DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta'COP and COPA

DIOPT Version :9

Sequence 1:	NP_524836.2	Gene:	beta'COP / 45757	FlyBaseID:	FBgn0025724	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	NP_001091868.1	Gene:	COPA / 1314	HGNCID:	2230	Length:	1233	Species:	Homo sapiens

Alignment Length:	985	Identity:	246/985 - (24%)
Similarity:	420/985 - (42%)	Gaps:	192/985 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RLTSRSDRVKCVDLHPAEPWMLCALYNGHVHIMNYENQQMVKDFEVCDVPVRSARFVARKNWILT 74
            :..::|.|||.:..||..||:|.:|:||.:.:.:|....::..|:..|.|||...|..::...::
Human     4 KFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVS 68

  Fly    75 GSDDMQIRVFNYNTLEKVHSFEAHSDYLRCIAVHPTQPLVLTSSDDMLIKLWNWEKMWACQRVFE 139
            |.||.:|:|:||.....:.:...|.||:|....|...|.:|::|||..|::|||:.. .|..|..
Human    69 GGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSR-TCVCVLT 132

  Fly   140 GHTHYVMQIVFNPKDNNTFASASLDRTVKVWQLG-------------SNFANFT----------- 180
            ||.||||...|:|.: :...|||||:||:||.:.             |:....|
Human   133 GHNHYVMCAQFHPTE-DLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAV 196

  Fly   181 ----LEGHEKGVNCVDYYHGGDKPYLISGADDRLVKIWDYQNKTC--VQTLEGHAQNISAVCFHP 239
                ||||::|||...::  ...|.::||||||.||||.......  |.|..||..|:|...|||
Human   197 VKHVLEGHDRGVNWAAFH--PTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHP 259

  Fly   240 ELPIVLTGSEDGTVRIWHSG------TYRLETCLNYGFERVWTISSMRGTNNVALGYDEGSIIIK 298
            ...::|:.|||.::|:|...      |:|.:      .:|.|.:::....|..|.|:|.|.|:.|
Human   260 RQELILSNSEDKSIRVWDMSKRTGVQTFRRD------HDRFWVLAAHPNLNLFAAGHDGGMIVFK 318

  Fly   299 VGREEPAMSMDVVGSKIIWAKHSEMQQVNLKTIADGT--EIKDGERLPVATKDMGACEIYPQTIA 361
            :.||.||.:  |.|:.:.:.|...::|::..:..|..  :::.|.:.||.            .::
Human   319 LERERPAYA--VHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVF------------NMS 369

  Fly   362 HNPNGRFVVVC------GDGEYIIYTSMALRNKAFGSAQE--------FVWALESNEYAIRENNG 412
            :||....|::|      .:..|.:||.....:.....|.|        .|| :..|.:|:.:...
Human   370 YNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVW-VARNRFAVLDRMH 433

  Fly   413 TVRLFRNFKE---RKSFTPEYGAESIYGGYYFG-----VKTSSGLAFYDWETLQLVRRIEV-QPK 468
            :: |.:|.|.   :|...|  ..:.|   :|.|     ::.:..:..:|.:..:.:..::: :.|
Human   434 SL-LIKNLKNEITKKVQVP--NCDEI---FYAGTGNLLLRDADSITLFDVQQKRTLASVKISKVK 492

  Fly   469 NVFWNESGSLVC-LATDDSYFVLGVDTAQVANAVETKEGLEDDGVESAFNVLGEVSECVKTGLW- 531
            .|.|:...|.|. ||..:....|.:....:.|.          .:::..|:...:.  ||:|.|
Human   493 YVIWSADMSHVALLAKHEHSCPLPLTAIVICNR----------KLDALCNIHENIR--VKSGAWD 545

  Fly   532 VGDCFIYTNSVNRINYYVGGEIVTVSH-LDRTMYLLGYVP--KDNRIYLGDKELNVISFCLQLSV 593
            ....||||.| |.|.|    .:.|..| :.||:.|..||.  |.|.:|..|:|.......:..:.
Human   546 ESGVFIYTTS-NHIKY----AVTTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLTIDPTE 605

  Fly   594 LEYQTAVMRRDFERADVVLPTIPKEHRTR--------VAHFLEKQGFKSQALQVSTDADHKFDLA 650
            .:::.|::.|.:   |.||      |..|        :..:|:|:|:...||....|...:|.||
Human   606 FKFKLALINRKY---DEVL------HMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLA 661

  Fly   651 LQIGDLEIALKLARESENSQKWSQLADVASSKNNMSLVKECMQKANDLSGLLLLSTASGDAQ--- 712
            |:.|::||||:.|:..::...|.:|.:||..:.|..:|:.|.|:..:...|..|...:|:.:
Human   662 LECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLR 726

  Fly   713 -LLEVVGAAGSAQGHHNLAFLSAFLRSDVERCLEILIETNRLPEAAFFARTY-LPSQMSRIVELW 775
             ::::........||:.    :|....||...:.||....:...|...|.|: |..:...:.|.:
Human   727 KMMKIAEIRKDMSGHYQ----NALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEAESLKETF 787

  Fly   776 REKLGKVNEKAGQSLADPAQYTNLFPGLGDALRVEQHLQEERARKAPA---RLAANLPLNSERHP 837
                            ||.:.|  .|.:....::.|         .||   .|..|.||.:....
Human   788 ----------------DPEKET--IPDIDPNAKLLQ---------PPAPIMPLDTNWPLLTVSKG 825

  Fly   838 LQELFAAEQGAAGQHLEEKVKPAYVPAQAVVSSSQV-AEPTSAADDDDDLDLEIDGITLDDNIDT 901
            ..|...|.:|..|               |:.:...: ...|....:|.:|.|:.||.     ::.
Human   826 FFEGTIASKGKGG---------------ALAADIDIDTVGTEGWGEDAELQLDEDGF-----VEA 870

  Fly   902 TDVNLDDDFL 911
            |: .|.||.|
Human   871 TE-GLGDDAL 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta'COP	NP_524836.2	WD40	8..378	CDD:225201	121/411 (29%)
		WD40	8..297	CDD:238121	104/322 (32%)
		WD40 repeat	20..55	CDD:293791	10/34 (29%)
		WD40 repeat	61..97	CDD:293791	9/35 (26%)
		WD40 repeat	102..139	CDD:293791	13/36 (36%)
		WD40 repeat	146..182	CDD:293791	14/63 (22%)
		WD40 repeat	188..226	CDD:293791	15/39 (38%)
		Coatomer_WDAD	321..765	CDD:281977	105/486 (22%)
COPA	NP_001091868.1	proxenin	1..35		12/30 (40%)
		WD40	<2..317	CDD:225201	104/322 (32%)
		WD 1	3..38		12/33 (36%)
		WD40	9..318	CDD:238121	104/318 (33%)
		WD40 repeat	15..49	CDD:293791	10/33 (30%)
		WD 2	42..80		11/37 (30%)
		WD40 repeat	55..91	CDD:293791	9/35 (26%)
		WD 3	84..122		12/37 (32%)
		WD40 repeat	96..132	CDD:293791	13/36 (36%)
		WD 4	126..164		19/38 (50%)
		WD40 repeat	139..202	CDD:293791	14/63 (22%)
		WD 5	195..234		18/40 (45%)
		WD40 repeat	208..241	CDD:293791	13/34 (38%)
		WD 6	241..278		15/36 (42%)
		WD40 repeat	249..278	CDD:293791	11/28 (39%)
		WD 7	282..319		10/42 (24%)
		Coatomer_WDAD	339..776	CDD:281977	105/485 (22%)
		WD40 repeat	365..406	CDD:293791	8/52 (15%)
		COPI_C	825..1227	CDD:284395	16/76 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122926at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920