DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	513	Identity:	207/513 - (40%)
Similarity:	305/513 - (59%)	Gaps:	35/513 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILLATALAWDYMRK--RRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFRLIAEF 70
            :||..:.|::.::.  .:.|:|....|:.|  :||::|||       .:.|::..|...::|...
Zfish    19 LLLLASTAYNPLKNYIGKWNEMRPIPGMAG--AYPIIGNA-------LQFKTNAGDFFNQIIEGT 74

  Fly    71 GKN----IKTQMLGESGFMTA-DSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGLLISQGKKWFRR 130
            .:|    :....:|...|:.. .::.||.::|:.:.:.|:..|..|..|||.|||.|.|:||..|
Zfish    75 NENRHLPLAKVWVGPVPFLILYHAENIEVVLSNSRHLDKSYSYRFLHPWLGTGLLTSTGEKWRNR 139

  Fly   131 RKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETAMGVKIN 195
            ||::||.|||.||.||:||.::|:..::||:....||:. .|.|....|||:|||.|||||.||.
Zfish   140 RKMLTPTFHFSILSDFLEVMNEQTDILIQKMQKLEDGEP-FNCFNFITLCALDIICETAMGKKIY 203

  Fly   196 AQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDA--VKNMHDFTNSVITE 258
            ||......|||||...|.::.:|...|....|:    .|.||.:....|  :|.:|.||.:||.|
Zfish   204 AQSNADSEYVQSVYKMSDIITKRQRAPWLWPDW----IYNKLKEGKEHAKRLKILHSFTANVIRE 264

  Fly   259 RRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTID-GAPLSNDDIREEVDTFMFEGHDT 322
            |.|.:    :...|:|    :|.|:::|.|.||:|||:|.: |..||::||:|||||||||||||
Zfish   265 RAEFM----SSEPDSD----SDQGERKRQAFLDMLLKTTYENGQKLSHEDIQEEVDTFMFEGHDT 321

  Fly   323 TTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLRLFPSVPI 387
            |.:|:.:..:|:..|||||..|..|:::|.|..: ..|.::.|.:|:|||||||||||:|||||:
Zfish   322 TAASMNWALHLIGSHPEVQKAVQAELQEVFGSSE-RHVGVEDLKKLRYLECVIKESLRIFPSVPL 385

  Fly   388 IGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEISPFAYTPFSA 452
            ..|.|.:...::|..:|...|.:|:.|...|||.|||:||:|.|:||..|......|:||.||||
Zfish   386 FARSICEACHINGFKVPKGVNAVIIPYALHRDPRYFPEPEEFQPERFMPENSKGRHPYAYIPFSA 450

  Fly   453 GPRNCIGQKFAMLEMKSTISKMVRHF--ELLPLGEEVQPVLNVILRSTTGINCGLKPR 508
            ||||||||:|||:|.|..::.::|||  |.....||::|:..:|||...||...|:.|
Zfish   451 GPRNCIGQRFAMMEEKVVLATILRHFDVEACQSREELRPLGELILRPEKGIWIKLQRR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	193/464 (42%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	200/483 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589847
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950