Protein Alignment FarO and Far1

DIOPT Version :10

• Sequence 1: NP_652021.1
• Gene: FarO / 45707
• FlyBaseID: FBgn0023550
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001011933.1
• Gene: Far1 / 293173
• RGDID: 1306647
• Length: 515
• Species: Rattus norvegicus
• Alignment Length: 520
• Identity: 154/520 - (29%)
• Similarity: 262/520 - (50%)
• Gaps: 70/520 - (13%)

  Fly    11 EFFEDSEIFVTGGSGVVGKALVEKLLRSC-NVRRIYVLLRPRKQLTAEQRLVRLRQATVFHVLAV 74
            |::|...|.:||.:|.:||.|:||||||| .|..:|||:|.:...|.::|:..:....:|..|..
  Rat     6 EYYEGKNILLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEILSGKLFDRLRD 70

  Fly    75 QKPEELDKIVAVPGDVSLPGLGI---DPSMMQRMKGVSLVYHCAATVRFDEPLREAVRLNVGGTL 136
            :.|:...||:|:..:::.|.|.:   |..::  :...::::||||||||:|.||:||:|||..|.
  Rat    71 ENPDFRQKIIAINSELTQPKLALSEEDKEII--IDSTNVIFHCAATVRFNENLRDAVQLNVIATR 133

  Fly   137 EALKFAETLPQLRAFIHVSTFYSNPYLTRVEPKYYSSPMDWRLCLRMIDDV--ADDGMLNALTRK 199
            :.:..|:.:..|..|:||||.|:......::...|..|:|.:   ::||.:  .|||::|.:|.|
  Rat   134 QLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPK---KLIDSLEWMDDGLVNDITPK 195

  Fly   200 LIMGFPNTYTFTKNLAESLVNDYRHRLPVIVYRPSIVLFAVEDPSPGFSPSLMGAMGLFALVGAG 264
            ||...||||.:||.|||.:|.....:|.|.:.|||||..:.::|.||:..:..|..|||...|.|
  Rat   196 LIGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKG 260

  Fly   265 ILKTVYLGKDIRLDITPQDIGIKSMLC---YTKMGYDIYRQGPPADLPVFLSSSCT--------- 317
            ||:|:....:...|:.|.|:.:.:.|.   |:.:       ..|.::.|:   :||
  Rat   261 ILRTMRASNNALADLVPVDVVVNTSLAAAWYSGV-------NRPRNIMVY---NCTTGSTNPFHW 315

  Fly   318 -----HVPHTF-TQIAEQMDTLDLWRD--VAF-EKNLMIPGCHYTDKRWAYQFLVFTKQILPALI 373
                 ::.|:| |....|     ::|.  |.| ..|||:   ||    |.     ..|..:|||:
  Rat   316 GEVGDYLNHSFKTNPLNQ-----VFRHPYVKFYSNNLML---HY----WK-----GVKHTVPALL 363

  Fly   374 LDLLLRIFGQKPVLMSAVRKAYQTLEVMQPFMFNN--WDSPGVSDMETLSKHGEGSAFNFDAFNH 436
            |||.||:.||||.:|..:.:.::.:..::.|..|:  |::..|:.:.......:...||.|.
  Rat   364 LDLALRLTGQKPWMMKTITRLHKAMVFLEYFTSNSWVWNTDNVNMLMNQLNPEDKKTFNIDV--- 425

  Fly   437 PDIHGLVIQSCSNMLHSIRTHLLREDPKTLERSKRILRIKVFLYRLLRLFLLYKLILWLWRSYLA 501
            ..:|.  .:...|.....:.::|.|:...|..:::.|.    ..|.:|......|::.:||.::|
  Rat   426 RQLHW--AEYIENYCMGTKKYVLNEEMSGLPAARKHLN----KLRNIRYGFNTILVILIWRIFIA 484

  Fly   502  501
              Rat   485  484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FarO	NP_652021.1	FAR-N_SDR_e	18..328	CDD:187547	109/333 (33%)
		Sterile	379..>410	CDD:460779	8/32 (25%)
Far1	NP_001011933.1	FAR-N_SDR_e	11..330	CDD:187547	109/333 (33%)
		Sterile	371..447	CDD:460779	14/80 (18%)
		Necessary and sufficient for PEX19-mediated localization into peroxisome membrane. /evidence=ECO:0000250|UniProtKB:Q8WVX9	451..507		8/38 (21%)