DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and ftr95

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	XP_009297237.1	Gene:	ftr95 / 100005532	ZFINID:	ZDB-GENE-070912-105	Length:	558	Species:	Danio rerio

Alignment Length:	438	Identity:	95/438 - (21%)
Similarity:	161/438 - (36%)	Gaps:	111/438 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 CKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQNRLSAVFIECPV 225
            |.:|...|..|..:.|.|.:|..|:              ..|.:     .|.|.|:    ..||.
Zfish    14 CAVCLDLLKDPVSIPCGHSYCMSCI--------------TDCWN-----QEDQKRV----YSCPQ 55

  Fly   226 CKQETPLGPKGIKALPCDYIVTNILD---LSNLES-------------EHIVCTSCKSKEEAISR 274
            |:|.....|    ||..:.::..:|:   .|.|::             |..|||..|::  |:..
Zfish    56 CRQTFSPRP----ALAKNTMLAEVLEKLQKSKLQAAGPAQSPAASGDVECDVCTGAKNR--AVKS 114

  Fly   275 CNDCANFLCNGCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHKPVFCPQHVSENLKYYCFTCQ 339
            |..|.|..|      |.:.:..:..|......:|:..| ||   :.:.|||| .:.|:.:|.|..
Zfish   115 CLVCLNSYC------HTHFQRHQEIHQGNRHKVTEATH-KL---QEMICPQH-KKLLEIFCRTDH 168

  Fly   340 VPTCNDCLLSDHKGSDHHYETATVAEQAVRADLEETLSDTLKKADYCNDAGSNLGSALTELQSQH 404
            ...|..|||..||   ||   .||:..|.|.:|:..|.:|          .|.....|.|.|.:.
Zfish   169 CCICYLCLLDQHK---HH---DTVSAAAERTELQSRLRET----------QSRFQQRLQERQKEL 217

  Fly   405 DTVRQQIEDAYKCYKRMLESIKD-------QMLNELGRLHSDRELKIMD-----------LMQSM 451
            :.:|:.:|.    :||..::..|       |::..:.|..|:....|.|           .::.:
Zfish   218 EELREAVES----HKRSAQAAVDHTERIFTQLICWIERSRSELTQMIRDGEKTAVSGAEERLERL 278

  Fly   452 ENTMGKLQHAAQFGQRAVDKANSIEFLLLKPIISAQCLNLMEQTPKCD------INYQLQFDSKP 510
            |..:..|:......::.....:.|.||        |.|..:...|...      .:.||.||...
Zfish   279 EQEINDLRRRNAELEQLSHTEDHIHFL--------QSLQSLSVPPGSTDSSSFISSSQLAFDQLA 335

  Fly   511 EMFEQFAREMFGKFQTDHIDSSPKKLGMTQQL--QQQQQQQQQLQQQQ 556
            |...:. |:...:|.|:.:.:...::....::  .:.|.::|.||..|
Zfish   336 ESVSRL-RDKLQQFCTEEMKTISSRVSSISRIPAPEPQTREQFLQYSQ 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	16/68 (24%)
		BBOX	321..360	CDD:237988	15/38 (39%)
		BBC	369..494	CDD:128778	25/142 (18%)
		NHL_brat_like	913..1186	CDD:271329
		NHL repeat	936..972	CDD:271329
		NHL repeat	983..1025	CDD:271329
		NHL repeat	1028..1064	CDD:271329
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
ftr95	XP_009297237.1	zf-C3HC4_4	14..56	CDD:291880	14/64 (22%)
		zf-B_box	149..187	CDD:279037	16/44 (36%)
		IncA	<169..295	CDD:282066	31/145 (21%)
		Exonuc_VII_L	<185..>230	CDD:280721	14/58 (24%)
		SPRY_PRY_SNTX	374..554	CDD:294002	4/9 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR25462
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100