DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta'COP and AT1G52360

DIOPT Version :9

Sequence 1:	NP_524836.2	Gene:	beta'COP / 45757	FlyBaseID:	FBgn0025724	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	NP_001185203.1	Gene:	AT1G52360 / 841666	AraportID:	AT1G52360	Length:	970	Species:	Arabidopsis thaliana

Alignment Length:	935	Identity:	486/935 - (51%)
Similarity:	654/935 - (69%)	Gaps:	49/935 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PLKLDIKRRLTSRSDRVKCVDLHPAEPWMLCALYNGHVHIMNYENQQMVKDFEVCDVPVRSARFV 66
            ||:|:|||:|..||:|||.|||||.|||:|.:||:|.:.|.||:.|.|.|.|||.::|||||:||
plant    46 PLRLEIKRKLAQRSERVKSVDLHPTEPWILASLYSGTLCIWNYQTQVMAKSFEVTELPVRSAKFV 110

  Fly    67 ARKNWILTGSDDMQIRVFNYNTLEKVHSFEAHSDYLRCIAVHPTQPLVLTSSDDMLIKLWNWEKM 131
            |||.|::.|:|||.|||:||||::||..|||||||:||:|||||.|.||:||||||||||:|||.
plant   111 ARKQWVVAGADDMYIRVYNYNTMDKVKVFEAHSDYIRCVAVHPTLPYVLSSSDDMLIKLWDWEKG 175

  Fly   132 WACQRVFEGHTHYVMQIVFNPKDNNTFASASLDRTVKVWQLGSNFANFTLEGHEKGVNCVDYYHG 196
            |||.::||||:|||||:.|||||.|||||||||||:|:|.|||...||||:.|:||||||||:.|
plant   176 WACTQIFEGHSHYVMQVTFNPKDTNTFASASLDRTIKIWNLGSPDPNFTLDAHQKGVNCVDYFTG 240

  Fly   197 GDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNISAVCFHPELPIVLTGSEDGTVRIWHSGTY 261
            |||||||:|:||...|:||||.|:||||||||..|:|||||||||||::||||||||||||:.||
plant   241 GDKPYLITGSDDHTAKVWDYQTKSCVQTLEGHTHNVSAVCFHPELPIIITGSEDGTVRIWHATTY 305

  Fly   262 RLETCLNYGFERVWTISSMRGTNNVALGYDEGSIIIKVGREEPAMSMDVVGSKIIWAKHSEMQQV 326
            |||..||||.||||.|..::.:..|.:|||||:|::|:|||.|..|||..| |||||||:|:|..
plant   306 RLENTLNYGLERVWAIGYIKSSRRVVIGYDEGTIMVKLGREIPVASMDNTG-KIIWAKHNEIQTA 369

  Fly   327 NLKTIADGTEIKDGERLPVATKDMGACEIYPQTIAHNPNGRFVVVCGDGEYIIYTSMALRNKAFG 391
            |:|:|....|:.||||||::.|::|.|::|||::.||||||||||||||||||||::|.||::||
plant   370 NIKSIGADYEVTDGERLPLSVKELGTCDLYPQSLKHNPNGRFVVVCGDGEYIIYTALAWRNRSFG 434

  Fly   392 SAQEFVWALESNEYAIRENNGTVRLF-RNFKERKSFTPEYGAESIYGGYYFGVKTSSGLAFYDWE 455
            |..||||:.| .|.|:||::..:::| :||:|::|..|.:.||.|:||....:.:|..:.||||.
plant   435 SGLEFVWSSE-GECAVRESSSKIKIFSKNFQEKRSIRPTFSAEKIFGGTLLAMCSSDFICFYDWA 498

  Fly   456 TLQLVRRIEVQPKNVFWNESGSLVCLATDDSYFVLGVDTAQVANAVETKEGLEDDGVESAFNVLG 520
            ..:|::||:|..||::|.:||.||.:|:|.|:::|..:...|.:..::....|::|||.||.||.
plant   499 ECRLIQRIDVTVKNLYWADSGDLVAIASDTSFYILKFNRDLVTSHFDSGRPTEEEGVEDAFEVLH 563

  Fly   521 EVSECVKTGLWVGDCFIYTNSVNRINYYVGGEIVTVSHLDRTMYLLGYVPKDNRIYLGDKELNVI 585
            |..|.|:||:||||||||.||..::||.||||:.|:.||||.||||||:...:|::|.|||.|||
plant   564 ENDERVRTGIWVGDCFIYNNSSWKLNYCVGGEVTTMYHLDRPMYLLGYLASQSRVFLVDKEFNVI 628

  Fly   586 SFCLQLSVLEYQTAVMRRDFERADVVLPTIPKEHRTRVAHFLEKQGFKSQALQVSTDADHKFDLA 650
            .:.|.||::||:|.|||.|.::|..:||||||:....||||||.:|....||:::||.|::|:||
plant   629 GYTLLLSLIEYKTLVMRGDLDKASEILPTIPKDQHNSVAHFLESRGMIEDALEIATDPDYRFELA 693

  Fly   651 LQIGDLEIALKLARESENSQKWSQLADVASSKNNMSLVKECMQKANDLSGLLLLSTASGDAQLLE 715
            :|:|.||||.::|.|.::..||.||.::|.|...:.:.:|||:.|.||||||||.::.|||:.:.
plant   694 IQLGRLEIAQEIAVEVQSESKWKQLGELAMSSGKLQMAEECMKYAMDLSGLLLLYSSLGDAEGVT 758

  Fly   716 VVGAAGSAQGHHNLAFLSAFLRSDVERCLEILIETNRLPEAAFFARTYLPSQMSRIVELWREKLG 780
            .:......||.:|:|||..|:...:|.||::|:|:||:||||..||:||||::|.||.|||:.|.
plant   759 KLATLAKEQGKNNVAFLCLFMLGKLEDCLQLLVESNRIPEAALMARSYLPSKVSEIVALWRKDLS 823

  Fly   781 KVNEKAGQSLADPAQYTNLFPGLGDALRVEQHLQEER------------ARKAPARLA---ANLP 830
            |||.||.:|||||.:|:|||.....||.||....|.|            |.|:...|.   .||.
plant   824 KVNSKAAESLADPEEYSNLFEDWQVALSVEAKAVETRGVYTGAKDYPSHADKSSMTLVEAFRNLQ 888

  Fly   831 LNSER--------HPLQELFAAEQG-------AAGQHLEEKVKPAYVPAQAVVSSSQVAEPTSAA 880
            :..|.        |  :|:.|.|.|       ...:|:||.            ...:.||.....
plant   889 VEEEESLENGDMDH--EEVVAEENGNEQRNEDDVAEHVEEH------------HEEKEAEEEEGI 939

  Fly   881 DDDDDLD--LEIDGITLDDNIDTTD 903
            .|.|..|  :.::|...|:...|.:
plant   940 VDGDSTDGAVLVNGSEADEEWGTNN 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta'COP	NP_524836.2	WD40	8..378	CDD:225201	248/369 (67%)
		WD40	8..297	CDD:238121	199/288 (69%)
		WD40 repeat	20..55	CDD:293791	19/34 (56%)
		WD40 repeat	61..97	CDD:293791	23/35 (66%)
		WD40 repeat	102..139	CDD:293791	26/36 (72%)
		WD40 repeat	146..182	CDD:293791	26/35 (74%)
		WD40 repeat	188..226	CDD:293791	27/37 (73%)
		Coatomer_WDAD	321..765	CDD:281977	215/444 (48%)
AT1G52360	NP_001185203.1	WD40	41..518	CDD:225201	295/473 (62%)
		WD40	61..341	CDD:238121	194/279 (70%)
		WD40 repeat	63..99	CDD:293791	20/35 (57%)
		WD40 repeat	147..184	CDD:293791	27/36 (75%)
		WD40 repeat	189..226	CDD:293791	27/36 (75%)
		WD40 repeat	233..270	CDD:293791	26/36 (72%)
		WD40 repeat	276..308	CDD:293791	26/31 (84%)
		Coatomer_WDAD	364..808	CDD:281977	215/444 (48%)
		WD40 repeat	400..433	CDD:293791	25/32 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	472	1.000	Domainoid score	I89
eggNOG	1	0.900	-	-		E1_KOG0276
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3499
Inparanoid	1	1.050	1005	1.000	Inparanoid score	I41
OMA	1	1.010	-	-		QHG53763
OrthoDB	1	1.010	-	-		D139008at2759
OrthoFinder	1	1.000	-	-		FOG0003151
OrthoInspector	1	1.000	-	-		otm2762
orthoMCL	1	0.900	-	-		OOG6_101404
Panther	1	1.100	-	-	LDO	PTHR19876
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2116
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840