DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment beta'COP and Y41C4A.32

DIOPT Version :9

Sequence 1:	NP_524836.2	Gene:	beta'COP / 45757	FlyBaseID:	FBgn0025724	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	NP_499518.2	Gene:	Y41C4A.32 / 189814	WormBaseID:	WBGene00270321	Length:	291	Species:	Caenorhabditis elegans

Alignment Length:	288	Identity:	127/288 - (44%)
Similarity:	196/288 - (68%)	Gaps:	7/288 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SRSDRVKCVDLHPAEPWMLCALYNGHVHIMNYENQQMVKDFEVCDVPVRSARFVARKNWILTGSD 77
            |.|||||.||.|..:||:|.||:.|:|.|.||:.:.:||..||.:...|:|:|:.|||||.|.||
Worm    10 SHSDRVKSVDFHSEKPWILTALHTGNVQIWNYDTKTLVKAMEVSEKSTRAAKFIHRKNWIATASD 74

  Fly    78 DMQIRVFNYNTLEKVHSFEAHSDYLRCIAVHPTQPLVLTSSDDMLIKLWNWEKMWACQRVFEGHT 142
            |.|||:|:..|...::.|.||||::|.:.||||.|.::::|||..|::|:||..|..::.|:.|.
Worm    75 DQQIRIFDAETFSLINEFTAHSDFIRSLTVHPTLPYLISASDDRKIRVWDWENEWRMEQEFQEHA 139

  Fly   143 HYVMQIVFNPKDNNTFASASLDRTVKVWQLGSNFANFTLEGHEKGVNCVDYYHGGDKPYLISGAD 207
            ||:|||..||:|...|.|.|||:|:|||:||...:..||||||||||||::..||   .::||:|
Worm   140 HYIMQIAVNPEDPEMFVSGSLDKTLKVWKLGEQESICTLEGHEKGVNCVEFLTGG---RIVSGSD 201

  Fly   208 DRLVKIWDYQNKTCVQTLE-GHAQNISAVCFHPELPIVLTGSEDGTVRIWHSGTYRLETCLNYGF 271
            |..:.:||.|.:.|::||: .|..|::.|.  |....:::|:||.||:||:|.|:.||..||:..
Worm   202 DCSICVWDIQTQKCIETLKNAHKNNVTFVT--PFKTWIISGAEDSTVKIWNSQTFSLEKELNFEK 264

  Fly   272 ERVWTISSMRGTNNVALGYDEGSIIIKV 299
            .|.|.:::.: ::.:|:|:|.|::.:::
Worm   265 GRAWCVAAGK-SDAIAVGFDSGAVTVEI 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta'COP	NP_524836.2	WD40	8..378	CDD:225201	127/288 (44%)
		WD40	8..297	CDD:238121	127/284 (45%)
		WD40 repeat	20..55	CDD:293791	15/34 (44%)
		WD40 repeat	61..97	CDD:293791	18/35 (51%)
		WD40 repeat	102..139	CDD:293791	14/36 (39%)
		WD40 repeat	146..182	CDD:293791	18/35 (51%)
		WD40 repeat	188..226	CDD:293791	15/37 (41%)
		Coatomer_WDAD	321..765	CDD:281977
Y41C4A.32	NP_499518.2	WD40	8..271	CDD:238121	123/265 (46%)
		WD40 repeat	17..52	CDD:293791	15/34 (44%)
		WD40 repeat	58..94	CDD:293791	18/35 (51%)
		WD40 repeat	99..136	CDD:293791	14/36 (39%)
		WD40 repeat	143..179	CDD:293791	18/35 (51%)
		WD40 repeat	185..220	CDD:293791	15/37 (41%)
		WD40 repeat	224..251	CDD:293791	10/28 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122926at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19876
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020