DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-P26 and ftr80

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	XP_017214326.1	Gene:	ftr80 / 101883527	ZFINID:	ZDB-GENE-090511-1	Length:	584	Species:	Danio rerio

Alignment Length:	344	Identity:	74/344 - (21%)
Similarity:	127/344 - (36%)	Gaps:	98/344 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 CKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQNRLSAVFIECPV 225
            |.:|...|..|...:|.|.||.|||                  :..:||.:.:...|     ||.
Zfish    13 CPICLHLLKNPVTTTCGHSFCMDCL------------------NGFWDGDDQKGVYS-----CPQ 54

  Fly   226 CKQETPLGP------------KGIKA------LPCDYIVTNILDLS-NLESEHIVCTSCKSKEEA 271
            |:......|            :|:|.      .|....|:.:|..: :::.|..:||..|.|  |
Zfish    55 CRHSFSPRPDLCRNIVLAAVVEGMKIKTPEKDAPEKASVSPVLSFAMSVDVECDICTETKLK--A 117

  Fly   272 ISRCNDCANFLCNGCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHKPVFCPQHVSENLKYYCF 336
            |..|..|....|......|......:.|   ::.:.:..:.|::       |.|| .:.|:.||.
Zfish   118 IKSCLVCLASYCESHIQTHYTSPALKWH---KLANASPRLLDQI-------CSQH-HKPLELYCC 171

  Fly   337 TCQVPTCNDCLLSDHKGSDHHYETATVAEQAVRADLEETLSDTLKKADYCNDAGSNLGSALTELQ 401
            ..:...|..|.|.:|:   :|..|:..||   |.:::|.|.  ||:            ..|.|..
Zfish   172 QDRQLICMQCALINHQ---NHSMTSPAAE---RQNIQEQLK--LKR------------DGLQEDV 216

  Fly   402 SQHDTVRQQIEDAYKCYKRMLESIK---DQMLNELGRLHS--DRELKIMDLMQSMENTMGKLQHA 461
            .|.:...::::.|...|||..::..   ::|..|  ::||  .|...|..::::.||.
Zfish   217 LQREVKVKELKQAKDFYKRSTQAAVVHCEEMFTE--QIHSMGKRRAGITKMIRAQENV------- 272

  Fly   462 AQFGQRAVDKANSIEFLLL 480
                     :.|.:|.|:|
Zfish   273 ---------EVNRVEDLIL 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	17/68 (25%)
		BBOX	321..360	CDD:237988	11/38 (29%)
		BBC	369..494	CDD:128778	24/117 (21%)
		NHL_brat_like	913..1186	CDD:271329
		NHL repeat	936..972	CDD:271329
		NHL repeat	983..1025	CDD:271329
		NHL repeat	1028..1064	CDD:271329
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
ftr80	XP_017214326.1	RING	13..55	CDD:302633	16/64 (25%)
		zf-B_box	157..193	CDD:279037	11/46 (24%)
		SPRY	388..576	CDD:295394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR25462
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100