DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta'COP and SEC27

DIOPT Version :9

Sequence 1:	NP_524836.2	Gene:	beta'COP / 45757	FlyBaseID:	FBgn0025724	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	NP_011378.1	Gene:	SEC27 / 852740	SGDID:	S000003105	Length:	889	Species:	Saccharomyces cerevisiae

Alignment Length:	899	Identity:	385/899 - (42%)
Similarity:	556/899 - (61%)	Gaps:	40/899 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LKLDIKRRLTSRSDRVKCVDLHPAEPWMLCALYNGHVHIMNYENQQMVKDFEVCDVPVRSARFVA 67
            :|||||:..::||||||.:|.||.|||:|..||:|.|.:.|||.|..|:..:|.:.|||:.:|:|
Yeast     1 MKLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIA 65

  Fly    68 RKNWILTGSDDMQIRVFNYNTLEKVHSFEAHSDYLRCIAVHPTQPLVLTSSDDMLIKLWNWEKMW 132
            |||||:.||||.:||||||||.|||..||||.||:|.||||||:|.||:.|||:.:||||||..|
Yeast    66 RKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNW 130

  Fly   133 ACQRVFEGHTHYVMQIVFNPKDNNTFASASLDRTVKVWQLGSNFANFTL-EGHEKGVNCVDYYHG 196
            |.::.||||.|:||.:.|||||.:||||..||||||||.||.:..|||| .|.|:|||.||||..
Yeast   131 ALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPL 195

  Fly   197 GDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNISAVCFHPELPIVLTGSEDGTVRIWHSGTY 261
            .||||:|:.:||..:||||||.|:||.|||||..|:|...|||.|||:::||||||::||:|.||
Yeast   196 PDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTY 260

  Fly   262 RLETCLNYGFERVWTISS-MRGTNN-VALGYDEGSIIIKVGREEPAMSMDVVGSKIIWA--KHSE 322
            ::|..||.|.||.|.|:: ..|..| :|.|:|.|..::.:|.:||.:|:|.|| |::|:  |::.
Yeast   261 KVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDPVG-KLVWSGGKNAA 324

  Fly   323 MQQVNLKTIADGTEIKDGERLPVATKDMGACEIYPQTIAHNPNGRFVVVCGDGEYIIYTSMALRN 387
            ...:....|....|::..|.|.:.||::|:.:::||::||:||||||.|.|||||:|||::|.||
Yeast   325 ASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFPQSLAHSPNGRFVTVVGDGEYVIYTALAWRN 389

  Fly   388 KAFGSAQEFVWALESNEYAIRENNGTVRLFRNFKERKSFT-PEYGA-ESIYGGYYFGVKTSSGLA 450
            ||||..|:|||..:||.||:.:..|.::.::||||..|:: |.:.| :.::.|...|||:...:.
Yeast   390 KAFGKCQDFVWGPDSNSYALIDETGQIKYYKNFKEVTSWSVPMHSAIDRLFSGALLGVKSDGFVY 454

  Fly   451 FYDWETLQLVRRIEVQPKNVFWNESGSLVCLATDDS-------YFVLGVDTAQVANAVETKEGLE 508
            |:||:...|||||:|..|:|.|:::|.||.:...:|       |.:|....|.:..|   ..|..
Yeast   455 FFDWDNGTLVRRIDVNAKDVIWSDNGELVMIVNTNSNGDEASGYTLLFNKDAYLEAA---NNGNI 516

  Fly   509 DD--GVESAFNVLGEVSECVKTGLWVGDCFIYTNSVNRINYYVGGEIVTVSHLDRTMYLLGYVPK 571
            ||  ||:.||:||.|:||.:.:|.||||.||:|.:.||:||:|||:...::|..:.||||||:.:
Yeast   517 DDSEGVDEAFDVLYELSESITSGKWVGDVFIFTTATNRLNYFVGGKTYNLAHYTKEMYLLGYLAR 581

  Fly   572 DNRIYLGDKELNVISFCLQLSVLEYQTAVMRRDFERA-DVVLPTIP-KEHRTRVAHFLEKQGFKS 634
            ||::||.|:|::|..:.:.|.|||:||..:|.:.|.| :.|||.:. |:..|::|.|||.|.:..
Yeast   582 DNKVYLADREVHVYGYEISLEVLEFQTLTLRGEIEEAIENVLPNVEGKDSLTKIARFLEGQEYYE 646

  Fly   635 QALQVSTDADHKFDLALQIGDLEIALKLARESENSQKWSQLADVASSKNNMSLVKECMQKANDLS 699
            :||.:|.|.|.||:|||::|.|.:|..|..:.....||..|.|.:..:.|..|..|....|:||.
Yeast   647 EALNISPDQDQKFELALKVGQLTLARDLLTDESAEMKWRALGDASLQRFNFKLAVEAFTNAHDLE 711

  Fly   700 GLLLLSTASGDAQLLEVVGAAGSAQGHHNLAFLSAFLRSDVERCLEILIETNRLPEAAFFARTY- 763
            .|.||.::..:.:.|..:.......|..||||.:.::..|::...::||::.|..||||...||
Yeast   712 SLFLLHSSFNNKEGLVTLAKDAERAGKFNLAFNAYWIAGDIQGAKDLLIKSQRFSEAAFLGSTYG 776

  Fly   764 -LPSQMSRIVELWREKL---GK--VNEKAGQSLADPAQYTNLFPGLGDALRVEQHLQEERARKAP 822
             ....::.||..|:|.|   ||  |:|:...:...|...::     |||    |.|.:..:..||
Yeast   777 LGDDAVNDIVTKWKENLILNGKNTVSERVCGAEGLPGSSSS-----GDA----QPLIDLDSTPAP 832

  Fly   823 ARLAANLPLNSERHPLQELFAAEQGAAGQHLEEKVKPAYVPAQAVVSSSQVAEP 876
            .:...|.....|....:|  :..:....:..||:........|.......|.||
Yeast   833 EQADENKEAEVEDSEFKE--SNSEAVEAEKKEEEAPQQQQSEQQPEQGEAVPEP 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta'COP	NP_524836.2	WD40	8..378	CDD:225201	201/374 (54%)
		WD40	8..297	CDD:238121	169/291 (58%)
		WD40 repeat	20..55	CDD:293791	16/34 (47%)
		WD40 repeat	61..97	CDD:293791	24/35 (69%)
		WD40 repeat	102..139	CDD:293791	21/36 (58%)
		WD40 repeat	146..182	CDD:293791	24/36 (67%)
		WD40 repeat	188..226	CDD:293791	23/37 (62%)
		Coatomer_WDAD	321..765	CDD:281977	176/458 (38%)
SEC27	NP_011378.1	WD40	6..293	CDD:238121	167/286 (58%)
		WD40 repeat	19..53	CDD:293791	16/33 (48%)
		WD40 repeat	59..95	CDD:293791	24/35 (69%)
		WD40 repeat	100..137	CDD:293791	21/36 (58%)
		WD40 repeat	144..180	CDD:293791	23/35 (66%)
		WD40 repeat	187..225	CDD:293791	23/37 (62%)
		WD40 repeat	231..267	CDD:293791	19/35 (54%)
		WD40 repeat	316..351	CDD:293791	7/34 (21%)
		Coatomer_WDAD	326..777	CDD:397941	176/453 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343434
Domainoid	1	1.000	336	1.000	Domainoid score	I164
eggNOG	1	0.900	-	-		E1_KOG0276
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3499
Inparanoid	1	1.050	728	1.000	Inparanoid score	I83
Isobase	1	0.950	-	0	Normalized mean entropy	S403
OMA	1	1.010	-	-		QHG53763
OrthoFinder	1	1.000	-	-		FOG0003151
OrthoInspector	1	1.000	-	-		oto99970
orthoMCL	1	0.900	-	-		OOG6_101404
Panther	1	1.100	-	-	LDO	PTHR19876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R226
SonicParanoid	1	1.000	-	-		X2116
TreeFam	1	0.960	-	-
	16	15.740