DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta'COP and AT2G21390

DIOPT Version :9

Sequence 1:	NP_524836.2	Gene:	beta'COP / 45757	FlyBaseID:	FBgn0025724	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	NP_179734.1	Gene:	AT2G21390 / 816678	AraportID:	AT2G21390	Length:	1218	Species:	Arabidopsis thaliana

Alignment Length:	996	Identity:	244/996 - (24%)
Similarity:	426/996 - (42%)	Gaps:	224/996 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RLTSRSDRVKCVDLHPAEPWMLCALYNGHVHIMNYENQQMVKDFEVCDVPVRSARFVARKNWILT 74
            :..::|:|||.:..||..||:|.:|::|.:.:.:|....::..|:..:.|||...|...:...::
plant     4 KFETKSNRVKGLSFHPKRPWILASLHSGVIQLWDYRMGTLIDRFDEHEGPVRGVHFHNSQPLFVS 68

  Fly    75 GSDDMQIRVFNYNTLEKVHSFEAHSDYLRCIAVHPTQPLVLTSSDDMLIKLWNWEKMWACQRVFE 139
            |.||.:|:|:||.|...:.:...|.||:|.:..|...|.::::|||..|::|||:.. .|..|..
plant    69 GGDDYKIKVWNYKTHRCLFTLLGHLDYIRTVQFHHENPWIVSASDDQTIRIWNWQSR-TCISVLT 132

  Fly   140 GHTHYVMQIVFNPKDNNTFASASLDRTVKVWQLGS---------------------------NFA 177
            ||.||||...|:||: :...|||||:||:||.:|:                           ...
plant   133 GHNHYVMCASFHPKE-DLVVSASLDQTVRVWDIGALKKKSASPADDLMRFSQMNSDLFGGVDAIV 196

  Fly   178 NFTLEGHEKGVNCVDYYHGGDKPYLISGADDRLVKIWDYQNKTC---VQTLEGHAQNISAVCFHP 239
            .:.||||::|||...::  ...|.::||||||.||:| ..|:|.   |.||.||..|:|:|.||.
plant   197 KYVLEGHDRGVNWASFH--PTLPLIVSGADDRQVKLW-RMNETKAWEVDTLRGHMNNVSSVMFHA 258

  Fly   240 ELPIVLTGSEDGTVRIWHS------GTYRLETCLNYGFERVWTISSMRGTNNVALGYDEGSIIIK 298
            :..|:::.|||.::|:|.:      .|:|.|      .:|.|.::.....|.:|.|:|.|.|:.|
plant   259 KQDIIVSNSEDKSIRVWDATKRTGIQTFRRE------HDRFWILAVHPEINLLAAGHDNGMIVFK 317

  Fly   299 VGREEPAMSMDVVGSKIIWAKHSEMQQVNLKTIADGTEIKDGERLPVATKDMGACEIYPQTIAHN 363
            :.||.||.::.  |..:.:||...::.....|      .||.:.:|:......:....|:|::::
plant   318 LERERPAFALS--GDSLFYAKDRFLRYYEYST------QKDSQVIPIRRPGTPSLNQSPRTLSYS 374

  Fly   364 PNGRFVVVCGD---GEYIIY--------TSMALRNKAFGSAQEFVWALESNEYAIRENNGTVRLF 417
            |....|::|.|   |.|.:|        .|..:::...|:....|: :..|.:|:.|.:.:..|.
plant   375 PTENAVLICSDLDGGSYELYIIPKDSVGRSDVVQDAKRGTGGSAVF-IARNRFAVLEKSTSQVLV 438

  Fly   418 RNFKERKSFTPEYGAESIYGGYYFGVKTSSGLAFYDWETLQLVRRIEVQPKNVFWNESGSLVCLA 482
            :|.|...                  ||.||               :.:....:|:..:|:|:|.:
plant   439 KNLKNEV------------------VKKSS---------------LPIPTDAIFYAGTGNLLCRS 470

  Fly   483 TD-------DSYFVLGVDTAQVANAVETKEGLEDDGVESAFNVL----GEVSEC-------VKTG 529
            .|       ....|||.........|.....:|...:.|...::    ..|.:|       ||:|
plant   471 EDKVVIFDLQQRLVLGELQTPFVRYVVWSNDMESVALLSKHTIIIASKKLVLQCTLHETIRVKSG 535

  Fly   530 LWVGD-CFIYTNSVNRINYYV-GGEIVTVSHLDRTMYLLGYVPKDNRIYLGDKELNVISFCLQ-- 590
            .|..: .|||| ::|.|.|.: .|:...:..||        ||    ||:.....|.| |||.
plant   536 AWDDNGVFIYT-TLNHIKYCLPNGDSGIIRTLD--------VP----IYITKVSGNTI-FCLDRD 586

  Fly   591 -------LSVLEY--QTAVMRRDFERADVVLPTIPKEHRTRVAHFLEKQGFKSQALQVSTDADHK 646
                   ::..||  :.|::|:.::....::.......:..:| :|:::||...||....|...:
plant   587 GKNRAITINATEYIFKLALLRKKYDHVMSMIKNSQLCGQAMIA-YLQQKGFPEVALHFVEDERIR 650

  Fly   647 FDLALQIGDLEIALKLARESENSQKWSQLADVASSKNNMSLVKECMQKANDLSGLLLLSTASGD- 710
            |:|||:.|::.:|:..|.|......|.:|...|..:.|..:|:...|:..:...|..|...:|:
plant   651 FNLALESGNISVAVASATEINEKDHWYRLGVEALRQGNSRIVEFAYQQTKNFERLSFLYLITGNL 715

  Fly   711 ---AQLLEVVGAAGSAQGH-HNLAFLSAFLRSDVERCLEILIETNRLPEAAFFARTYLPSQMSRI 771
               ::|:::.....:..|. ||..:|     .||:..::||.....||.|      |:.:.:..:
plant   716 DKLSKLMKIAEVKNNVMGQFHNALYL-----GDVKERVKILENAGHLPLA------YITASVHGL 769

  Fly   772 VELWREKLGKVNEKAGQSLADPAQYTNLFPGLGDALRVEQHLQEERARKAPARL--------AAN 828
            .:        :.|:....|.|..      |.|.:.             |.|:.|        ..:
plant   770 TD--------IAERLAIELGDNV------PSLPEG-------------KTPSLLMPPSPIMCGGD 807

  Fly   829 LPLNSERHPLQE--LFAAEQGAAGQHLEEKVKPAY--------------VPAQAVVSSSQVAEPT 877
            .||......:.|  |.:|.:||..:. ||.|:..:              ...:|::..::..|
plant   808 WPLLRVMKGIFEGGLESANRGAVDEE-EEDVEGDWGEGLDKFDVDGMENTDIEAILDGAEAGE-- 869

  Fly   878 SAADDDD-----DLDL--EID 891
             ..||::     ||||  |:|
plant   870 -EEDDEEGGWGLDLDLPPELD 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta'COP	NP_524836.2	WD40	8..378	CDD:225201	124/406 (31%)
		WD40	8..297	CDD:238121	105/322 (33%)
		WD40 repeat	20..55	CDD:293791	9/34 (26%)
		WD40 repeat	61..97	CDD:293791	10/35 (29%)
		WD40 repeat	102..139	CDD:293791	12/36 (33%)
		WD40 repeat	146..182	CDD:293791	14/62 (23%)
		WD40 repeat	188..226	CDD:293791	16/40 (40%)
		Coatomer_WDAD	321..765	CDD:281977	103/490 (21%)
AT2G21390	NP_179734.1	WD40	9..317	CDD:238121	105/318 (33%)
		WD40 repeat	15..49	CDD:293791	9/33 (27%)
		WD40 repeat	55..91	CDD:293791	10/35 (29%)
		WD40 repeat	96..132	CDD:293791	12/36 (33%)
		WD40 repeat	139..201	CDD:293791	14/62 (23%)
		WD40 repeat	207..245	CDD:293791	16/40 (40%)
		WD40 repeat	251..288	CDD:293791	11/36 (31%)
		WD40 repeat	295..316	CDD:293791	6/20 (30%)
		Coatomer_WDAD	337..769	CDD:397941	103/497 (21%)
		COPI_C	816..1212	CDD:399736	18/78 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139008at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920