DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta'COP and AT1G79990

DIOPT Version :9

Sequence 1:	NP_524836.2	Gene:	beta'COP / 45757	FlyBaseID:	FBgn0025724	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	NP_001154478.1	Gene:	AT1G79990 / 844339	AraportID:	AT1G79990	Length:	920	Species:	Arabidopsis thaliana

Alignment Length:	926	Identity:	483/926 - (52%)
Similarity:	656/926 - (70%)	Gaps:	50/926 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPLKLDIKRRLTSRSDRVKCVDLHPAEPWMLCALYNGHVHIMNYENQQMVKDFEVCDVPVRSARF 65
            |||:|:|||:...||:|||.|||||.|||:|.:||:|.:.|.||:.|.|||.|:|.::|||||:|
plant     1 MPLRLEIKRKFAQRSERVKSVDLHPTEPWILASLYSGTLCIWNYQTQTMVKSFDVTELPVRSAKF 65

  Fly    66 VARKNWILTGSDDMQIRVFNYNTLEKVHSFEAHSDYLRCIAVHPTQPLVLTSSDDMLIKLWNWEK 130
            :|||.|::.|:|||.|||:||||::|:..||||:||:||:|||||.|.||:||||||||||:|||
plant    66 IARKQWVVAGADDMFIRVYNYNTMDKIKVFEAHADYIRCVAVHPTLPYVLSSSDDMLIKLWDWEK 130

  Fly   131 MWACQRVFEGHTHYVMQIVFNPKDNNTFASASLDRTVKVWQLGSNFANFTLEGHEKGVNCVDYYH 195
            .|.|.::||||:|||||:.|||||.|||||||||||:|:|.|||...||||:.|.||||||||:.
plant   131 GWLCTQIFEGHSHYVMQVTFNPKDTNTFASASLDRTIKIWNLGSPDPNFTLDAHLKGVNCVDYFT 195

  Fly   196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNISAVCFHPELPIVLTGSEDGTVRIWHSGT 260
            ||||||||:|:||...|:||||.|:||||||||..|:|||.|||||||::||||||||||||:.|
plant   196 GGDKPYLITGSDDHTAKVWDYQTKSCVQTLEGHTHNVSAVSFHPELPIIITGSEDGTVRIWHATT 260

  Fly   261 YRLETCLNYGFERVWTISSMRGTNNVALGYDEGSIIIKVGREEPAMSMDVVGSKIIWAKHSEMQQ 325
            ||||..||||.||||.|..::|:..|.:|||||||::|:|||.|..|||..| |||||||:|:..
plant   261 YRLENTLNYGLERVWAIGHIKGSRRVVIGYDEGSIMVKLGREIPVASMDNSG-KIIWAKHNEIHT 324

  Fly   326 VNLKTI-ADGTEIKDGERLPVATKDMGACEIYPQTIAHNPNGRFVVVCGDGEYIIYTSMALRNKA 389
            ||:|:: ||  |:.||||||:|.|::|.|::|||::.||||||||||||||||||||::|.||::
plant   325 VNIKSVGAD--EVTDGERLPLAVKELGTCDLYPQSLKHNPNGRFVVVCGDGEYIIYTALAWRNRS 387

  Fly   390 FGSAQEFVWALESNEYAIRENNGTVRLF-RNFKERKSFTPEYGAESIYGGYYFGVKTSSGLAFYD 453
            ||||.||||: ...|:|:||::..:::| :||:|:|:..|.:.||.|:||....:.:|..:.|||
plant   388 FGSALEFVWS-SDGEHAVRESSTKIKIFSKNFQEKKTVRPTFSAEHIFGGTLLTMCSSDFICFYD 451

  Fly   454 WETLQLVRRIEVQPKNVFWNESGSLVCLATDDSYFVLGVDTAQVANAVETKEGLEDDGVESAFNV 518
            |...:|:|||:|..||::|.:||.||.:|:|.|:::|..:...|::..:..:.::::|:|.||.:
plant   452 WAECRLIRRIDVTVKNLYWADSGDLVAIASDTSFYILKFNRDIVSSYFDGGKQIDEEGIEDAFEL 516

  Fly   519 LGEVSECVKTGLWVGDCFIYTNSVNRINYYVGGEIVTVSHLDRTMYLLGYVPKDNRIYLGDKELN 583
            |.|.:|.|:||||||||||||||..|:||.||||:.|:.||||.||||||:...:|:||.|||.|
plant   517 LNETNERVRTGLWVGDCFIYTNSSWRLNYCVGGEVTTMYHLDRPMYLLGYLANQSRVYLIDKEFN 581

  Fly   584 VISFCLQLSVLEYQTAVMRRDFERADVVLPTIPKEHRTRVAHFLEKQGFKSQALQVSTDADHKFD 648
            ||.:.|.||::||:|.|||.|.|:|:.|||:|||||...||||||.:|....||:|:||.|::|:
plant   582 VIGYTLLLSLIEYKTLVMRGDLEQANEVLPSIPKEHHNSVAHFLESRGMTEDALEVATDPDYRFE 646

  Fly   649 LALQIGDLEIALKLARESENSQKWSQLADVASSKNNMSLVKECMQKANDLSGLLLLSTASGDAQL 713
            ||:|:|.|.:|..:|.|::|..||.||.::|.|...:.:.:|||:.|.||||||||.::.|||..
plant   647 LAIQLGRLAVAKDIAVEAQNESKWKQLGELAMSSGKLDMAEECMRHAMDLSGLLLLYSSLGDADG 711

  Fly   714 LEVVGAAGSAQGHHNLAFLSAFLRSDVERCLEILIETNRLPEAAFFARTYLPSQMSRIVELWREK 778
            :..:.|....||.:|:|||..|:...||.||.:|:|:||:||||..||:||||::|.||.|||..
plant   712 MMKLAALAKEQGKNNVAFLCLFMLGQVEDCLHLLVESNRIPEAALMARSYLPSKVSEIVALWRND 776

  Fly   779 LGKVNEKAGQSLADPAQYTNLFPGLGDALRVEQHLQEERARKAPARLAANLPLNSERH--PLQEL 841
            |.|::.||.:|||||.:|.|||.....||.:|....|.|....|   |.:...:::|.  .|.:.
plant   777 LTKISPKAAESLADPEEYPNLFEEWQVALSLENRAAETRGVHPP---AGDYCSHADRDHTTLVDA 838

  Fly   842 F-------------------AAEQGAAGQHLEEKVKPAYVPAQAVVSSSQVAEPTSAADDDDDLD 887
            |                   ..|:|..|:..||:                  :....:.|....:
plant   839 FRIMQIEEEGRLEQGDVLDEVGEEGEDGEEEEEE------------------DRQEESSDGRQQN 885

  Fly   888 LEIDGITLDDNIDTTD 903
            :|.:.:.:|  .|:||
plant   886 VEEEAVVVD--ADSTD 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta'COP	NP_524836.2	WD40	8..378	CDD:225201	246/370 (66%)
		WD40	8..297	CDD:238121	195/288 (68%)
		WD40 repeat	20..55	CDD:293791	20/34 (59%)
		WD40 repeat	61..97	CDD:293791	21/35 (60%)
		WD40 repeat	102..139	CDD:293791	25/36 (69%)
		WD40 repeat	146..182	CDD:293791	26/35 (74%)
		WD40 repeat	188..226	CDD:293791	27/37 (73%)
		Coatomer_WDAD	321..765	CDD:281977	224/445 (50%)
AT1G79990	NP_001154478.1	WD40	17..297	CDD:238121	191/279 (68%)
		WD40 repeat	19..55	CDD:293791	21/35 (60%)
		WD40	24..473	CDD:225201	280/452 (62%)
		WD40 repeat	62..97	CDD:293791	20/34 (59%)
		WD40 repeat	103..140	CDD:293791	26/36 (72%)
		WD40 repeat	145..182	CDD:293791	27/36 (75%)
		WD40 repeat	189..226	CDD:293791	26/36 (72%)
		WD40 repeat	232..264	CDD:293791	25/31 (81%)
		Coatomer_WDAD	320..763	CDD:281977	224/445 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	472	1.000	Domainoid score	I89
eggNOG	1	0.900	-	-		E1_KOG0276
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3499
Inparanoid	1	1.050	1005	1.000	Inparanoid score	I41
OMA	1	1.010	-	-		QHG53763
OrthoDB	1	1.010	-	-		D139008at2759
OrthoFinder	1	1.000	-	-		FOG0003151
OrthoInspector	1	1.000	-	-		otm2762
orthoMCL	1	0.900	-	-		OOG6_101404
Panther	1	1.100	-	-	LDO	PTHR19876
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840