DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001093657.1	Gene:	Cyp4f37 / 677156	MGIID:	3780112	Length:	546	Species:	Mus musculus

Alignment Length:	511	Identity:	163/511 - (31%)
Similarity:	263/511 - (51%)	Gaps:	34/511 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFRLIAEFGKN 73
            :||..|||.|......:::  ....:.||....:|:..::.:.         :...:|:.|.|:.
Mouse    30 ILARILAWTYSFCENCSRL--RCFPQPPKRNWFLGHLGMIEHN---------EEGMQLMTEAGQT 83

  Fly    74 IKTQMLGESGFMTADSKMIE------AIMSSQQTIQKNNLYSLLVN-WLGDGLLISQGKKWFRRR 131
            .:...|...|.:....::::      .:::|.....|:..:...|. ||||||.::.|.||.|.|
Mouse    84 YRDVHLCWLGPVIPVLRIVDPAFVAPLLLASALVAPKDTTFHTFVKPWLGDGLFLNSGDKWSRHR 148

  Fly   132 KIITPAFHFKILEDFVEVFDQQSATMVQK-LYDRADGKTVINMFPVACLCAMDIIAETAMGVKIN 195
            :::||||||.||:.:|::|:|....|..| .:..::|...:.||....|..:|.:.:...|...|
Mouse   149 RLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLSSEGSARLEMFEHISLMTLDSLQKCLFGFDSN 213

  Fly   196 AQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLD--KLNDAVKNMHDFTNSVITE 258
            .|..|. .|:.::...|:::.:|.......:||   |:| ...|  :...|...:|:||::||.|
Mouse   214 CQESPS-EYISAILELSSLVIKRSHQLFLFVDF---LYY-HTADGRRFRKACDLVHNFTDAVIRE 273

  Fly   259 RRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTID-GAPLSNDDIREEVDTFMFEGHDT 322
            ||..|.....|      ..|....:.:.:..:||||.:..: |..||::|||.|.|||||.||||
Mouse   274 RRHTLSSQNHD------EFLKSKTKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDT 332

  Fly   323 TTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLRLFPSVPI 387
            |.|::::..|.||||||.|.|..|||::::...:...:....|.:|.:|...|||||||.|.|..
Mouse   333 TASALSWILYNLARHPEYQERCRQEVQELLRGREPQEIEWDDLAQLPFLTMCIKESLRLHPPVID 397

  Fly   388 IGRYISQDTVL-DGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEISPFAYTPFS 451
            :.|..::|.|| ||::||..:..:|.|:....:|..:||||.:.|.||..|...:..|.|:.|||
Mouse   398 LLRRCTRDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENAHKRPPLAFIPFS 462

  Fly   452 AGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQPVLNVILRSTTGINCGLKP 507
            |||||||||.|||.||...::..:..|.:||..:|.:....:|||:..|:...::|
Mouse   463 AGPRNCIGQTFAMNEMMVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	152/466 (33%)
Cyp4f37	NP_001093657.1	CYP4F	74..515	CDD:410772	153/451 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845184
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750