DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and ftr30

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	XP_003198033.2	Gene:	ftr30 / 100535574	ZFINID:	ZDB-GENE-070912-106	Length:	560	Species:	Danio rerio

Alignment Length:	707	Identity:	132/707 - (18%)
Similarity:	226/707 - (31%)	Gaps:	254/707 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 CKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQNRLSAVFIECPV 225
            |.:|...|..|..:.|.|.:|..|:              ..|.:     .|.|.|:    ..||.
Zfish    18 CSVCLDLLKDPVSIPCGHSYCMSCI--------------TDCWN-----QEDQKRV----YSCPQ 59

  Fly   226 CKQETPLGPKGIKALPCDYIVTNILD---LSNLES-------------EHIVCTSCKSKEEAISR 274
            |:|.....|    ||..:.::..:|:   .|.|::             |..|||..|::  |:..
Zfish    60 CRQTFSPRP----ALAKNTMLAEVLEKQQKSKLQAAGPAQSPAASGDVECDVCTGAKNR--AVKS 118

  Fly   275 CNDCANFLCNGCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHK--PVFCPQHVSENLKYYCFT 337
            |..|.|..|:.....|:.:.....|.|:.            ..||  .:.|||| .:.|:.:|.|
Zfish   119 CLVCLNSYCHTHFQLHQQLNPGNQHKVIE------------ATHKLQEMICPQH-KKLLEIFCRT 170

  Fly   338 CQVPTCNDCLLSDHKGSDHHYETATVAEQAVRADLEETLSDTLKKADYCNDAGSNLGSALTELQS 402
            .....|..|::..||   ||   .||:..|.|.:|:..|.:|          .|.....|.|.|.
Zfish   171 DHCCICYLCMVDQHK---HH---DTVSAAAERTELQSRLRET----------QSRFQQRLQERQK 219

  Fly   403 QHDTVRQQIEDAYKCYKRMLESIKDQMLNELGRLHSDRELKIMDLMQSMENTMGKLQHAAQFGQR 467
            :.:.:|:.:|.    :||..::..|         |::|  ....|:..:|.:..:|....:.|::
Zfish   220 ELEELREAVES----HKRSAQAAVD---------HTER--IFTQLICWIERSRSELTQMIRDGEK 269

  Fly   468 -AVDKANSIEFLLLKPIISAQCLNLMEQTPKCDINYQLQFDSKPEMFEQFAREMFGKFQTDHIDS 531
             ||..|.                                        |:..|
Zfish   270 TAVSGAE----------------------------------------ERLER------------- 281

  Fly   532 SPKKLGMTQQLQQQQQQQQQLQQQQHQHQHQVQQQQHHHQQQQQQKQQVQHQQQQQKLQLQQQQQ 596
                  :.|::...:::..:|:|..|...|                  :...|..|.|.:..
Zfish   282 ------LEQEINDLRRRNAELEQLSHTEDH------------------IHFLQSLQSLSVPP--- 319

  Fly   597 HQHNSNNLIVGHRGSSSVQGRLTSAVFSPISLPSSLQSSFDGDTNSV------MSNF---SMMDS 652
                      |...||              |..||.|.:||....||      :..|   .|...
Zfish   320 ----------GSTDSS--------------SFISSSQLAFDQLAESVSRLRDKLQQFCTEEMKTI 360

  Fly   653 PPQPSSQQQLPSAQQQSQQQQQQQQQQ---------QAVVLQQ----------VQQQQKHQ---- 694
            ..:.||..::|:.:.|:::|..|..||         ..:||.:          ||....|.
Zfish   361 SSRVSSISRIPAPEAQTREQFLQYSQQFTLDPNTVNNCLVLSEGNTAVDYKDSVQPYPDHPDRFD 425

  Fly   695 -QHQV-----------QQQQQQQVLHQPTSAQSMPQQLGQLVAPQGIVQQAGHVNLN-------- 739
             .:||           .:.:...|::...|.:|:.::...:....|...|:..:..:
Zfish   426 CSYQVFCRESVCGRSYWELEWSGVVYLSVSYKSISRKGRNIECGFGNNDQSWSLECSPYSFSFWH 490

  Fly   740 -----AGPGPNISINGLGAGGPPPSFSMLEYNIS-RLASLTETMPDTLNDALAVGGG 790
                 |.|.|::|.:.:|......:.::..|::| ...||..|:..|....|..|.|
Zfish   491 NKIKTALPKPSVSSSRIGVYVDHSAGTLSFYSVSDTTMSLIHTLHTTFTHTLYPGFG 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	16/68 (24%)
		BBOX	321..360	CDD:237988	13/38 (34%)
		BBC	369..494	CDD:128778	22/125 (18%)
		NHL_brat_like	913..1186	CDD:271329
		NHL repeat	936..972	CDD:271329
		NHL repeat	983..1025	CDD:271329
		NHL repeat	1028..1064	CDD:271329
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
ftr30	XP_003198033.2	RING	18..60	CDD:302633	14/64 (22%)
		zf-B_box	153..191	CDD:279037	14/44 (32%)
		IncA	<173..299	CDD:282066	35/215 (16%)
		Exonuc_VII_L	<189..>234	CDD:280721	14/58 (24%)
		SPRY_PRY_SNTX	378..556	CDD:294002	30/170 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR25462
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100