DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FarO and FAR1

DIOPT Version :9

Sequence 1:	NP_652021.1	Gene:	FarO / 45707	FlyBaseID:	FBgn0023550	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_011518702.1	Gene:	FAR1 / 84188	HGNCID:	26222	Length:	518	Species:	Homo sapiens

Alignment Length:	517	Identity:	147/517 - (28%)
Similarity:	257/517 - (49%)	Gaps:	61/517 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EFFEDSEIFVTGGSGVVGKALVEKLLRSC-NVRRIYVLLRPRKQLTAEQRLVRLRQATVFHVLAV 74
            |::|...:.:||.:|.:||.|:||||||| .|..:|||:|.:...|.::|:..:....:|..|..
Human     6 EYYEGKNVLLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEVLSGKLFDRLRD 70

  Fly    75 QKPEELDKIVAVPGDVSLPGLGI---DPSMMQRMKGVSLVYHCAATVRFDEPLREAVRLNVGGTL 136
            :.|:..:||:|:..:::.|.|.:   |..::  :...::::||||||||:|.||:||:|||..|.
Human    71 ENPDFREKIIAINSELTQPKLALSEEDKEVI--IDSTNIIFHCAATVRFNENLRDAVQLNVIATR 133

  Fly   137 EALKFAETLPQLRAFIHVSTFYSNPYLTRVEPKYYSSPMDWRLCLRMIDDV--ADDGMLNALTRK 199
            :.:..|:.:..|..|:||||.|:......::...|..|:|.:   ::||.:  .|||::|.:|.|
Human   134 QLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPK---KLIDSLEWMDDGLVNDITPK 195

  Fly   200 LIMGFPNTYTFTKNLAESLVNDYRHRLPVIVYRPSIVLFAVEDPSPGFSPSLMGAMGLFALVGAG 264
            ||...||||.:||.|||.:|.....:|.|.:.|||||..:.::|.||:..:..|..|||...|.|
Human   196 LIGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKG 260

  Fly   265 ILKTVYLGKDIRLDITPQDIGIKSMLC---YTKMGYDIYRQGPPADLPVFLSSSCT--------- 317
            ||:|:....:...|:.|.|:.:...|.   |:  |.:.|.:  |.::.|:   :||
Human   261 ILRTIRASNNALADLVPVDVVVNMSLAAAWYS--GVNRYMR--PRNIMVY---NCTTGSTNPFHW 318

  Fly   318 -----HVPHTFTQ-IAEQMDTLDLWRDVAFEKNLMIPGCHYTDKRWAYQFLVFTKQILPALILDL 376
                 ||..||.: ..||          ||.:    |..:.|.....|.:.:......||.:.|:
Human   319 GEVEYHVISTFKRNPLEQ----------AFRR----PNVNLTSNHLLYHYWIAVSHKAPAFLYDI 369

  Fly   377 LLRIFGQKPVLMSAVRKAYQTLEVMQPFMFNN--WDSPGVSDMETLSKHGEGSAFNFDAFNHPDI 439
            .||:.|:.|.:|..:.:.::.:..::.|..|:  |::..|:.:.......:...||.|.   ..:
Human   370 YLRMTGRSPRMMKTITRLHKAMVFLEYFTSNSWVWNTENVNMLMNQLNPEDKKTFNIDV---RQL 431

  Fly   440 HGLVIQSCSNMLHSIRTHLLREDPKTLERSKRILRIKVFLYRLLRLFLLYKLILWLWRSYLA 501
            |.  .:...|.....:.::|.|:...|..:::.|.    ..|.:|......|::.:||.::|
Human   432 HW--AEYIENYCLGTKKYVLNEEMSGLPAARKHLN----KLRNIRYGFNTILVILIWRIFIA 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FarO	NP_652021.1	FAR-N_SDR_e	18..328	CDD:187547	111/333 (33%)
FarO	NP_652021.1	FAR_C	379..>410	CDD:296071	6/32 (19%)
FAR1	XP_011518702.1	PLN02996	2..449	CDD:215538	137/473 (29%)
		FAR-N_SDR_e	11..333	CDD:187547	111/333 (33%)
		Sterile	360..450	CDD:281068	17/94 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157518
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100550
Panther	1	1.100	-	-	O	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.750