DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta'COP and copb2

DIOPT Version :9

Sequence 1:	NP_524836.2	Gene:	beta'COP / 45757	FlyBaseID:	FBgn0025724	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	NP_001001940.1	Gene:	copb2 / 114454	ZFINID:	ZDB-GENE-010724-7	Length:	934	Species:	Danio rerio

Alignment Length:	939	Identity:	626/939 - (66%)
Similarity:	767/939 - (81%)	Gaps:	31/939 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPLKLDIKRRLTSRSDRVKCVDLHPAEPWMLCALYNGHVHIMNYENQQMVKDFEVCDVPVRSARF 65
            |||:|||||:||:||||||.|||||:|||||.:||||.|.:.|:|.|.:||.|||||:|||:::|
Zfish     1 MPLRLDIKRKLTARSDRVKSVDLHPSEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRASKF 65

  Fly    66 VARKNWILTGSDDMQIRVFNYNTLEKVHSFEAHSDYLRCIAVHPTQPLVLTSSDDMLIKLWNWEK 130
            ||||||::||:||||||||||||||:||.|||||||:||||||||||.:||||||||||||:|||
Zfish    66 VARKNWVITGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPYILTSSDDMLIKLWDWEK 130

  Fly   131 MWACQRVFEGHTHYVMQIVFNPKDNNTFASASLDRTVKVWQLGSNFANFTLEGHEKGVNCVDYYH 195
            .|:|.:|||||||||||||.||||||.|||||||||:|||||||:..|||||||:|||||:|||.
Zfish   131 KWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHDKGVNCIDYYS 195

  Fly   196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNISAVCFHPELPIVLTGSEDGTVRIWHSGT 260
            ||||||||||||||||||||||||||||||||||||:|.|.|||||||::|||||||||||||.|
Zfish   196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCVNFHPELPIIITGSEDGTVRIWHSST 260

  Fly   261 YRLETCLNYGFERVWTISSMRGTNNVALGYDEGSIIIKVGREEPAMSMDVVGSKIIWAKHSEMQQ 325
            ||||:.||||.||||.:|.:||:|:|||||||||||||:||||||||||..| |||||||||:||
Zfish   261 YRLESTLNYGMERVWCVSGLRGSNSVALGYDEGSIIIKLGREEPAMSMDTNG-KIIWAKHSEIQQ 324

  Fly   326 VNLKTIADGTEIKDGERLPVATKDMGACEIYPQTIAHNPNGRFVVVCGDGEYIIYTSMALRNKAF 390
            .|||.:.| .|||||||||:|.||||:||||||||.||||||||||||||||||||:||||||:|
Zfish   325 ANLKAMGD-AEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSF 388

  Fly   391 GSAQEFVWALESNEYAIRENNGTVRLFRNFKERKSFTPEYGAESIYGGYYFGVKTSSGLAFYDWE 455
            |||||||||.:|:||||||::..|::|:||||:|||.|::|||.||||:..||::.:||||||||
Zfish   389 GSAQEFVWAHDSSEYAIRESSSVVKIFKNFKEKKSFKPDFGAEGIYGGFLLGVRSVNGLAFYDWE 453

  Fly   456 TLQLVRRIEVQPKNVFWNESGSLVCLATDDSYFVLGVDTAQVANAVETKEGLEDDGVESAFNVLG 520
            ..:|:||||:|||::||::||.|||:||::|:|:|...:.:||.:.|..||:.:||:|.||.|||
Zfish   454 NTELIRRIEIQPKHIFWSDSGELVCIATEESFFILRYLSEKVAASQENNEGVTEDGIEDAFEVLG 518

  Fly   521 EVSECVKTGLWVGDCFIYTNSVNRINYYVGGEIVTVSHLDRTMYLLGYVPKDNRIYLGDKELNVI 585
            |:.|.||||||||||||||:||||:||:|||||||::|||||||||||:|||:|:||||||||::
Zfish   519 EIQEVVKTGLWVGDCFIYTSSVNRLNYFVGGEIVTIAHLDRTMYLLGYIPKDDRLYLGDKELNIV 583

  Fly   586 SFCLQLSVLEYQTAVMRRDFERADVVLPTIPKEHRTRVAHFLEKQGFKSQALQVSTDADHKFDLA 650
            |:.|.:||||||||||||||..||.||||||||.||||||||||||||.|||.||||.:|:|:||
Zfish   584 SYSLLVSVLEYQTAVMRRDFGMADKVLPTIPKEQRTRVAHFLEKQGFKQQALAVSTDPEHRFELA 648

  Fly   651 LQIGDLEIALKLARESENSQKWSQLADVASSKNNMSLVKECMQKANDLSGLLLLSTASGDAQLLE 715
            ||:|:|:||.:||.|:|:.|||.|||::|.||....|.:||:..|.|..|||||:||||:|.::.
Zfish   649 LQLGELKIAYQLAVEAESEQKWKQLAELAISKCQFGLAQECLHHAQDYGGLLLLATASGNASMVA 713

  Fly   716 VVGAAGSAQGHHNLAFLSAFLRSDVERCLEILIETNRLPEAAFFARTYLPSQMSRIVELWREKLG 780
            .:.......|.:|:||::.||:..::.|||:||:|||||||||.||||||||:||:|:||||.|.
Zfish   714 KLAEGAERDGKNNVAFMTYFLQGKLDNCLELLIKTNRLPEAAFLARTYLPSQVSRVVKLWRESLS 778

  Fly   781 KVNEKAGQSLADPAQYTNLFPGLGDALRVEQHLQEERARKAPARLAANLPL---NSERHPLQELF 842
            |||:||.:|||||.:|.||||||.:|...||:|:|  ......|.|::.||   |.||:.|:|..
Zfish   779 KVNQKAAESLADPTEYENLFPGLREAFVAEQYLKE--TSLGQTRPASDYPLITPNEERNVLEEAS 841

  Fly   843 AAEQGA---AGQHLEEKVKP-----AYVPAQAVVSSSQ------VAEPT-------SAADDD--D 884
            ..|...   |...|:::|..     |.|.:.:.|||:|      :.|.|       :||:..  |
Zfish   842 GYEPKGILPAPTQLKQEVSEDEEVLASVSSVSAVSSAQSQPDPKLQEKTEEKTPEITAAEQKVID 906

  Fly   885 DLDLEIDGITLDDNIDTTDVNLDDDFLSD 913
            :|:.::|.:..|| ||||||||||.::.|
Zfish   907 ELEDDLDNMEFDD-IDTTDVNLDDGYVDD 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta'COP	NP_524836.2	WD40	8..378	CDD:225201	298/369 (81%)
		WD40	8..297	CDD:238121	232/288 (81%)
		WD40 repeat	20..55	CDD:293791	21/34 (62%)
		WD40 repeat	61..97	CDD:293791	27/35 (77%)
		WD40 repeat	102..139	CDD:293791	28/36 (78%)
		WD40 repeat	146..182	CDD:293791	29/35 (83%)
		WD40 repeat	188..226	CDD:293791	35/37 (95%)
		Coatomer_WDAD	321..765	CDD:281977	294/443 (66%)
copb2	NP_001001940.1	WD40	8..297	CDD:238121	232/288 (81%)
		WD40 repeat	19..55	CDD:293791	22/35 (63%)
		WD40	24..428	CDD:225201	323/405 (80%)
		WD40 repeat	103..140	CDD:293791	29/36 (81%)
		WD40 repeat	145..182	CDD:293791	30/36 (83%)
		WD40 repeat	189..226	CDD:293791	34/36 (94%)
		WD40 repeat	232..262	CDD:293791	23/29 (79%)
		Coatomer_WDAD	320..763	CDD:281977	294/443 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	629	1.000	Domainoid score	I169
eggNOG	1	0.900	-	-		E1_KOG0276
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3499
Inparanoid	1	1.050	1274	1.000	Inparanoid score	I163
OMA	1	1.010	-	-		QHG53763
OrthoDB	1	1.010	-	-		D122926at33208
OrthoFinder	1	1.000	-	-		FOG0003151
OrthoInspector	1	1.000	-	-		oto40970
orthoMCL	1	0.900	-	-		OOG6_101404
Panther	1	1.100	-	-	LDO	PTHR19876
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840