DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	496	Identity:	198/496 - (39%)
Similarity:	286/496 - (57%)	Gaps:	25/496 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 YMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFRLIAEFGKNIKTQM-LGE 81
            |:.|.:..|.....|    .::|.:|||...     ||....|........||..:...:: :|.
Zfish    33 YLHKWKELKPIPGIG----NTFPFIGNALQF-----KSNGDFFLQLVGYTTEFQNSPLLKIWIGP 88

  Fly    82 SGFMTA-DSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGLLISQGKKWFRRRKIITPAFHFKILED 145
            ..|:.. .::.:|.::::...|.|...|..|..|||.|||.|.|.||.||||::||.|||.||.:
Zfish    89 IPFLILFHAETVETVLNNPVHIDKAYAYQFLHPWLGTGLLTSTGDKWRRRRKMLTPTFHFSILTE 153

  Fly   146 FVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETAMGVKINAQLQPQFTYVQSVTT 210
            |:||.::|:..:::||..:| ||...|.|....|||:|||.|||||.:|.||......||::|..
Zfish   154 FLEVMNEQAEVLIEKLEKQA-GKGPFNCFSHITLCALDIICETAMGKRIYAQSNYDSEYVRTVYR 217

  Fly   211 ASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHDFTNSVITERRELLQKAIADGGDADA 275
            .|.::..|...|....||...  |.....:.|.::|.:|.||.|||.||.|.|....:|..
Zfish   218 MSDIITRRQRMPWYWPDFVYN--YVGEGREHNRSLKILHSFTESVINERAEYLSYVESDSE---- 276

  Fly   276 ALLNDVGQKRRMALLDVLLKS-TIDGAPLSNDDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPE 339
               :|.|.::|.|.||:|||: ..||..|::.||:||||||||||||||.:::.:..:||..|||
Zfish   277 ---SDQGMRKRRAFLDMLLKTKDEDGKMLTHKDIQEEVDTFMFEGHDTTAAAMNWAIHLLGSHPE 338

  Fly   340 VQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLRLFPSVPIIGRYISQDTVLDGKLIP 404
            ||.:..||:.:|.|:.: .||..:.|.:|:|||||||||||||||||...|.|..||.::|..:|
Zfish   339 VQRKAQQELFEVFGESE-RPVNTEDLKKLRYLECVIKESLRLFPSVPFFARTICDDTQINGFKVP 402

  Fly   405 ADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKS 469
            ..:|::::.|...|||.:|||||:|.|:||..|......|:||.|||||.||||||:||::|.|.
Zfish   403 KGTNIVVITYALHRDPRFFPDPEEFRPERFLPENCVGRHPYAYIPFSAGLRNCIGQRFAIMEEKV 467

  Fly   470 TISKMVRHFELLPL--GEEVQPVLNVILRSTTGINCGLKPR 508
            .::.::|:|.::..  .||::|:..::||...||...|:.|
Zfish   468 ILAYILRYFNIVACQKREELRPLGELVLRPEQGIWITLERR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	187/459 (41%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	191/476 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589835
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.850