DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and cyp26c1

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001025122.2	Gene:	cyp26c1 / 554036	ZFINID:	ZDB-GENE-050714-2	Length:	554	Species:	Danio rerio

Alignment Length:	532	Identity:	120/532 - (22%)
Similarity:	204/532 - (38%)	Gaps:	126/532 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILLATALAWDY---MRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFRLIAE 69
            :|..:.|.|::   :.:.|..|:....|..|   :||||.....:     .:.|.|.:..|  .:
Zfish    25 LLAVSRLLWEFRWSITRDRTCKLPLPQGSMG---WPLVGETFHWL-----FQGSSFHISRR--EK 79

  Fly    70 FGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNW-------LGDGLLI-SQGKK 126
            .||..||.:||:.......::.|..|:..:.|:       :...|       ||...|: |.|..
Zfish    80 HGKVFKTHLLGKPLIRVTGAENIRKILLGEHTV-------VCTQWPQSTRIILGPNTLVNSVGDL 137

  Fly   127 WFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETAMG 191
            ..|:||::...|....||.::........:.:.|.......   :.::..|......|.....:|
Zfish   138 HKRKRKVLAKVFSRGALEAYLTRLQDVVKSEIAKWCTETGS---VEVYTAAKSLTFRIAVRVLLG 199

  Fly   192 VKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKN---MHDFTN 253
            :.:..|   |.||:...       .|:.||.|    |::.:..|  :..|...::.   :|....
Zfish   200 LHLEEQ---QITYLSKT-------FEQLMNNL----FSLPIDTP--VSGLRKGIRAREILHSAME 248

  Fly   254 SVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDG-APLSNDDIREEVDTFMF 317
            .:|.|:  |.::..:|..||                .|.:|.|..:. ..|:..:::|.....:|
Zfish   249 KIIEEK--LKKQQASDYCDA----------------FDYMLSSARENDYELTMQELKETAVELIF 295

  Fly   318 EGHDTTTSSIAFTCYLLARHPEV--QARVFQEVRDVIGD---------------------DKSAP 359
            ..|.||.|:.......|.|||:|  :||...|...:|.|                     :||..
Zfish   296 AAHSTTASASTSLIMQLLRHPDVSERARAELESEGLITDGHGHCRSRCNGNAISEEGEAAEKSTS 360

  Fly   360 -----------------------------VTMKLLGELKYLECVIKESLRLFPSVPIIGRY--IS 393
                                         ::::.|.:|.||:||:||.||..|  |:.|.|  :.
Zfish   361 DRRSAINKATYFEAGDKEEGRRSRTHVPYLSLEKLSQLSYLDCVVKEVLRFLP--PVSGGYRTVL 423

  Fly   394 QDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEISP-FAYTPFSAGPRNC 457
            |...|:|..||...:|:..|.......:.:.:||.|.||||.:.|:...|. |:|.||..|.|.|
Zfish   424 QTFELNGYQIPKGWSVMYSIRDTHETAEAYQNPELFDPDRFCVGREESKSERFSYVPFGGGVRRC 488

  Fly   458 IGQKFAMLEMKS 469
            ||::.|::.:|:
Zfish   489 IGRELALIVLKT 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	114/503 (23%)
cyp26c1	NP_001025122.2	p450	23..533	CDD:299894	120/532 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910