DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta'COP and AT3G15980

DIOPT Version :9

Sequence 1:	NP_524836.2	Gene:	beta'COP / 45757	FlyBaseID:	FBgn0025724	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	NP_001189908.1	Gene:	AT3G15980 / 820842	AraportID:	AT3G15980	Length:	930	Species:	Arabidopsis thaliana

Alignment Length:	925	Identity:	481/925 - (52%)
Similarity:	648/925 - (70%)	Gaps:	41/925 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPLKLDIKRRLTSRSDRVKCVDLHPAEPWMLCALYNGHVHIMNYENQQMVKDFEVCDVPVRSARF 65
            |||:|||||:...||:|||.|||||.|||:|.:||:|.|.|.||:.|.:.|.|||.::|||||:|
plant     1 MPLRLDIKRKFAQRSERVKSVDLHPTEPWILASLYSGTVCIWNYQTQTITKSFEVTELPVRSAKF 65

  Fly    66 VARKNWILTGSDDMQIRVFNYNTLEKVHSFEAHSDYLRCIAVHPTQPLVLTSSDDMLIKLWNWEK 130
            :.||.|::.|:|||.|||:||||::||..|||||||:||:|||||.|.||:||||||||||:||.
plant    66 IPRKQWVVAGADDMYIRVYNYNTMDKVKVFEAHSDYIRCVAVHPTLPYVLSSSDDMLIKLWDWEN 130

  Fly   131 MWACQRVFEGHTHYVMQIVFNPKDNNTFASASLDRTVKVWQLGSNFANFTLEGHEKGVNCVDYYH 195
            .|||.::||||:|||||:||||||.|||||||||||:|:|.|||...||||:.|:||||||||:.
plant   131 GWACTQIFEGHSHYVMQVVFNPKDTNTFASASLDRTIKIWNLGSPDPNFTLDAHQKGVNCVDYFT 195

  Fly   196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNISAVCFHPELPIVLTGSEDGTVRIWHSGT 260
            ||||||||:|:||...|:||||.|:|||||:||..|:|||||||||||::||||||||||||:.|
plant   196 GGDKPYLITGSDDHTAKVWDYQTKSCVQTLDGHTHNVSAVCFHPELPIIITGSEDGTVRIWHATT 260

  Fly   261 YRLETCLNYGFERVWTISSMRGTNNVALGYDEGSIIIKVGREEPAMSMDVVGSKIIWAKHSEMQQ 325
            ||||..||||.||||.|..::.:..|.:|||||:|::|:|||.|..|||..| |||||||:|:|.
plant   261 YRLENTLNYGLERVWAIGYIKSSRRVVIGYDEGTIMVKLGREIPVASMDSSG-KIIWAKHNEIQT 324

  Fly   326 VNLKTIADGTEI----------KDGERLPVATKDMGACEIY------PQTIAHNPNGRFVVVCGD 374
            .|:|:|..|.|:          ||   .|...|..|.. |:      .|::.|||||||||||||
plant   325 ANIKSIGAGYELSSLYLRLLMEKD---FPCLLKSWGPV-IFIHNYSNSQSLKHNPNGRFVVVCGD 385

  Fly   375 GEYIIYTSMALRNKAFGSAQEFVWALESNEYAIRENNGTVRLF-RNFKERKSFTPEYGAESIYGG 438
            |||||||::|.||::|||..||||:.| .|.|:||::..:::| :||:||||..|.:.||.|:||
plant   386 GEYIIYTALAWRNRSFGSGLEFVWSSE-GECAVRESSSKIKIFSKNFQERKSIRPTFSAEKIFGG 449

  Fly   439 YYFGVKTSSGLAFYDWETLQLVRRIEVQPKNVFWNESGSLVCLATDDSYFVLGVDTAQVANAVET 503
            ....:.::..:.||||...:|:::|:|..||::|.|||.||.:|:|.|:::|..:...|::..::
plant   450 TLLAMCSNDFICFYDWAECRLIQQIDVTVKNLYWAESGDLVAIASDTSFYILKYNRELVSSHFDS 514

  Fly   504 KEGLEDDGVESAFNVLGEVSECVKTGLWVGDCFIYTNSVNRINYYVGGEIVTVSHLDRTMYLLGY 568
            ....:::|||.||.||.|..|.|:||:||||||||.||..::||.||||:.|:.||||.||||||
plant   515 GRPTDEEGVEDAFEVLHENDERVRTGIWVGDCFIYNNSSWKLNYCVGGEVTTMYHLDRPMYLLGY 579

  Fly   569 VPKDNRIYLGDKELNVISFCLQLSVLEYQTAVMRRDFERADVVLPTIPKEHRTRVAHFLEKQGFK 633
            :...:|:||.|||.|||.:.|.||::||:|.|||.|.:||:.:|||||||....||||||.:|..
plant   580 IANQSRVYLVDKEFNVIGYTLLLSLIEYKTLVMRGDLDRANQILPTIPKEQHNNVAHFLESRGMI 644

  Fly   634 SQALQVSTDADHKFDLALQIGDLEIALKLARESENSQKWSQLADVASSKNNMSLVKECMQKANDL 698
            ..||:::||.|:|||||:|:|.||||.::|.|.::..||.||.::|.|...:.|.::||:.|.||
plant   645 EDALEIATDPDYKFDLAIQLGRLEIAKEIAEEVQSESKWKQLGELAMSSGKLQLAEDCMKYAMDL 709

  Fly   699 SGLLLLSTASGDAQLLEVVGAAGSAQGHHNLAFLSAFLRSDVERCLEILIETNRLPEAAFFARTY 763
            ||||||.::.|||:.:..:......||.:|:|||..|....:|.||::|:|:||:||||..||:|
plant   710 SGLLLLYSSLGDAEGVSKLACLAKEQGKNNVAFLCLFTLGRLEDCLQLLVESNRIPEAALMARSY 774

  Fly   764 LPSQMSRIVELWREKLGKVNEKAGQSLADPAQYTNLFPGLGDALRVEQHLQEERARKAPARLAAN 828
            |||::|.||.||||.|.|||.||.:|||||.:|:|||.....||.||.:..|.|.....|.   |
plant   775 LPSKVSEIVALWREDLSKVNPKAAESLADPEEYSNLFEDWQVALSVEANTAETRGVYTAAE---N 836

  Fly   829 LPLNSERH--PLQELFAAEQGAAGQHLEEKVKPAYVPAQAVVSSSQVAEPTSAADDDDDLDLEI- 890
            .|.::::.  .|.|.|...|..|    ||.::...:..:....:..|   .:..|:::..:.|:
plant   837 YPSHADKPSITLVEAFRNLQVEA----EESLENGNIDHEVAEENGHV---ENEGDEEEQQEEEVN 894

  Fly   891 --DGITLDDNIDTTD 903
              :|:.   :.|:||
plant   895 EEEGVV---DADSTD 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta'COP	NP_524836.2	WD40	8..378	CDD:225201	240/385 (62%)
		WD40	8..297	CDD:238121	195/288 (68%)
		WD40 repeat	20..55	CDD:293791	19/34 (56%)
		WD40 repeat	61..97	CDD:293791	21/35 (60%)
		WD40 repeat	102..139	CDD:293791	25/36 (69%)
		WD40 repeat	146..182	CDD:293791	27/35 (77%)
		WD40 repeat	188..226	CDD:293791	27/37 (73%)
		Coatomer_WDAD	321..765	CDD:281977	216/460 (47%)
AT3G15980	NP_001189908.1	WD40	17..297	CDD:238121	191/279 (68%)
		WD40 repeat	20..55	CDD:293791	19/34 (56%)
		WD40	24..447	CDD:225201	260/428 (61%)
		WD40 repeat	62..97	CDD:293791	20/34 (59%)
		WD40 repeat	103..140	CDD:293791	26/36 (72%)
		WD40 repeat	145..182	CDD:293791	28/36 (78%)
		WD40 repeat	189..226	CDD:293791	26/36 (72%)
		WD40 repeat	232..264	CDD:293791	26/31 (84%)
		Coatomer_WDAD	320..776	CDD:281977	216/460 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	472	1.000	Domainoid score	I89
eggNOG	1	0.900	-	-		E1_KOG0276
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3499
Inparanoid	1	1.050	1005	1.000	Inparanoid score	I41
OMA	1	1.010	-	-		QHG53763
OrthoDB	1	1.010	-	-		D139008at2759
OrthoFinder	1	1.000	-	-		FOG0003151
OrthoInspector	1	1.000	-	-		otm2762
orthoMCL	1	0.900	-	-		OOG6_101404
Panther	1	1.100	-	-	O	PTHR19876
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2116
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840