Protein Alignment Cyp4d14 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_001259179.1
• Gene: Cyp4d14 / 45706
• FlyBaseID: FBgn0023541
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 177/519 - (34%)
• Similarity: 265/519 - (51%)
• Gaps: 50/519 - (9%)

  Fly     9 LLATALAWDYM------------RKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFD 61
            |||..|||.|.            :..:.|..:...|:..|....|..:..:         |:.:.
Human    30 LLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKNSTQM---------SATYS 85

  Fly    62 MQFRLIAEFGKNIKTQMLGE--SGFMTADSKMIEAIMSSQQTI-QKNNLY-SLLVNWLGDGLLIS 122
            ..|           |..||.  ...:......|.:|.::...| .|:||: ..|..|||:|:|:|
Human    86 QGF-----------TVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLS 139

  Fly   123 QGKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRA-DGKTVINMFPVACLCAMDIIA 186
            .|.||.|.|:::||||||.||:.::.:|::.:..|:.|....| :|.:.::||....|..:|.:.
Human   140 GGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQ 204

  Fly   187 ETAMGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHDF 251
            :.......:.|.:|. .|:.::...||::.:|..:.||.:||...|.:..  .:.:.|.:.:|||
Human   205 KCIFSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSHDG--RRFHRACRLVHDF 266

  Fly   252 TNSVITERRELL-QKAIADGGDADAALLNDVGQKRRMALLDVLLKS-TIDGAPLSNDDIREEVDT 314
            |::||.|||..| .:.|.|       ...|..:.:.:..:||||.| ..||..||::|||.|.||
Human   267 TDAVIRERRRTLPTQGIDD-------FFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADT 324

  Fly   315 FMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESL 379
            |||.|||||.|.:::..|.||||||.|.|..|||::::.|.....:....|.:|.:|...:||||
Human   325 FMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESL 389

  Fly   380 RLFPSVPIIGRYISQDTVL-DGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEIS 443
            ||.|..|.|.|..:||.|| ||::||.....:|.|.....:|..:||||.:.|.||..|.....|
Human   390 RLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRS 454

  Fly   444 PFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQPVLNVILRSTTGINCGLKP 507
            |.|:.||||||||||||.|||.|||..::.|:.||..||...|.:..|.:|:|:..|:...::|
Human   455 PLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEP 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	CYP4	71..503	CDD:410721	163/439 (37%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	166/470 (35%)