DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta'COP and copb-2

DIOPT Version :9

Sequence 1:	NP_524836.2	Gene:	beta'COP / 45757	FlyBaseID:	FBgn0025724	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	NP_501671.1	Gene:	copb-2 / 177779	WormBaseID:	WBGene00009542	Length:	1000	Species:	Caenorhabditis elegans

Alignment Length:	927	Identity:	531/927 - (57%)
Similarity:	686/927 - (74%)	Gaps:	44/927 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPLKLDIKRRLTSRSDRVKCVDLHPAEPWMLCALYNGHVHIMNYENQQMVKDFEVCDVPVRSARF 65
            |||:||:||:|.:||||||||||||.|.|:|.|||||:|||.|||.|.:||.|||||||||:|:|
Worm     1 MPLRLDVKRKLLARSDRVKCVDLHPVETWLLAALYNGNVHIWNYETQTLVKSFEVCDVPVRAAKF 65

  Fly    66 VARKNWILTGSDDMQIRVFNYNTLEKVHSFEAHSDYLRCIAVHPTQPLVLTSSDDMLIKLWNWEK 130
            |.||:|::||||||.||||||||||:||.|||||||||.:.||||.|.|::||||||:|:|:|:.
Worm    66 VPRKSWVVTGSDDMHIRVFNYNTLERVHQFEAHSDYLRSLVVHPTLPYVISSSDDMLVKMWDWDN 130

  Fly   131 MWACQRVFEGHTHYVMQIVFNPKDNNTFASASLDRTVKVWQLGSNFANFTLEGHEKGVNCVDYYH 195
            .||.::.|||||||||||..|||||||||:||||:||||||.|||..||||||||||||||||||
Worm   131 KWAMKQSFEGHTHYVMQIAINPKDNNTFATASLDKTVKVWQFGSNVPNFTLEGHEKGVNCVDYYH 195

  Fly   196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNISAVCFHPELPIVLTGSEDGTVRIWHSGT 260
            ||:|||:||||||.||||||||||||||||:|||||:|:||||||||:::|||||.|||:||:.|
Worm   196 GGEKPYIISGADDHLVKIWDYQNKTCVQTLDGHAQNVSSVCFHPELPLIITGSEDSTVRLWHANT 260

  Fly   261 YRLETCLNYGFERVWTISSMRGTNNVALGYDEGSIIIKVGREEPAMSMDVVGSKIIWAKHSEMQQ 325
            |||||.||||.||||.|.:.:|.|.:|:||||||:.:|:||||||:|||..| ||:||||||:||
Worm   261 YRLETTLNYGLERVWCIQAQKGANTIAIGYDEGSVTLKLGREEPAVSMDSSG-KILWAKHSEIQQ 324

  Fly   326 VNLKTIA--DGTEIKDGERLPVATKDMGACEIYPQTIAHNPNGRFVVVCGDGEYIIYTSMALRNK 388
            .|||||:  :...|:||||||::.||:|:.||||||:||:.||||||.|||||||:||:||||||
Worm   325 ANLKTISTEESEAIQDGERLPLSVKDLGSSEIYPQTLAHSSNGRFVVACGDGEYIVYTAMALRNK 389

  Fly   389 AFGSAQEFVWALESNEYAIRENNGTVRLFRNFKERKSFTPEYGAESIYGGYYFGVKTSSGLAFYD 453
            .||...|||||::.|.:|:||:...|::.:|||:.||...:...|.|.||....:::::.|.|:|
Worm   390 DFGQGLEFVWAVDPNMFAVRESATNVKIKKNFKDHKSIRSDMVLEGISGGPLLALRSNNSLCFFD 454

  Fly   454 WETLQLVRRIEVQPKNVFWNESGSLVCLATDDSYFVLGVDTAQVANAVETKEGLEDDGVESAFNV 518
            ||:..||||||:..|:::|:::|.:|.:..|||::||......||||.|..|    ||:|.||.|
Worm   455 WESAVLVRRIEITSKSIYWSDNGEMVAICGDDSFYVLKYSAEAVANATEVTE----DGIEDAFEV 515

  Fly   519 LGEVSECVKTGLWVGDCFIYTNSVNRINYYVGGEIVTVSHLDRTMYLLGYVPKDNRIYLGDKELN 583
            :||.:|.||||.|:|||||:|.::|||||||||||||::|:||.:|||||:.|::|:|..||:||
Worm   516 IGEQAEAVKTGFWIGDCFIFTTALNRINYYVGGEIVTIAHVDRPLYLLGYMAKESRVYAVDKDLN 580

  Fly   584 VISFCLQLSVLEYQTAVMRRDFERADVVLPTIPKEHRTRVAHFLEKQGFKSQALQVSTDADHKFD 648
            |||:.|.|||||||||||||||:.||.||.|||||.||||||||||||||.|||.||.|.|||||
Worm   581 VISYKLLLSVLEYQTAVMRRDFDTADKVLTTIPKEQRTRVAHFLEKQGFKKQALAVSQDPDHKFD 645

  Fly   649 LALQIGDLEIALKLARESENSQKWSQLADVASSKNNMSLVKECMQKANDLSGLLLLSTASGDAQL 713
            |::.:|||:.|..||.:|::.:||..|::.|:.|:.:.|..||:.:|.|..||:||:|.:|.|.|
Worm   646 LSVALGDLKTAYDLALQSDSEEKWKALSNAATLKSELLLAGECLGRARDFGGLMLLATCAGSAPL 710

  Fly   714 LEVVGAAGSAQGHHNLAFLSAFLRSDVERCLEILIETNRLPEAAFFARTYLPSQMSRIVELWREK 778
            |:.:....:|...||::|||:.|..|::.||:.||.|.|||||||.|||:.||::|.|:|||:.|
Worm   711 LQKLADDSAAAESHNISFLSSLLLGDIDACLDKLISTGRLPEAAFLARTHAPSRVSSILELWKAK 775

  Fly   779 LG----KVNEKAGQSLADPAQYTNLFPGLGDALRVEQHLQEERARKAPARLAANLPLNSERHPLQ 839
            ..    |.:.|.|:|||||.:|.|||||...:|:.|..::|  ..|.|...:..:|..:.|:..:
Worm   776 ASGHSEKSSRKIGESLADPVKYENLFPGFTQSLKAESFVRE--ISKIPVPASVRVPSAATRNIQE 838

  Fly   840 EL-FAAEQGA-------------AGQHLEEKVKPAYVPAQA-----VVSSSQVAEPTSAAD---- 881
            || .|...||             |.:..|.::|....|:.|     |...|.:.||:...:
Worm   839 ELDEAVASGAVSFTDDGQAVLKNAPRQTETQLKAPPPPSVARQPSPVRQPSPIREPSPIREPEPE 903

  Fly   882 --------DDDDLDLEI 890
                    |||..::.:
Worm   904 EEEEQEEFDDDQQEVHV 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta'COP	NP_524836.2	WD40	8..378	CDD:225201	272/371 (73%)
		WD40	8..297	CDD:238121	217/288 (75%)
		WD40 repeat	20..55	CDD:293791	24/34 (71%)
		WD40 repeat	61..97	CDD:293791	26/35 (74%)
		WD40 repeat	102..139	CDD:293791	19/36 (53%)
		WD40 repeat	146..182	CDD:293791	28/35 (80%)
		WD40 repeat	188..226	CDD:293791	34/37 (92%)
		Coatomer_WDAD	321..765	CDD:281977	246/445 (55%)
copb-2	NP_501671.1	WD40	<8..297	CDD:225201	217/288 (75%)
		WD40	15..295	CDD:238121	212/279 (76%)
		WD40 repeat	19..55	CDD:293791	25/35 (71%)
		WD40 repeat	62..97	CDD:293791	25/34 (74%)
		WD40 repeat	103..140	CDD:293791	19/36 (53%)
		WD40 repeat	145..182	CDD:293791	29/36 (81%)
		WD40 repeat	189..226	CDD:293791	33/36 (92%)
		WD40 repeat	232..268	CDD:293791	25/35 (71%)
		Coatomer_WDAD	320..762	CDD:281977	246/445 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158765
Domainoid	1	1.000	512	1.000	Domainoid score	I158
eggNOG	1	0.900	-	-		E1_KOG0276
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3499
Inparanoid	1	1.050	1091	1.000	Inparanoid score	I123
Isobase	1	0.950	-	0	Normalized mean entropy	S403
OMA	1	1.010	-	-		QHG53763
OrthoDB	1	1.010	-	-		D122926at33208
OrthoFinder	1	1.000	-	-		FOG0003151
OrthoInspector	1	1.000	-	-		oto20350
orthoMCL	1	0.900	-	-		OOG6_101404
Panther	1	1.100	-	-	LDO	PTHR19876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R226
SonicParanoid	1	1.000	-	-		X2116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750