DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AgaP_AGAP007538 and AMFR

DIOPT Version :9

Sequence 1:	XP_001237062.2	Gene:	AgaP_AGAP007538 / 4576491	VectorBaseID:	AGAP007538	Length:	703	Species:	Anopheles gambiae
Sequence 2:	NP_001310441.1	Gene:	AMFR / 267	HGNCID:	463	Length:	675	Species:	Homo sapiens

Alignment Length:	650	Identity:	274/650 - (42%)
Similarity:	384/650 - (59%)	Gaps:	102/650 - (15%)

- Green bases have known domain annotations that are detailed below.

Mosquito    36 GAYLKDTASFMATEPFCIWTLINTAYCCLILLGKSIQKFVFGELRISEQQHMKDKFWNFIFYKFI 100
            |...:|.|.::.::...:|.|:|||.|.|:|:.|.||..|||.||:||:||:|||||||||||||
Human    67 GPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFI 131

Mosquito   101 FVFGVVNVQYLYEVILWVSWFSALGFLHLLSQLSKDRFEYLSFSPTTPGWSHFRLISLLVA-ILA 164
            |:|||:|||.:.||::|..||:.|.||||:.||.||||||||||||||..||.|::||||| :|:
Human   132 FIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGRVLSLLVAMLLS 196

Mosquito   165 LSGLMVGISIGVGVFFGGFNTFAFMAAECILLSIRTLHVLIRYGMFLHDMRQGGIANESISWDKR 229
            ..||....|| .| :..|.:|.||||||.:|:::||.||::||.:.|.|:...|      :|:.:
Human   197 CCGLAAVCSI-TG-YTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEG------TWEGK 253

Mosquito   230 GPVAYYIELTFEVAALMVELVHYIHMMLWSNIFLSMASLVILMQLRYLLNEIQRKIKKHRNYLWV 294
            |...||.:...|:..|.::|:|:|||:|:.||:||||||||.||||||.:|:||:|::|:|||.|
Human   254 GTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRV 318

Mosquito   295 LNHMEKSYPLASSDDLKQNSDNCAICWEKMETARKLPCAHLFHNSCLQSWLEQDTSCPTCRLGLS 359
            :.:||..:.:|:.::|..|:|:|||||:.|:.||||||.||||||||:|||||||||||||:.|:
Human   319 VGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLN 383

Mosquito   360 VHQNGGPR----GSPLLPDDIRIDDQDGAVGGGGGR---TANNHFFHFNG--------------- 402
            :..|...|    |.       .:|:....|....||   ..:||||||:|
Human   384 IADNNRVREEHQGE-------NLDENLVPVAAAEGRPRLNQHNHFFHFDGDDSSMRVTAPEDVPV 441

Mosquito   403 -----------------SRYVSWLPNFSVEVTHINSMLRPSETLPITAAAVGNHTSQVRNMARHV 450
                             ||..||||:|||||.|..::      |.||.|:    .||:..||..:
Human   442 GQEVEVVDSDTDAPDLWSRIASWLPSFSVEVMHTTNI------LGITQAS----NSQLNAMAHQI 496

Mosquito   451 QEMFPRYPLSVLIGDLQISRSIEVTIDNILEGRLQVPANSPEDEDEETLGAAN-VASMAMSGSMD 514
            |||||:.|..:::.|||::||:|:|.|||||||:|||  .|....:....|.| ......|...:
Human   497 QEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVP--FPTQRSDSIRPALNSPVERPSSDQEE 559

Mosquito   515 GDNGDDDDELSGELSTRSLTNSLSASSLSSLSSPAGYEVERGTNIFGNYDALLRDDTVEEISSAT 579
            |:.....:.:..:||.| |..:|.                     ||..:  :....||:..:.
Human   560 GETSAQTERVPLDLSPR-LEETLD---------------------FGEVE--VEPSEVEDFEAR- 599

Mosquito   580 SVPLGDRFSKSPEEREKILQRRKEQLLAMARRRYLEKNKSE----LNHQPSTSATASTSSTVRHR 640
                |.|||||.:||:::|.:||::||..||:|:|.|:..:    .:..||..| :|...|:|.|
Human   600 ----GSRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDDAASESFLPSEGA-SSDPVTLRRR 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AgaP_AGAP007538	XP_001237062.2	HRD1	49..>370	CDD:227568	178/325 (55%)
		TDT	<99..211	CDD:296283	64/112 (57%)
		zf-RING_2	315..355	CDD:290367	32/39 (82%)
		CUE_AMFR	444..484	CDD:270604	21/39 (54%)
AMFR	NP_001310441.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	288	1.000	Domainoid score	I1633
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H888
Inparanoid	1	1.050	487	1.000	Inparanoid score	I1490
OMA	1	1.010	-	-		QHG55068
OrthoDB	1	1.010	-	-		D271732at33208
OrthoFinder	1	1.000	-	-		FOG0006872
OrthoInspector	1	1.000	-	-		oto161485
Panther	1	1.100	-	-	LDO	PTHR15067
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3836
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.940