DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta'COP and sec27

DIOPT Version :9

Sequence 1:	NP_524836.2	Gene:	beta'COP / 45757	FlyBaseID:	FBgn0025724	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	NP_001342707.1	Gene:	sec27 / 2540050	PomBaseID:	SPBC16C6.13c	Length:	796	Species:	Schizosaccharomyces pombe

Alignment Length:	791	Identity:	348/791 - (43%)
Similarity:	523/791 - (66%)	Gaps:	2/791 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LKLDIKRRLTSRSDRVKCVDLHPAEPWMLCALYNGHVHIMNYENQQMVKDFEVCDVPVRSARFVA 67
            ::||.:|:|.|.::|||.||.||.|||::.:.|||.|.|.||..|.:|:.|::.|||:|:..|:|
pombe     2 MRLDFQRKLLSHTERVKAVDFHPTEPWVIASHYNGQVGIWNYNTQTLVRSFDINDVPIRACAFIA 66

  Fly    68 RKNWILTGSDDMQIRVFNYNTLEKVHSFEAHSDYLRCIAVHPTQPLVLTSSDDMLIKLWNWEKMW 132
            ||||.:.||||.|:||:||||.|||..||||.||:|.:.||||||.:|||||||.||.:||:..|
pombe    67 RKNWFVCGSDDFQVRVYNYNTGEKVTQFEAHPDYIRALVVHPTQPFLLTSSDDMTIKCFNWDMSW 131

  Fly   133 ACQRVFEGHTHYVMQIVFNPKDNNTFASASLDRTVKVWQLGSNFANFTLEGHEKGVNCVDYYHGG 197
            .|.:.||||:.|||.:..||||.|||||:.||.|||||..||:.|||||:.|::|||.|:||..|
pombe   132 KCVQTFEGHSRYVMSLAINPKDTNTFASSCLDGTVKVWSFGSSVANFTLQAHDRGVNYVNYYPAG 196

  Fly   198 DKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNISAVCFHPELPIVLTGSEDGTVRIWHSGTYR 262
            ||||||:..||.|:|:||||.|.||:.||||..|:|...||.:.||:::|||||||:|||:.:|.
pombe   197 DKPYLITAGDDNLIKVWDYQTKACVRILEGHTNNVSFAFFHSKFPIIISGSEDGTVKIWHTLSYS 261

  Fly   263 LETCLNYGFERVWTISSMRGTNNVALGYDEGSIIIKVGREEPAMSMDVVGSKIIWAKHSEMQQVN 327
            |....|:..:|.|.|:..:....|.:|:|.|.|...:||:||:::||..| |::|:.::|:....
pombe   262 LIKSYNFSLDRAWCIAQNKDNGLVTVGFDNGLITFSLGRDEPSVTMDSSG-KVVWSNYNEVMSAM 325

  Fly   328 LKTIADGTEIKDGERLPVATKDMGACEIYPQTIAHNPNGRFVVVCGDGEYIIYTSMALRNKAFGS 392
            ::...:.:::.||..:.::.|::|..|:||..:.|:||||||.|||:||||:||::|.||||:|.
pombe   326 IRPAKEQSDLTDGSLISLSVKELGTTELYPAVLKHSPNGRFVSVCGNGEYIVYTALAWRNKAYGK 390

  Fly   393 AQEFVWALESNEYAIRENNGTVRLFRNFKERKSFTPEYGAESIYGGYYFGVKTSSGLAFYDWETL 457
            |.:|.|:.:||.|..|.::.::.:.:||||.......|..:.|:||:..||..|..:.||||:|.
pombe   391 ALDFAWSADSNVYGSRTSDRSIVIHKNFKESNRLDLSYSCDKIFGGFLLGVVGSDFICFYDWDTG 455

  Fly   458 QLVRRIEVQPKNVFWNESGSLVCLATDDSYFVLGVDTAQVANAVETKEGLEDDGVESAFNVLGEV 522
            .|||:|:|:||.|:||:.|..|.||.||.:::||.:.....:|||:....|::||..:|..|.:|
pombe   456 ILVRKIDVKPKGVYWNDDGRFVILACDDDFYLLGFNAEMFYSAVESGTADEEEGVADSFEALADV 520

  Fly   523 SECVKTGLWVGDCFIYTNSVNRINYYVGGEIVTVSHLDRTMYLLGYVPKDNRIYLGDKELNVISF 587
            ||.|..|.||.:.||||.:..|:||.:|.:...:::::.:.|||||:|:|:||||.|:::||:|:
pombe   521 SESVVNGKWVAETFIYTTTAARLNYLIGDQTYKIANVESSFYLLGYIPRDDRIYLTDRDMNVVSY 585

  Fly   588 CLQLSVLEYQTAVMRRDFERADVVLPTIPKEHRTRVAHFLEKQGFKSQALQVSTDADHKFDLALQ 652
            ...|:::|||:.|::.|.|.|..:|..|.:..|.|::.||.:.|:|..||::|.|:..:|:|||.
pombe   586 SFNLAIIEYQSLVLKGDLEAAQGLLEQISETDRPRLSDFLSRLGYKEAALELSGDSVQRFELALD 650

  Fly   653 IGDLEIALKLARESENSQKWSQLADVASSKNNMSLVKECMQKANDLSGLLLLSTASGDAQLLEVV 717
            ...|:||.::|:|.::..||..|.|.|.:..:..|.:||.:|..|...|:||.||:.:.:.|:.:
pombe   651 AQRLDIASQIAQELDDPLKWRSLGDAALNAWDFVLAQECFEKGKDYGSLVLLYTATNNHEGLKEL 715

  Fly   718 GAAGSAQGHHNLAFLSAFLRSDVERCLEILIETNRLPEAAFFARTYLPSQMSRIVELWREKLGK- 781
            .....:...:|.||:.::|.:....|:.||..|.|.|||..||.||.|.::..::..|:..|.|
pombe   716 SQLTKSTKINNTAFICSWLTNQPAECVNILTSTQRYPEANLFAATYCPDEVKNVLPEWKVDLTKN 780

  Fly   782 VNEKAGQSLAD 792
            ..|:...||.|
pombe   781 QKERIADSLGD 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta'COP	NP_524836.2	WD40	8..378	CDD:225201	188/369 (51%)
		WD40	8..297	CDD:238121	159/288 (55%)
		WD40 repeat	20..55	CDD:293791	17/34 (50%)
		WD40 repeat	61..97	CDD:293791	22/35 (63%)
		WD40 repeat	102..139	CDD:293791	20/36 (56%)
		WD40 repeat	146..182	CDD:293791	23/35 (66%)
		WD40 repeat	188..226	CDD:293791	23/37 (62%)
		Coatomer_WDAD	321..765	CDD:281977	170/443 (38%)
sec27	NP_001342707.1	WD40	8..297	CDD:238121	159/288 (55%)
		WD40 repeat	18..54	CDD:293791	18/35 (51%)
		WD40 repeat	59..95	CDD:293791	21/35 (60%)
		WD40 repeat	102..138	CDD:293791	20/35 (57%)
		WD40 repeat	144..181	CDD:293791	24/36 (67%)
		WD40 repeat	187..225	CDD:293791	23/37 (62%)
		WD40 repeat	231..255	CDD:293791	12/23 (52%)
		WD40 repeat	313..344	CDD:293791	4/30 (13%)
		Coatomer_WDAD	319..763	CDD:309255	170/443 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	363	1.000	Domainoid score	I150
eggNOG	1	0.900	-	-		E1_KOG0276
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3499
Inparanoid	1	1.050	758	1.000	Inparanoid score	I81
OMA	1	1.010	-	-		QHG53763
OrthoFinder	1	1.000	-	-		FOG0003151
OrthoInspector	1	1.000	-	-		oto101685
orthoMCL	1	0.900	-	-		OOG6_101404
Panther	1	1.100	-	-	LDO	PTHR19876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R226
SonicParanoid	1	1.000	-	-		X2116
TreeFam	1	0.960	-	-
	14	13.860