DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AgaP_AGAP007538 and Amfr

DIOPT Version :9

Sequence 1:	XP_001237062.2	Gene:	AgaP_AGAP007538 / 4576491	VectorBaseID:	AGAP007538	Length:	703	Species:	Anopheles gambiae
Sequence 2:	NP_035917.2	Gene:	Amfr / 23802	MGIID:	1345634	Length:	639	Species:	Mus musculus

Alignment Length:	646	Identity:	283/646 - (43%)
Similarity:	393/646 - (60%)	Gaps:	79/646 - (12%)

- Green bases have known domain annotations that are detailed below.

Mosquito    12 EDDSREVEE-----GDERWLVVGNDTRSLGAYLKDTASFMATEPFCIWTLINTAYCCLILLGKSI 71
            ||.|.|.|.     ..|..|..|      |...:|.|.::.::...:|.|:|||.|.|:|:.|.|
Mouse    40 EDGSGEPEPLTAPLQPEARLTAG------GPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLI 98

Mosquito    72 QKFVFGELRISEQQHMKDKFWNFIFYKFIFVFGVVNVQYLYEVILWVSWFSALGFLHLLSQLSKD 136
            |..|||.||:||:||:||||||||||||||:|||:|||.:.||::|..||:.|.||||:.||.||
Mouse    99 QCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKD 163

Mosquito   137 RFEYLSFSPTTPGWSHFRLISLLVAILALSGLMVGISIGVGVFFGGFNTFAFMAAECILLSIRTL 201
            ||||||||||||..||.|::|||:|:| ||...:.:...|..:..|.:|.||||||.:|:::||.
Mouse   164 RFEYLSFSPTTPMSSHGRVLSLLIAML-LSCCGLAVVCCVTGYTHGMHTLAFMAAESLLVTVRTA 227

Mosquito   202 HVLIRYGMFLHDMRQGGIANESISWDKRGPVAYYIELTFEVAALMVELVHYIHMMLWSNIFLSMA 266
            ||::||.:.|.|:...|      :|:.:|...||.:...|:|.|.::|:|:|||:|:.||:||||
Mouse   228 HVILRYVIHLWDLNHEG------TWEGKGTYVYYTDFVMELALLSLDLMHHIHMLLFGNIWLSMA 286

Mosquito   267 SLVILMQLRYLLNEIQRKIKKHRNYLWVLNHMEKSYPLASSDDLKQNSDNCAICWEKMETARKLP 331
            ||||.||||||.:|:||:|::|:|||.|:.:||..:.:|:.::|..|:|:|||||:.|:.|||||
Mouse   287 SLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLP 351

Mosquito   332 CAHLFHNSCLQSWLEQDTSCPTCRLGLSVHQNGGPRGSPLLPDDIR---IDDQDGAVGGGGGR-- 391
            |.||||||||:|||||||||||||:.|::......|      :|.:   :|:....|....||
Mouse   352 CGHLFHNSCLRSWLEQDTSCPTCRMSLNIADGSRAR------EDHQGENLDENLVPVAAAEGRPR 410

Mosquito   392 -TANNHFFHFNGSRYVSWLPNFSVEVTHINSMLRPSETLPITAAAVGNHTSQVRNMARHVQEMFP 455
             ..:||||||:|||..||||:|||||.|..::      |.||.|:    .||:..||..:|||||
Mouse   411 LNQHNHFFHFDGSRIASWLPSFSVEVMHTTNI------LGITQAS----NSQLNAMAHQIQEMFP 465

Mosquito   456 RYPLSVLIGDLQISRSIEVTIDNILEGRLQVPANSPEDEDEETLGAANVASMAMSGSMDGDNGD- 519
            :.|..:::.|||::||:|:|.|||||||:|||  .|....:....|.|  |.....|.|.:.|:
Mouse   466 QVPYHLVLQDLQMTRSVEITTDNILEGRIQVP--FPTQRSDSLRPALN--SPVERPSPDLEEGEA 526

Mosquito   520 --DDDELSGELSTRSLTNSLSASSLSSLSSPAGYEVERGTNIFGNYDALLRDDTVEEISSATSVP 582
              ..:.:..:||.| |..:|..|           |||            |....||:..:.
Mouse   527 SVQTERVPLDLSPR-LEETLDFS-----------EVE------------LEPIEVEDFEAR---- 563

Mosquito   583 LGDRFSKSPEEREKILQRRKEQLLAMARRRYLEKNKSELNHQPSTSATASTSS---TVRHR 640
             |.|||||.:||:::|.:||:.||..||:|:|.|:..:.........:..|||   |:|.|
Mouse   564 -GSRFSKSADERQRMLVQRKDDLLQQARKRFLNKSSEDDGASERLLPSEGTSSDPVTLRRR 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AgaP_AGAP007538	XP_001237062.2	HRD1	49..>370	CDD:227568	174/320 (54%)
		TDT	<99..211	CDD:296283	61/111 (55%)
		zf-RING_2	315..355	CDD:290367	32/39 (82%)
		CUE_AMFR	444..484	CDD:270604	21/39 (54%)
Amfr	NP_035917.2	HRD1	82..>378	CDD:227568	171/302 (57%)
		zf-RING_2	335..375	CDD:290367	32/39 (82%)
		CUE_AMFR	454..494	CDD:270604	21/39 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..531		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..620		5/25 (20%)
		VCP/p97-interacting motif (VIM). /evidence=ECO:0000250\|UniProtKB:Q9UKV5	618..636		3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	290	1.000	Domainoid score	I1594
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H888
Inparanoid	1	1.050	486	1.000	Inparanoid score	I1481
OMA	1	1.010	-	-		QHG55068
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006872
OrthoInspector	1	1.000	-	-		oto198618
Panther	1	1.100	-	-	LDO	PTHR15067
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3836
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.930