DRSC/TRiP Functional Genomics Resources

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Protein Alignment beta'COP and E03H4.8

DIOPT Version :10

Sequence 1:NP_524836.2 Gene:beta'COP / 45757 FlyBaseID:FBgn0025724 Length:914 Species:Drosophila melanogaster
Sequence 2:NP_493151.1 Gene:E03H4.8 / 184023 WormBaseID:WBGene00008476 Length:368 Species:Caenorhabditis elegans


Alignment Length:356 Identity:153/356 - (42%)
Similarity:224/356 - (62%) Gaps:43/356 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   297 IKVGREEPAMSMDVVGSKIIWAKHSEMQQVNLKTIADGTEIKDGERLPVATKDMGACEIYPQTIA 361
            :::..|.||:|||..| :|:||..||:|.|.|:::.:..|..|||||.::.|::|:.||.|||:|
 Worm     5 VQLSIENPAVSMDSTG-QILWAVQSEIQAVYLRSLFEQKEANDGERLTLSVKNLGSSEISPQTLA 68

  Fly   362 HNPNGRFVVVCGDGEYIIYT-----SMALRNKAFGSAQEFVWALESNEYAIRENNGTVRLFRNFK 421
            |:.||.|.:.||||:||:||     ::||:.:.:|...|||||...|.:|:||:...|::.:|||
 Worm    69 HSSNGHFFMACGDGKYIVYTYKQYDAIALKIRHYGQGLEFVWAAHPNMFAVRESATNVKIKKNFK 133

  Fly   422 ERKSFTPEYGAESIYGGYYFGVKTSSGLAFYDWETLQLVRRIEVQPKNVFWNESGSLVCLATDDS 486
            :.||...:...|.|.||....::::..|.|:|||:..||||||:..|:|:|:::..:|.:..|||
 Worm   134 DHKSIRSDMMLEGISGGPLLALRSNDSLCFFDWESAALVRRIEITSKSVYWSDNREMVAICGDDS 198

  Fly   487 YFVLGVDTAQVANAVETKEGLEDDGVESAFNVLGEVSECVKTGLWVGDCFIYTN--SVNRINYYV 549
            ::|.......||||.|..|    ||:|.||.|:||.:|.|:||.|:|||||:|.  ::||||:|.
 Worm   199 FYVFKYSAEAVANATEVTE----DGIEDAFKVIGEQAEAVETGFWIGDCFIFTTALTINRINHYA 259

  Fly   550 GGEIVTVSHLDRTMYLLGYVPKDNRIYLGDKELNVISFCLQLSVLEYQTAVMRRD---------- 604
            |||||||:|:||.:.||||:.:|:|:|..||:|||||:.|..|.||||||.||||          
 Worm   260 GGEIVTVAHVDRPLCLLGYMAEDSRVYAVDKDLNVISYELFQSDLEYQTATMRRDIGTRGGPQIC 324

  Fly   605 -------------------FERADVVLPTIP 616
                               |::.|  ||.:|
 Worm   325 RICRLPSSANLPNLPSTANFKKVD--LPNLP 353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta'COPNP_524836.2 WD40 8..297 CDD:238121 153/356 (43%)
WD40 repeat 20..55 CDD:293791
WD40 repeat 61..97 CDD:293791
WD40 repeat 102..139 CDD:293791
WD40 repeat 146..182 CDD:293791
WD40 repeat 188..226 CDD:293791
Coatomer_WDAD_beta-like 304..779 CDD:438572 152/349 (44%)
WD40 repeat 304..349 CDD:438572 20/44 (45%)
WD40 repeat 355..389 CDD:438572 19/38 (50%)
WD40 repeat 395..427 CDD:438572 15/31 (48%)
WD40 repeat 433..464 CDD:438572 13/30 (43%)
WD40 repeat 468..521 CDD:438572 20/52 (38%)
WD40 repeat 525..564 CDD:438572 25/40 (63%)
WD40 repeat 565..589 CDD:438572 14/23 (61%)
E03H4.8NP_493151.1 Coatomer_WDAD 12..>317 CDD:451663 147/309 (48%)
WD40 repeat 12..56 CDD:438571 20/44 (45%)
WD40 repeat 62..101 CDD:438571 19/38 (50%)
WD40 repeat 107..130 CDD:438571 10/22 (45%)
WD40 repeat 147..176 CDD:438571 12/28 (43%)
WD40 repeat 180..229 CDD:438571 20/52 (38%)
WD40 repeat 233..274 CDD:438571 25/40 (63%)
WD40 repeat 275..299 CDD:438571 14/23 (61%)
Blue background indicates that the domain is not in the aligned region.

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