DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-P26 and trim2a

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001014393.1	Gene:	trim2a / 100003782	ZFINID:	ZDB-GENE-050327-99	Length:	744	Species:	Danio rerio

Alignment Length:	1055	Identity:	201/1055 - (19%)
Similarity:	349/1055 - (33%)	Gaps:	360/1055 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 MIKDGDK---LCKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQN 214
            :::..||   :|.:|..|...|::|.|||.|||.|||..:...:::.|
Zfish    12 VVRQIDKQFLICSICLDRYNNPKVLPCLHTFCERCLQNYIPPHSLTLS----------------- 59

  Fly   215 RLSAVFIECPVCKQETPLGPKGIKALPCDYIVTNILDL------SNLESEHIVCTSCKSKEEAIS 273
                    ||||:|.:.|..||:.||..::.:||::::      |||..::
Zfish    60 --------CPVCRQTSILPEKGVAALQSNFFITNLMEVLKKSPNSNLSEDY-------------- 102

  Fly   274 RCNDCANFLCNGCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHKPVFCPQHVSENLKYYCFTC 338
              .|..|.:..|                                 :|:.||.|....:::||..|
Zfish   103 --TDAINGVATG---------------------------------QPLSCPNHGGNVMEFYCPPC 132

  Fly   339 QVPTCNDCLLSDHKGSDHHYETATVAEQAV----RADLEETLSDTLKKADYCNDAGSNLGSALTE 399
            :...|.:|.      |..|.|.|||..:.|    :|.|:|.|.....:......|...|...|.:
Zfish   133 ETAMCEECT------SGEHAEHATVPLKDVLEQHKASLQEQLDAVKNRLPEIESALEVLSEILQQ 191

  Fly   400 LQSQHDTVRQQIEDAYKCYKRMLESIKDQMLNELGRLHSDRELKIMDLMQSMENTMGKLQHAAQF 464
            |.||..::.:.|...::..::.|...|..:|.||...:..::..:...::|:......::.:..|
Zfish   192 LSSQKSSIEEMIHATFEELQKTLNVRKSVLLMELEVNYGLKQKVLQTQLESLLQGQDGIRSSCSF 256

  Fly   465 GQRAVDKANSIEFLLLKPIISAQCLNLMEQTPKCDINYQLQFDSKPEMFEQFAREMFGKFQTDHI 529
            .::|::..:..|.||:|
Zfish   257 TEQALNHGSEAEVLLVK------------------------------------------------ 273

  Fly   530 DSSPKKLGMTQQLQQQQQQQQQLQQQQHQHQHQVQQQQHHHQQQQQQKQQVQHQQQQQKLQLQQQ 594
                            :|..::|.:..:|
Zfish   274 ----------------KQMSERLDELANQ------------------------------------ 286

  Fly   595 QQHQHNSNNLIVGHRGSSSVQGRLTSAVFSPISLPSSLQSSFDGDTNSVMSNFSMMDSPPQPSSQ 659
                                                                    :.|.:|...
Zfish   287 --------------------------------------------------------ELPLRPEEN 295

  Fly   660 QQLPSAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQQHQVQQQQQQQVLHQPTSAQSMPQQLGQLV 724
            .||                                ...|:....::.:|          .||.:|
Zfish   296 NQL--------------------------------DFLVETDGLRKSIH----------NLGAIV 318

  Fly   725 APQGIVQQAGHVNLNAGPGPNISINGLGAGGPPPSFSMLEYNISRLASLTETMPDTLNDALAVGG 789
            ....:..:    .:..|.|....|                  :.:|.|:|.|..|. :..|...|
Zfish   319 TTNAVAAE----TVATGEGLRHCI------------------VGQLTSVTVTTKDR-DGGLCRTG 360

  Fly   790 GAAGPVPNVVAQVPGGSAVTGAAVVGASHAHQQQSQAVMPASAVTPTQPITLADILSGDQRALNN 854
            .|.     ::|.:   ||:.| ::||.......::.......:|......||. :...||.
Zfish   361 NAL-----LIADL---SAIDG-SIVGEGKVTDHKNGTYEFVYSVPCEGRFTLT-LKLYDQH---- 411

  Fly   855 LQALAKLGLNNNDFCMPPATSPSLQSLNPIVGGVEDMGLNNFH----AVAAPGTTSVVTGRNKAT 915
                    :..:.|.: .|..|:..||...|.........|.|    |:..| .:...||:.|..
Zfish   412 --------IRGSPFSI-RANKPTDISLTADVDKKRLKSPGNSHVKQRAIKRP-ASMYSTGKRKEN 466

  Fly   916 PMQ--IRCKFGSLGTAKGQFNSPHGFCLGVDEEIIVADTNNHRIEVFDKMGALKFQFGVAGKEEG 978
            |::  :..:.|:.|..||:|.:..|.......::::||:||..:::|...|..|.:||:.|:..|
Zfish   467 PIEDDLIFRIGTKGRNKGEFTNLQGVAASSVGKVLIADSNNQCVQIFLNDGQFKGRFGIRGRSPG 531

  Fly   979 QLWYPRKVAVMHNNGKFVVCDRGNERSRMQIFSKCGHFMRKIAIRYIDIVAGLAVTAKGHIVAVD 1043
            ||..|..||| |.:|..::.|..|:  .:.|||..|.|..||....:....|::|...|||:.||
Zfish   532 QLQRPTGVAV-HPSGDIIIADYDNK--WVSIFSSDGKFKSKIGSGKLMGPKGVSVDRNGHIIVVD 593

  Fly  1044 SVSPTVFVISEEGELVRWF----DCSDYMREPSDIAI-RDNDFYVCDFKGHCVAVFQDDGTFLYR 1103
            :.|..||:....|:||..|    :.......|...|: ::|:..|.||..|.|.||..:|.|:.:
Zfish   594 NKSCCVFIFQPNGKLVSKFGNRGNSDKQFAGPHFAAVNQNNEVIVTDFHNHSVKVFSPEGEFILK 658

  Fly  1104 I-----GNEKVTCFPNGIDISNAGDVLIGDSHGNRFHVACYSREGALQSEFECPHVKVSRCCGLK 1163
            .     ||.:... |.|:.:...|::::.|...:|..|  :...|:..|........:....||.
Zfish   659 FGSNGEGNGQFNA-PTGVAVDANGNIIVADWGNSRIQV--FDSSGSFLSYINTSADPLYGPQGLA 720

  Fly  1164 ITSEGYVVTLAKNNH 1178
            :||:|:||.....||
Zfish   721 LTSDGHVVVADSGNH 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	22/74 (30%)
		BBOX	321..360	CDD:237988	10/38 (26%)
		BBC	369..494	CDD:128778	23/124 (19%)
		NHL_brat_like	913..1186	CDD:271329	81/278 (29%)
		NHL repeat	936..972	CDD:271329	9/35 (26%)
		NHL repeat	983..1025	CDD:271329	15/41 (37%)
		NHL repeat	1028..1064	CDD:271329	14/39 (36%)
		NHL repeat	1068..1107	CDD:271329	13/44 (30%)
		NHL repeat	1112..1151	CDD:271329	8/38 (21%)
		NHL repeat	1157..1183	CDD:271329	9/22 (41%)
trim2a	NP_001014393.1	RING	23..66	CDD:238093	19/67 (28%)
		BBOX	112..153	CDD:197662	16/79 (20%)
		BBC	160..286	CDD:128778	25/189 (13%)
		IG_FLMN	324..421	CDD:214720	23/142 (16%)
		Filamin	324..417	CDD:279024	22/137 (16%)
		NHL_TRIM2_like	471..744	CDD:271330	79/271 (29%)
		YncE	486..>735	CDD:225926	73/254 (29%)
		NHL repeat	489..528	CDD:271330	10/38 (26%)
		NHL repeat	536..575	CDD:271330	15/41 (37%)
		NHL repeat	578..615	CDD:271330	14/36 (39%)
		NHL repeat	622..663	CDD:271330	12/40 (30%)
		NHL repeat	669..711	CDD:271330	8/44 (18%)
		NHL repeat	714..740	CDD:271330	9/22 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.880