Protein Alignment Cyp4d14 and Cyp3a25

DIOPT Version :10

• Sequence 1: NP_001259179.1
• Gene: Cyp4d14 / 45706
• FlyBaseID: FBgn0023541
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_062766.2
• Gene: Cyp3a25 / 56388
• MGIID: 1930638
• Length: 503
• Species: Mus musculus
• Alignment Length: 536
• Identity: 144/536 - (26%)
• Similarity: 245/536 - (45%)
• Gaps: 83/536 - (15%)

  Fly     8 ILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFRL----IA 68
            :||.|:|...|:.....:.::.:.||.|||..||:|.   :.|        .:|..::.    ..
Mouse    13 VLLVTSLVLFYIYGTYSHGLFKKLGIPGPKPLPLLGT---IFN--------YYDGMWKFDEDCYK 66

  Fly    69 EFGKNIKTQMLGESGFMTADSKMIEAIMSSQ--QTIQKNNLYSLLVN--------WLGDGLLISQ 123
            ::||        ..||......:: |||..:  :.:.....||:..|        ::...:.||:
Mouse    67 KYGK--------IWGFYEGPQPIL-AIMDPEIIKIVLVKECYSVFTNRRFFGPVGFMKKAITISE 122

  Fly   124 GKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAET 188
            .::|.|.|.:::|.|....|::...:..|....:|:.|....:....|:|..:....:||:|..|
Mouse   123 DEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPISMKDIFGAYSMDVITGT 187

  Fly   189 AMGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLN------DAVKN 247
            :.||.:::...||..:||.   |..:|..:..:|. .|...:..|...:.:.||      |::..
Mouse   188 SFGVNVDSLNNPQDPFVQK---AKKILKFKIFDPF-LLSIILFPFLTPIYEMLNFSIFPRDSMNF 248

  Fly   248 MHDFTNSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSNDDIREEV 312
            ...|...:..||....||...|.........|..||:.:.||.|:              ::..:.
Mouse   249 FKKFVKRMKKERLASNQKNRVDFLQLMMNTQNSKGQESQKALSDL--------------EMAAQA 299

  Fly   313 DTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKE 377
            ..|:|.|:|.|::||:...|.||.||:||.::..|:...:  ...||||...|.:::||:.|:.|
Mouse   300 VIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTL--PNKAPVTYDALMDMEYLDMVVNE 362

  Fly   378 SLRLFPSVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEI 442
            ||||:|....:.|...:|..::|..||..:.|:|.||...|:|:|:|:|::|.|:|||.|.||.|
Mouse   363 SLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNI 427

  Fly   443 SPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQP---------------VLN 492
            .|:.|.||..|||||||.:||::.:|..:..::::|.:.|..|...|               :|.
Mouse   428 DPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLKISREPIFQPEKPIILK 492

  Fly   493 VILRSTTGINCGLKPR 508
            |:.|.        |||
Mouse   493 VVSRD--------KPR 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	CYP4	71..503	CDD:410721	126/462 (27%)
Cyp3a25	NP_062766.2	CYP3A	67..492	CDD:410743	123/453 (27%)