Protein Alignment LOC4576491 and Amfr

DIOPT Version :10

• Sequence 1: XP_061506956.1
• Gene: LOC4576491 / 4576491
• VectorBaseID: AGAMI1_013392
• Length: 841
• Species: Anopheles gambiae
• Sequence 2: NP_035917.2
• Gene: Amfr / 23802
• MGIID: 1345634
• Length: 639
• Species: Mus musculus
• Alignment Length: 676
• Identity: 286/676 - (42%)
• Similarity: 397/676 - (58%)
• Gaps: 115/676 - (17%)

Mosquito   128 LRQMLQGGGS----DAPDEDDAREVEEGDERWLVVGNDTRSLGAYLKDTASFMATEPFCIWTLIN 188
            |.|...|.|.    .||.:.:||         |..|      |...:|.|.::.::...:|.|:|
Mouse    36 LSQPEDGSGEPEPLTAPLQPEAR---------LTAG------GPRARDVAQYLLSDSLFVWVLVN 85

Mosquito   189 TAYCCLILLGKSIQKFVFGELRISEQQHMKDKFWNFIFYKFIFVFGVVNVQYLYEVILWVSWFSA 253
            ||.|.|:|:.|.||..|||.||:||:||:||||||||||||||:|||:|||.:.||::|..||:.
Mouse    86 TACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAG 150

Mosquito   254 LGFLHLLSQLSKDRFEYLSFSPTTPGWSHFRLISLLVAILALSGLMVGISIGVGVFFGGFNTFAF 318
            |.||||:.||.||||||||||||||..||.|::|||:|:| ||...:.:...|..:..|.:|.||
Mouse   151 LVFLHLMVQLCKDRFEYLSFSPTTPMSSHGRVLSLLIAML-LSCCGLAVVCCVTGYTHGMHTLAF 214

Mosquito   319 MAAECILLSIRTLHVLIRYGMFLHDMRQGGIANESFSSFPAISWDKRGPVAYYIELTFEVAALMV 383
            ||||.:|:::||.||::||.:.|.|:...|            :|:.:|...||.:...|:|.|.:
Mouse   215 MAAESLLVTVRTAHVILRYVIHLWDLNHEG------------TWEGKGTYVYYTDFVMELALLSL 267

Mosquito   384 ELVHYIHMMLWSNIFLSMASLVILMQLRYLLNEIQRKIKKHRNYLWVLNHMEKSYPLASSDDLKQ 448
            :|:|:|||:|:.||:||||||||.||||||.:|:||:|::|:|||.|:.:||..:.:|:.::|..
Mouse   268 DLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAV 332

Mosquito   449 NSDNCAICWEKMETARKLPCAHLFHNSCLQSWLEQDTSCPTCRLGLSVHQNGGPRGSPLLPDDIR 513
            |:|:|||||:.|:.||||||.||||||||:|||||||||||||:.|::......|      :|.:
Mouse   333 NNDDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADGSRAR------EDHQ 391

Mosquito   514 ---IDDQDGAVGGGGGR---TANNHFFHFNGSRYVSWLPNFSVEVTHINSMLRPSETLPITAAAV 572
               :|:....|....||   ..:||||||:|||..||||:|||||.|..::      |.||.|:
Mouse   392 GENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNI------LGITQAS- 449

Mosquito   573 GNHTSQVRNMARHVQEMFPRYPLSVLIGDLQISRSIEVTIDNILEGRLQVP------------AN 625
               .||:..||..:|||||:.|..:::.|||::||:|:|.|||||||:|||            .|
Mouse   450 ---NSQLNAMAHQIQEMFPQVPYHLVLQDLQMTRSVEITTDNILEGRIQVPFPTQRSDSLRPALN 511

Mosquito   626 SPEDEDEETL--GAASVASMAMSGSMDGDNGDDDDELSGELSTRSLTNSLSASSLSSLSSPAGYE 688
            ||.:.....|  |.|||.:               :.:..:||.| |..:|..|           |
Mouse   512 SPVERPSPDLEEGEASVQT---------------ERVPLDLSPR-LEETLDFS-----------E 549

Mosquito   689 VERGTNIFGNYDALLRDDTVEEISSATSVPLGDRFSKSPEEREKILQRRKEQLLAMARRRYLEKN 753
            ||            |....||:..:.     |.|||||.:||:::|.:||:.||..||:|:|.|:
Mouse   550 VE------------LEPIEVEDFEAR-----GSRFSKSADERQRMLVQRKDDLLQQARKRFLNKS 597

Mosquito   754 KSELNHQPSTSATASTSS---TVRHR 776
            ..:.........:..|||   |:|.|
Mouse   598 SEDDGASERLLPSEGTSSDPVTLRRR 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LOC4576491	XP_061506956.1	None
Amfr	NP_035917.2	HRD1	82..>378	CDD:227568	171/308 (56%)
		RING-H2_AMFR	335..378	CDD:438119	34/42 (81%)
		CUE_AMFR	454..494	CDD:270604	21/39 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..531		8/45 (18%)
		G2BR	571..596	CDD:375868	11/24 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	594..620		5/25 (20%)
		VCP/p97-interacting motif (VIM). /evidence=ECO:0000250|UniProtKB:Q9UKV5	618..636		3/6 (50%)