DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and TRIM28

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	XP_024307077.1	Gene:	TRIM28 / 10155	HGNCID:	16384	Length:	872	Species:	Homo sapiens

Alignment Length:	928	Identity:	186/928 - (20%)
Similarity:	301/928 - (32%)	Gaps:	342/928 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SSSSSSSSSSSSSSGSCSGSGTDTDTGKGSSNVGSLDVTSSSSIGSETSISSTGSTAIAGPSTLL 111
            |::::|::::|::|||         .|.|..:.|....:::.|..:..|.|:..|:...|
Human     4 SAAAASAAAASAASGS---------PGPGEGSAGGEKRSTAPSAAASASASAAASSPAGG----- 54

  Fly   112 DDSNSSGLGLVVDVDSNGSSQELSSHGVTELDSLEDSCSGLMIKDGDKLCKLCSLRL---VMPRI 173
                                      |...|:.||.             |.:|..||   ..||:
Human    55 --------------------------GAEALELLEH-------------CGVCRERLRPEREPRL 80

  Fly   174 LSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQNRLSAVFIECPVCKQET-------- 230
            |.|||..|..||         ..::|.:.:||...|:.....:    ::||||||:.
Human    81 LPCLHSACSACL---------GPAAPAAANSSGDGGAAGDGTV----VDCPVCKQQCFSKDIVEN 132

  Fly   231 -PLGPKGIKALPCDYIVTNILDLSNLESEHIVCTSCKSKEEAISRCNDCANFLCNGCDNAHKYMR 294
             .:...|.||      .|:..|.:.      .||||:....|.|.|.:|:..||..|..||:.::
Human   133 YFMRDSGSKA------ATDAQDANQ------CCTSCEDNAPATSYCVECSEPLCETCVEAHQRVK 185

  Fly   295 CFENHHVVRIEDLTKNVHDKLIIHKPVFCPQHVSENLKYYCFTCQVPTCNDCLLSDHKGSDHHYE 359
             :...|.||.....|:...:    :.|:|..|..|.|..:|.:|...||.||.|:.||  ||.|:
Human   186 -YTKDHTVRSTGPAKSRDGE----RTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHK--DHQYQ 243

  Fly   360 TATVAEQAVRADLEETLSDTLKKADYCNDAGSNLGSALTELQSQHDTVRQQIEDAYKCYKRMLES 424
               ..|.||| :..:.|:..:|:          ||.....||.....||..|.......||:...
Human   244 ---FLEDAVR-NQRKLLASLVKR----------LGDKHATLQKSTKEVRSSIRQVSDVQKRVQVD 294

  Fly   425 IKDQM------LNELGRLHSDRELKIMDLMQS-MEN---TMGKLQ----HAAQFGQRAVDKANSI 475
            :|..:      ||:.||:..:...|:.:..|. :|.   ||.|:|    |..:|...|::..|:.
Human   295 VKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLERQHWTMTKIQKHQEHILRFASWALESDNNT 359

  Fly   476 EFLLLKPIISAQCLNLMEQ-----TPKCDINYQLQFDSKPEMFEQFAREMFGKFQTDHIDSSPKK 535
            ..||.|.:|..|....::.     .|..::.:|...::..:     :.|.|||
Human   360 ALLLSKKLIYFQLHRALKMIVDPVEPHGEMKFQWDLNAWTK-----SAEAFGK------------ 407

  Fly   536 LGMTQQLQQQQQQQQQLQQQQHQHQHQVQQQQHHHQQQQQQKQQVQHQQQQQKLQLQQQQQHQHN 600

Human   408 ----------------------------------------------------------------- 407

  Fly   601 SNNLIVGHRGSSSVQGRLTSAVFSPISLPSSLQSSFDGDTN--SVMSNFSMMDSPPQPSSQQQLP 663
                ||..|..::..|   .|..:|...|..|.....|.:.  .|...:.........||.:...
Human   408 ----IVAERPGTNSTG---PAPMAPPRAPGPLSKQGSGSSQPMEVQEGYGFGSGDDPYSSAEPHV 465

  Fly   664 SAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQQHQVQQQQQQQVLHQPTSAQSMPQQLGQLVAPQG 728
            |..::|:..:                                               |::   .|
Human   466 SGVKRSRSGE-----------------------------------------------GEV---SG 480

  Fly   729 IVQQAGHVNLNAGPGPNISINGLGAGGPPPSFSML------EYNISRLASLTETMPDTLNDALAV 787
            ::::...|:|.     .:.:: |.|...||.|.:.      :||:..:.          ..|.|.
Human   481 LMRKVPRVSLE-----RLDLD-LTADSQPPVFKVFPGSTTEDYNLIVIE----------RGAAAA 529

  Fly   788 GGGAAGPVPNVVAQVPGGSAVTGAAVVGASHAHQQQSQAVM---PASAVTP-TQPITLADILSGD 848
            ..|..|..|   |..||...:.|.|:|     .:::::|.:   |.:...| |:|:
Human   530 ATGQPGTAP---AGTPGAPPLAGMAIV-----KEEETEAAIGAPPTATEGPETKPV--------- 577

  Fly   849 QRALNNLQALAKLGLNNNDFCMPPATSPSLQSLNPIVGGVEDMGLNNFHAVAAPGTTSVVTG--- 910
                  |.|||:         .|.|..|.|.|    ..|....||.    |.||..||...|
Human   578 ------LMALAE---------GPGAEGPRLAS----PSGSTSSGLE----VVAPEGTSAPGGGPG 619

  Fly   911 --RNKATPMQIRCKFGSL 926
              .:.||..::..|.|.|
Human   620 TLDDSATICRVCQKPGDL 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	23/74 (31%)
		BBOX	321..360	CDD:237988	17/38 (45%)
		BBC	369..494	CDD:128778	33/138 (24%)
		NHL_brat_like	913..1186	CDD:271329	5/14 (36%)
		NHL repeat	936..972	CDD:271329
		NHL repeat	983..1025	CDD:271329
		NHL repeat	1028..1064	CDD:271329
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
TRIM28	XP_024307077.1	RING-HC_TIF1beta	62..124	CDD:319679	25/87 (29%)
		RING-HC finger (C3HC4-type)	65..120	CDD:319679	19/67 (28%)
		BBOX	148..184	CDD:197662	14/41 (34%)
		BBOX	207..245	CDD:237988	17/42 (40%)
		BBC	252..378	CDD:128778	32/135 (24%)
		BASP1	<525..620	CDD:330577	34/134 (25%)
		PHD_TIF1beta	627..669	CDD:277093	3/11 (27%)
		Bromodomain	696..839	CDD:321986
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910