DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta'COP and COP1

DIOPT Version :9

Sequence 1:	NP_524836.2	Gene:	beta'COP / 45757	FlyBaseID:	FBgn0025724	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	NP_010136.1	Gene:	COP1 / 851410	SGDID:	S000002304	Length:	1201	Species:	Saccharomyces cerevisiae

Alignment Length:	999	Identity:	228/999 - (22%)
Similarity:	392/999 - (39%)	Gaps:	246/999 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RLTSRSDRVKCVDLHPAEPWMLCALYNGHVHIMNYENQQMVKDFEVCDVPVRSARFVARKNWILT 74
            :..|:|.|.|.:..||:.||:|.||::..:.:.:|....::..||..:.|||...|...:...::
Yeast     6 KFESKSTRAKGIAFHPSRPWVLVALFSSTIQLWDYRMGTLLHRFEDHEGPVRGLDFHPTQPIFVS 70

  Fly    75 GSDDMQIRVFNYNTLEKVHSFEAHSDYLRCIAVHPTQPLVLTSSDDMLIKLWNWE--KMWACQRV 137
            ..||..|:|::.:|.:.:::...|.||:|.:..|...|.::::|||..|::|||:  |..||
Yeast    71 AGDDYTIKVWSLDTNKCLYTLTGHLDYVRTVFFHRELPWIISASDDQTIRIWNWQNRKEIAC--- 132

  Fly   138 FEGHTHYVMQIVFNPKDNNTFASASLDRTVKVW------------------------------QL 172
            ..||.|:||...|:|.| :...|||||.|:::|                              .|
Yeast   133 LTGHNHFVMCAQFHPTD-DLIVSASLDETIRIWDISGLRKRHSAPGTSSFEEQMSAQQNLLDGSL 196

  Fly   173 GSNFANFTLEGHEKGVNCVDYYHGGDKPYLISGADDRLVKIWDYQNKTC--VQTLEGHAQNISAV 235
            |.....|.||||.:|||...::  ...|.::||:|||.||:|.......  |.|..||..|:.:|
Yeast   197 GDCVVKFILEGHTRGVNWASFH--PTLPLIVSGSDDRQVKLWRMSATKAWEVDTCRGHTNNVDSV 259

  Fly   236 CFHPELPIVLTGSEDGTVRIWHSG------TYRLETCLNYGFERVWTISSMRGTNNVALGYDEGS 294
            .|||...::::..||.|:|:|...      .::.|.      :|.|.|::....|.....:|.|.
Yeast   260 IFHPHQNLIISVGEDKTLRVWDLDKRTPVKQFKREN------DRFWLIAAHPHINLFGAAHDSGI 318

  Fly   295 IIIKVGREEPAMSMDVVGSKIIWAK-HSEMQQVNL-KTIADGTEIKDGERLPVAT-KDMGACEIY 356
            ::.|:.||.|...  :..:::.:.. ..::|..|. |.:|.         ||.|: |.:|.....
Yeast   319 MVFKLDRERPCSF--IHQNQLFFVNAEKQIQSFNFQKRVAS---------LPYASLKGIGQPWDA 372

  Fly   357 PQTIAHNP----------NGRFVVV-------------------------CGDGEYIIYTSMALR 386
            .::|::||          ||:|.:|                         .|...:::|
Yeast   373 FRSISYNPSQHSVLVNEANGKFALVILPKQPVGAVEPTSVTQDTGNFATFVGRNRFVVY------ 431

  Fly   387 NKAFGSAQEFVWALESNEYAIRENNGTVRLFRNFKERKSFTPEYGAESIYGGYYFGVKT--SSG- 448
            ||          ..||.|....||..|    ||.|..::                 |:|  ::|
Yeast   432 NK----------NTESVEVRSLENKVT----RNIKVEET-----------------VRTIVAAGP 465

  Fly   449 ----------LAFYDWETLQLVRRIEVQ-PKNVFWNESGSLVCLATDDSYFVLGVDTAQVANAV- 501
                      :..||.:..:.|.::.|: .|.|.|:..|..|.|.:..: ..|.....::.|::
Yeast   466 GSVLVIHPREVILYDVQQGKKVSQLAVKNVKYVSWSLDGQYVALMSKHT-ITLATKKLELINSMH 529

  Fly   502 ETKEGLEDDGVESAFNVLGEVSECVKTGLWVGDCFIYTNSVNRINY-YVGGEIVTVSHLDRTMYL 565
            ||..                    :|:..|.....:..:::|.|.| .:.|:...:..|::|:|:
Yeast   530 ETIR--------------------IKSAAWDETGVLIYSTLNHIRYSLLNGDRGIIKTLEKTLYI 574

  Fly   566 LGYVPKDNRIYLGDKELNVISFCLQLSVLEYQTAVMRRDFERADVVLPTIPKEHRT--RVAHFLE 628
            .....|  .:|..::|..:....:..:...::.|::.::|..   ||..|...:..  .:..:|:
Yeast   575 TKVQGK--LVYCLNREGEIEILTIDPTEYRFKKALVNKNFPE---VLRLIKDSNLVGQNIISYLQ 634

  Fly   629 KQGFKSQALQVSTDADHKFDLALQIGDLEIALKLARESENSQKWSQLADVASSKNNMSLVKECMQ 693
            |.|:...|||...|...:|||||:.|:|::||..|::..:|..|.:|...|.::.|.||.:...|
Yeast   635 KSGYPEIALQFVQDPHIRFDLALEYGNLDVALDEAKKLNDSSTWERLIQEALAQGNASLAEMIYQ 699

  Fly   694 KANDLSGLLLLSTASGDAQLLEVVGAAGSAQGHHNLAFLSAFLRSDVERCLEILIETNRLPEAAF 758
            ..:....|..|...:||...|..:......:.......|:.|..:..:....|..|...||.|..
Yeast   700 TQHSFDKLSFLYLVTGDVNKLSKMQNIAQTREDFGSMLLNTFYNNSTKERSSIFAEGGSLPLAYA 764

  Fly   759 FAR---------------------TYLPSQM-----------SRIVELWREKLGKVN--EKAGQS 789
            .|:                     ..||.||           |:.:|.|..|..:::  |||...
Yeast   765 VAKANGDEAAASAFLEQAEVDEQDVTLPDQMDASNFVQRPVISKPLEKWPLKEAELSYFEKAVLG 829

  Fly   790 LADPAQYTNLFPGLGDALRVEQHLQEERARKAPARLAANLPLNSERHPLQELFAAEQGA------ 848
            ..|.....:..|.:......|:.|.||.             .|.|.      ...::||
Yeast   830 QIDDLTIDDETPAVNTTQEQEEPLGEEN-------------FNDED------IGEDEGAWDLGDE 875

  Fly   849 ---AGQHLEEKVKPAYV--PAQAV 867
               .|:.|.|:|:...:  |||.|
Yeast   876 DLDVGEELPEEVEQGEITSPAQEV 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta'COP	NP_524836.2	WD40	8..378	CDD:225201	115/445 (26%)
		WD40	8..297	CDD:238121	94/326 (29%)
		WD40 repeat	20..55	CDD:293791	9/34 (26%)
		WD40 repeat	61..97	CDD:293791	7/35 (20%)
		WD40 repeat	102..139	CDD:293791	13/38 (34%)
		WD40 repeat	146..182	CDD:293791	14/65 (22%)
		WD40 repeat	188..226	CDD:293791	13/39 (33%)
		Coatomer_WDAD	321..765	CDD:281977	101/519 (19%)
COP1	NP_010136.1	WD40	17..322	CDD:238121	90/316 (28%)
		WD40 repeat	17..51	CDD:293791	9/33 (27%)
		WD40 repeat	59..93	CDD:293791	6/33 (18%)
		WD40 repeat	99..135	CDD:293791	13/38 (34%)
		WD40 repeat	140..206	CDD:293791	15/66 (23%)
		WD40 repeat	213..250	CDD:293791	12/38 (32%)
		WD40 repeat	256..292	CDD:293791	9/35 (26%)
		Coatomer_WDAD	343..770	CDD:397941	101/498 (20%)
		COPI_C	829..1199	CDD:399736	18/90 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910