Protein Alignment Cyp4d14 and CYP3A43

DIOPT Version :10

• Sequence 1: NP_001259179.1
• Gene: Cyp4d14 / 45706
• FlyBaseID: FBgn0023541
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 141/533 - (26%)
• Similarity: 246/533 - (46%)
• Gaps: 78/533 - (14%)

  Fly     8 ILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFRLIAEFGK 72
            :|:||:|...|:.....:|::.:.||.||...|.:|.....:.       .:::.......::|
Human    13 VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLR-------GLWNFDRECNEKYG- 69

  Fly    73 NIKTQMLG-----ESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVN--------WLGDGLLISQG 124
                :|.|     :...:..|..||:.::..:       .||:..|        :|...|..::.
Human    70 ----EMWGLYEGQQPMLVIMDPDMIKTVLVKE-------CYSVFTNQMPLGPMGFLKSALSFAED 123

  Fly   125 KKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETA 189
            ::|.|.|.:::|||.....::.|.:..|....:|:.|...|:....||:........||:|..|.
Human   124 EEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTL 188

  Fly   190 MGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAV--KNMHDFT 252
            .||.:::...||..:::::   ..:|...|::|...| .::..|...:.:.||..:  |::..|.
Human   189 FGVNLDSLNNPQDPFLKNM---KKLLKLDFLDPFLLL-ISLFPFLTPVFEALNIGLFPKDVTHFL 249

  Fly   253 NSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLL-----KSTIDGAPLSNDDIREEV 312
            .:.|...:|              :.|.| .||.|:.....::     |.|.....||:.::..:.
Human   250 KNSIERMKE--------------SRLKD-KQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 299

  Fly   313 DTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKE 377
            ...:|..:|||::::.|..|.||.||:||.::.:|:..|:  ...||||...|.:::||:.|:.|
Human   300 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL--PNKAPVTYDALVQMEYLDMVVNE 362

  Fly   378 SLRLFPSVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPD-RFSMERKGE 441
            :|||||.|..:.|...:|..::|..||....|::.||....||.|:.:||||.|: |||.:.|..
Human   363 TLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDS 427

  Fly   442 ISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEE-----------VQP----VL 491
            |..:.|.||.||||||||.:||:..:|..:.:.:::|...|..|.           :||    ||
Human   428 IDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVL 492

  Fly   492 NVILRSTTGINCG 504
            .|.||.  ||..|
Human   493 KVHLRD--GITSG 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	CYP4	71..503	CDD:410721	128/467 (27%)
CYP3A43	NP_073731.1	cytochrome_P450	67..493	CDD:477761	122/458 (27%)