Protein Alignment Cyp4d14 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_001259179.1
• Gene: Cyp4d14 / 45706
• FlyBaseID: FBgn0023541
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 129/562 - (22%)
• Similarity: 225/562 - (40%)
• Gaps: 120/562 - (21%)

  Fly    32 GIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFRLIAEFGKNIKTQMLGESGFMT-ADSKMIEAI 95
            |:|.||..|.:||....       :...::.|..|...:|. :....||...|:. ::..||:.:
Human    43 GLRHPKPSPFIGNLTFF-------RQGFWESQMELRKLYGP-LCGYYLGRRMFIVISEPDMIKQV 99

  Fly    96 MSSQQTIQKNNLYS-LLVNWLGDGLLISQGKKWFRRRKIITPAF--------------------- 138
            :....:...|.:.| |....:.|.:|..:.|:|...|..:..||
Human   100 LVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNELGLLIMQERIKGHM 164

  Fly   139 ------------------------HFKILE-DFVEVFDQQSATMVQKLYDRADGKTVINMFPVAC 178
                                    |:..|. ..|.:..|....::..|...|:.....::....|
Human   165 GGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMVPLISQACDLLLAHLKRYAESGDAFDIQRCYC 229

  Fly   179 LCAMDIIAETAMGVKINAQLQPQFTYVQSVTTASAMLAERFMN-PLQRLDFTMKLFYPKLLDKLN 242
            ....|::|..|.|..:::...|:..:|:.        .:||.. .:.|....:.|.:|.::..|.
Human   230 NYTTDVVASVAFGTPVDSWQAPEDPFVKH--------CKRFFEFCIPRPILVLLLSFPSIMVPLA 286

  Fly   243 DAVKN-----MHDFTNSVI-------------TERRELLQKAI------ADGGDADAALLNDV-- 281
            ..:.|     ::.|.|.:|             ..||:.||..:      :..|..|..::.||
Human   287 RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFS 351

  Fly   282 -----------GQKRRMALLDVLLKSTIDGAPLSNDDIREEVDTFMFEGHDTTTSSIAFTCYLLA 335
                       .|...||            .||:.|:|..:...|:..|::..|::::|..||||
Human   352 STGCKPNPSRQHQPSPMA------------RPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLA 404

  Fly   336 RHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLRLFPSVPIIGRYISQDTVLDG 400
            .:|:.|.::.:|| ||..:...||....|...|.||:.||.|:||::|......|..:||..:.|
Human   405 TNPDCQEKLLREV-DVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLG 468

  Fly   401 KLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEISPFAYTPFSAGPRNCIGQKFAML 465
            :.|||.:.:.:.:.....||:::|.||.|.|:||:.|.:.:..||.|.||.||||:|:|.:..:|
Human   469 QRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLL 533

  Fly   466 EMKSTISKMVR--HFELLPLGEEVQPVLNVILRSTTGINCGL 505
            |:|.|:..::.  .|:..|   |.|..|.:..:|..|...|:
Human   534 EVKLTLLHVLHKFRFQACP---ETQVPLQLESKSALGPKNGV 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	CYP4	71..503	CDD:410721	119/519 (23%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	120/525 (23%)