DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta'COP and Copb2

DIOPT Version :9

Sequence 1:	NP_524836.2	Gene:	beta'COP / 45757	FlyBaseID:	FBgn0025724	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	NP_068533.2	Gene:	Copb2 / 60384	RGDID:	628746	Length:	905	Species:	Rattus norvegicus

Alignment Length:	916	Identity:	626/916 - (68%)
Similarity:	757/916 - (82%)	Gaps:	14/916 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPLKLDIKRRLTSRSDRVKCVDLHPAEPWMLCALYNGHVHIMNYENQQMVKDFEVCDVPVRSARF 65
            |||:|||||:||:||||||.|||||.|||||.:||||.|.:.|:|.|.:||.|||||:|||:|:|
  Rat     1 MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKF 65

  Fly    66 VARKNWILTGSDDMQIRVFNYNTLEKVHSFEAHSDYLRCIAVHPTQPLVLTSSDDMLIKLWNWEK 130
            ||||||::||:||||||||||||||:||.|||||||:||||||||||.:||||||||||||:|:|
  Rat    66 VARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDK 130

  Fly   131 MWACQRVFEGHTHYVMQIVFNPKDNNTFASASLDRTVKVWQLGSNFANFTLEGHEKGVNCVDYYH 195
            .|:|.:|||||||||||||.||||||.|||||||||:|||||||:..|||||||||||||:|||.
  Rat   131 KWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYS 195

  Fly   196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNISAVCFHPELPIVLTGSEDGTVRIWHSGT 260
            ||||||||||||||||||||||||||||||||||||:|...|||||||::|||||||||||||.|
  Rat   196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSST 260

  Fly   261 YRLETCLNYGFERVWTISSMRGTNNVALGYDEGSIIIKVGREEPAMSMDVVGSKIIWAKHSEMQQ 325
            ||||:.||||.||||.::|:||:|||||||||||||:|:||||||||||..| |||||||||:||
  Rat   261 YRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANG-KIIWAKHSEVQQ 324

  Fly   326 VNLKTIADGTEIKDGERLPVATKDMGACEIYPQTIAHNPNGRFVVVCGDGEYIIYTSMALRNKAF 390
            .|||.:.| ||||||||||:|.||||:||||||||.||||||||||||||||||||:||||||:|
  Rat   325 ANLKAMGD-TEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSF 388

  Fly   391 GSAQEFVWALESNEYAIRENNGTVRLFRNFKERKSFTPEYGAESIYGGYYFGVKTSSGLAFYDWE 455
            ||||||.||.:|:||||||:|..|::|:||||:|||.|::||||||||:..||::.:||||||||
  Rat   389 GSAQEFAWAHDSSEYAIRESNSVVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSVNGLAFYDWE 453

  Fly   456 TLQLVRRIEVQPKNVFWNESGSLVCLATDDSYFVLGVDTAQVANAVETKEGLEDDGVESAFNVLG 520
            ..:|:||||:|||::||::||.|||:||::|:|:|...:.:|..|.||.||:.:||:|.||.|||
  Rat   454 NTELIRRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQETHEGVTEDGIEDAFEVLG 518

  Fly   521 EVSECVKTGLWVGDCFIYTNSVNRINYYVGGEIVTVSHLDRTMYLLGYVPKDNRIYLGDKELNVI 585
            |:.|.||||||||||||||:||||:||||||||||::|||||||||||:|||||:||||||||::
  Rat   519 EIQEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIV 583

  Fly   586 SFCLQLSVLEYQTAVMRRDFERADVVLPTIPKEHRTRVAHFLEKQGFKSQALQVSTDADHKFDLA 650
            |:.|.:||||||||||||||..||.||||||||.||||||||||||||.|||.||||.:|:|:||
  Rat   584 SYSLLVSVLEYQTAVMRRDFSMADKVLPTIPKEQRTRVAHFLEKQGFKQQALTVSTDPEHRFELA 648

  Fly   651 LQIGDLEIALKLARESENSQKWSQLADVASSKNNMSLVKECMQKANDLSGLLLLSTASGDAQLLE 715
            ||:|:|:||.:||.|:|:.|||.|||::|.||...||.:||:..|.|..|||||:||||:|.::.
  Rat   649 LQLGELKIAYQLAVEAESEQKWKQLAELAISKCQFSLAQECLHHAQDYGGLLLLATASGNASMVN 713

  Fly   716 VVGAAGSAQGHHNLAFLSAFLRSDVERCLEILIETNRLPEAAFFARTYLPSQMSRIVELWREKLG 780
            .:.......|.:|:||:|.||:..::.|||:||.|.|||||||.||||||||:||:|:||||.|.
  Rat   714 KLAEGAERDGKNNVAFMSYFLQGKLDACLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLS 778

  Fly   781 KVNEKAGQSLADPAQYTNLFPGLGDALRVEQHLQEERARKAPARLAANLPLNSERHPLQELFAAE 845
            |||:||.:|||||.:|.||||||.:|..||:.::|..|...||:....:..|.||:.::|....:
  Rat   779 KVNQKAAESLADPTEYENLFPGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEAKGFQ 843

  Fly   846 QGAAGQHLEEKVKPAYVPAQAVVSSSQVA--EPTSAADDDDDLD-LEIDGITLDDNIDTTDVNLD 907
            ...|....|...|||..|   |:.:||..  |..|..:.:|||| :|:      ::|||||:|||
  Rat   844 PSRATAQQEPDGKPASSP---VIMASQTTHKEEKSFQELEDDLDTMEL------EDIDTTDINLD 899

  Fly   908 DDFLSD 913
            :|.|.|
  Rat   900 EDILDD 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta'COP	NP_524836.2	WD40	8..378	CDD:225201	299/369 (81%)
		WD40	8..297	CDD:238121	233/288 (81%)
		WD40 repeat	20..55	CDD:293791	21/34 (62%)
		WD40 repeat	61..97	CDD:293791	28/35 (80%)
		WD40 repeat	102..139	CDD:293791	27/36 (75%)
		WD40 repeat	146..182	CDD:293791	29/35 (83%)
		WD40 repeat	188..226	CDD:293791	35/37 (95%)
		Coatomer_WDAD	321..765	CDD:281977	300/443 (68%)
Copb2	NP_068533.2	WD40	8..297	CDD:238121	233/288 (81%)
		WD 1	13..52		25/38 (66%)
		WD40 repeat	19..55	CDD:293791	22/35 (63%)
		WD 2	55..94		31/38 (82%)
		WD 3	97..136		31/38 (82%)
		WD40 repeat	103..140	CDD:293791	28/36 (78%)
		WD 4	140..180		33/39 (85%)
		WD40 repeat	145..182	CDD:293791	30/36 (83%)
		WD 5	183..224		38/40 (95%)
		WD40 repeat	189..226	CDD:293791	34/36 (94%)
		WD 6	227..266		31/38 (82%)
		WD40 repeat	232..268	CDD:293791	26/35 (74%)
		Coatomer_WDAD	319..763	CDD:397941	301/444 (68%)
		WD 7	350..388		34/37 (92%)
		WD 8	390..425		23/34 (68%)
		WD 9	746..783		28/36 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..905		27/76 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	638	1.000	Domainoid score	I159
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3499
Inparanoid	1	1.050	1292	1.000	Inparanoid score	I147
OMA	1	1.010	-	-		QHG53763
OrthoDB	1	1.010	-	-		D122926at33208
OrthoFinder	1	1.000	-	-		FOG0003151
OrthoInspector	1	1.000	-	-		oto97899
orthoMCL	1	0.900	-	-		OOG6_101404
Panther	1	1.100	-	-	O	PTHR19876
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2116
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980