DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d14 and CYP4F11

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001122404.1	Gene:	CYP4F11 / 57834	HGNCID:	13265	Length:	524	Species:	Homo sapiens

Alignment Length:	522	Identity:	179/522 - (34%)
Similarity:	269/522 - (51%)	Gaps:	56/522 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLATALAWDYM------------RKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFD 61
            |||..|||.|.            :..:.|..:...|:..|            ..|..|:.:
Human    30 LLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTP------------TEEGMKTLT---- 78

  Fly    62 MQFRLIAEFGKNIKTQMLGESG--FMTADSKMIEAIMSSQQTIQKNNL--YSLLVNWLGDGLLIS 122
               :|:..:.:..|. .||.:.  .:.....:|..|.|:...:...::  |..|..|||||||:|
Human    79 ---QLVTTYPQGFKL-WLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLS 139

  Fly   123 QGKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDR--ADGKTVINMFPVACLCAMDII 185
            .|.||.|.|:::||||||.||:.::::|: :|..::...:.|  ::|...::||....|..:|.:
Human   140 GGDKWSRHRRMLTPAFHFNILKPYMKIFN-KSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSL 203

  Fly   186 AETAMGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFY--PKLLDKLNDAVKNM 248
            .:.....:.|.|.:|. .|:.::...||.:.:|....|...||   |:|  |. ..:...|...:
Human   204 QKCVFSFESNCQEKPS-EYIAAILELSAFVEKRNQQILLHTDF---LYYLTPD-GQRFRRACHLV 263

  Fly   249 HDFTNSVITERR-ELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKS-TIDGAPLSNDDIREE 311
            ||||::||.||| .|..:.|.|       .|.:..:.:.:..:||||.| ..||..||::|||.|
Human   264 HDFTDAVIQERRCTLPTQGIDD-------FLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAE 321

  Fly   312 VDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIK 376
            .|||||||||||.|.:::..|.||:|||.|.:..|||::::.|.:...:....|.:|.:|...||
Human   322 ADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIK 386

  Fly   377 ESLRLFPSVPIIGRYISQDTVL-DGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKG 440
            |||||.|.||:|.|..:||.|| ||::||.....:|.|.....:|..:||||.:.|.||..|...
Human   387 ESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIK 451

  Fly   441 EISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQPVLNVILRSTTGINCGL 505
            |.||.|:.||||||||||||.|||.|||..::..:.||.:||...|.:....:|||:..|:...:
Human   452 ERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELILRAEGGLWLRV 516

  Fly   506 KP 507
            :|
Human   517 EP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	165/465 (35%)
CYP4F11	NP_001122404.1	p450	52..506	CDD:365848	167/486 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154766
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750