DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and CYP4F2

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens

Alignment Length:	519	Identity:	177/519 - (34%)
Similarity:	271/519 - (52%)	Gaps:	50/519 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLATALAWDY------MRKR------RHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFD 61
            |||..|||.|      .|.|      |.|..:...|               ::|.:.:....:
Human    30 LLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQG---------------MVNPTEEGMRVL-- 77

  Fly    62 MQFRLIAEFGKNIKTQMLGESGFMT-ADSKMIEAIMSSQQTIQKNN--LYSLLVNWLGDGLLISQ 123
              .:|:|.:.:..|..|...|..:: ....:|.:::::...|...:  .||.|..|||||||:|.
Human    78 --TQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSA 140

  Fly   124 GKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRA-DGKTVINMFPVACLCAMDIIAE 187
            |.||.|.|:::||||||.||:.::::|::....|..|....| :|...::||....|..:|.:.:
Human   141 GDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQK 205

  Fly   188 TAMGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFY--PKLLDKLNDAVKNMHD 250
            .......:.|.:|. .|:.::...||::::|....|..:||   |:|  |. ..:...|.:.:||
Human   206 CVFSFDSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDF---LYYLTPD-GQRFRRACRLVHD 265

  Fly   251 FTNSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKS-TIDGAPLSNDDIREEVDT 314
            ||::||.|||..|.....|.      .|....:.:.:..:||||.| ..||..||::|||.|.||
Human   266 FTDAVIQERRRTLPSQGVDD------FLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADT 324

  Fly   315 FMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESL 379
            |||||||||.|.:::..|.||:|||.|.|..|||::::.|.:...:....|..|.:|...:||||
Human   325 FMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESL 389

  Fly   380 RLFPSVPIIGRYISQDTVL-DGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEIS 443
            ||.|.||:|.|:::||.|| ||::||.....:|.::....:|..:||||.:.|.||..|...|.|
Human   390 RLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERS 454

  Fly   444 PFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQPVLNVILRSTTGINCGLKP 507
            |.|:.||||||||||||.|||.|||..::..:..|.:||...|.:....::||:..|:...::|
Human   455 PLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	161/462 (35%)
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	9/26 (35%)
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	167/492 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154778
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750