DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d14 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	540	Identity:	134/540 - (24%)
Similarity:	245/540 - (45%)	Gaps:	92/540 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILLATAL----AWDYMRKRRHNKMYAEAGIRGPKSYPLVGN----APLLINESPKSKSSIFDMQF 64
            :|:.|.|    .|.:       :.:.:.||.||:.:|.||.    |..|.|         |||:
Zfish    15 VLVITLLFIYGVWPH-------RFFIKLGIPGPRPWPFVGTLLSYAKGLCN---------FDME- 62

  Fly    65 RLIAEFGK-----NIKTQMLGESGFMTADSKMIEAIMSSQ---QTIQKNNLYSLLVNWLGDGLLI 121
             ...::||     :.:..:|     |.||.::|:.::..:   ..|.:....:.|.....||:::
Zfish    63 -CAKKYGKVWGIYDGRLPIL-----MVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSDGIIM 121

  Fly   122 SQGKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIA 186
            .:.::|.|.|..::|.|....|::...:....:...::.: .:.|.:..:.:..|....::|:|.
Zfish   122 VKDERWKRMRSTLSPYFTSGRLKEIFPIAMTHADRFIKNM-QKKDPEQPVKIKEVVAPYSLDVIT 185

  Fly   187 ETAMGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKL---LDKLNDAV--K 246
            .::..|.|::...|:..:|.:|   ...:.....|||    ..:.|.:|.|   |.|:...:  |
Zfish   186 SSSFSVDIDSINNPEDPFVINV---KKFIQFNMFNPL----LLLILLFPSLAIPLKKMGVTLFSK 243

  Fly   247 NMHDFTNSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSNDDIREE 311
            :..||..||:        |.|.|..:.::        :.|:..|.::|::.|....:.:.|..|:
Zfish   244 SAMDFFYSVL--------KKIKDDHNKES--------EGRVDFLKLMLQNQIPDDQIQDSDTSEQ 292

  Fly   312 -----VD--------TFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKS----AP 359
                 .|        .|:..|::||::::.|..|.||.:|:...::.:|:      ||:    .|
Zfish   293 PAKGLTDHEILSQSLVFILGGYETTSTTLTFLLYNLATNPDCLEKLVEEI------DKNFPLDTP 351

  Fly   360 VTMKLLGELKYLECVIKESLRLFPSVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFP 424
            :|...|..:.|||..|.||:||.|:.|.:.|...:..|::|..||..:.|.|..|....|||.:.
Zfish   352 ITYDALMRMDYLEMAINESMRLLPTAPRLERSAKKTVVINGLTIPEGTLVGIPTYVLSHDPDIWE 416

  Fly   425 DPEKFIPDRFSMERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQP 489
            .|.:|.|:|||.|.|.|...:|:.||..|||||||.::|::.||..:.|::::|.:....|...|
Zfish   417 SPGEFRPERFSPENKSEFLQYAFIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIP 481

  Fly   490 V-LNVILRSTTGINCGLKPR 508
            : :||..:....|...|.||
Zfish   482 LEMNVTFQPKVPITLKLIPR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	121/488 (25%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	122/492 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000