DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-P26 and LOC100000832

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	XP_001340954.2	Gene:	LOC100000832 / 100000832	-ID:	-	Length:	587	Species:	Danio rerio

Alignment Length:	444	Identity:	77/444 - (17%)
Similarity:	145/444 - (32%)	Gaps:	169/444 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 LSCLHVFCEDCLQAVVSKDTMSASSP------NSCSSSSFDGSEHQNRLSAVFIECPVCKQETPL 232
            ||..|:.|..||:...:    ..|||      .||.|..:|.::|        .:||:|||.
Zfish     8 LSEEHLLCSICLEVFDN----PVSSPCGHSFCMSCISHYWDTAKH--------CQCPLCKQT--- 57

  Fly   233 GPKGIKALPCDYIVTNILDLS--------NLESEHIVCTSCKSKEEAISRCNDCANFLCNG---- 285
                .|..|..:|...:.:::        ||.:    |...:::::.|::.:      .||
Zfish    58 ----FKRKPDLHINRTLREITEQFKCMNGNLGA----CGGDEAEKDGITQES------TNGTLKR 108

  Fly   286 --------CDNAHKYMR---------CFENHHVVRIEDLTKNVH-DKLIIHKPVF---------- 322
                    .:...|.:|         |   |:....|...:..| |......|.|
Zfish   109 GQLPNQLFSEMKRKLIRRRSRDTSLAC---HNETGAEQTEQTTHADSDDTELPNFARQVSLRRYS 170

  Fly   323 ------------CPQHVSENLKYYCFTCQVPTCNDCLLSDHKGSDHHYETATVAEQ-----AVRA 370
                        ||:| ..||:.:|     .|..:|:.::.:.::|.....|.||:     .::.
Zfish   171 MCGAANAVKVPLCPKH-HRNLELFC-----RTDLECICAECEQTEHQTHNITCAEKEWQINKIKI 229

  Fly   371 DLEETLSDTLKKADYCNDAGSNLGSALTELQSQHDTVRQQIEDAYKCYKRMLESIKDQM--LNEL 433
            .:.||                                  :|::..:...:..|.||..:  :|.|
Zfish   230 SITET----------------------------------EIQEMARVRTQKAEEIKQSLIDINAL 260

  Fly   434 GRLHSDRELKIMD-LMQSMENTMGKLQHAAQFGQRAVDKANSIEFLLLKPIIS------------ 485
            .:..:.|.:::.. |:.|:|.:...|....:..:|:.:....:....|:..|:
Zfish   261 AQHEAQRSMQLFGALISSLERSQAGLLEVTEINRRSAEHQAELMIRELEQEITELRTKSTELTKL 325

  Fly   486 AQCLNLM--------EQTP-----------KCDINYQLQFDSKPEMFEQFAREM 520
            ||..|.:        ..||           .||:..:....|..::.|||..|:
Zfish   326 AQTDNYITGLKGYSDASTPVSVKDWSSVSLSCDLGTEGICASVCQLLEQFKEEL 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	19/61 (31%)
		BBOX	321..360	CDD:237988	10/60 (17%)
		BBC	369..494	CDD:128778	19/147 (13%)
		NHL_brat_like	913..1186	CDD:271329
		NHL repeat	936..972	CDD:271329
		NHL repeat	983..1025	CDD:271329
		NHL repeat	1028..1064	CDD:271329
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
LOC100000832	XP_001340954.2	RING	15..58	CDD:238093	16/61 (26%)
		BBOX	181..213	CDD:237988	9/37 (24%)
		SPRY_PRY_C-I_1	410..583	CDD:293968
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR25462
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100