/41 (39%)
		Bbox2_TRIM71_C-VII	277..322	CDD:380854	20/57 (35%)
		BBC	314..444	CDD:128778	31/191 (16%)
		Filamin	479..580		26/189 (14%)
		Filamin	482..577	CDD:395505	24/170 (14%)
		NHL_TRIM71_like	584..868	CDD:271324	88/350 (25%)
		NHL 1	593..636		11/48 (23%)
		NHL repeat	609..648	CDD:271324	15/99 (15%)
		NHL 2	640..683		20/65 (31%)
		NHL repeat	656..695	CDD:271324	14/38 (37%)
		NHL 3	687..730		18/45 (40%)
		NHL repeat	703..739	CDD:271324	15/38 (39%)
		WD40 repeat	704..740	CDD:293791	14/38 (37%)
		NHL 4	734..777		10/42 (24%)
		NHL repeat	747..787	CDD:271324	10/39 (26%)
		NHL 5	781..824		9/43 (21%)
		NHL repeat	796..826	CDD:271324	8/30 (27%)
		NHL 6	828..868		12/41 (29%)
		NHL repeat	842..868	CDD:271324	9/26 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6561
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920