DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and Cyp4a1

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_787031.1	Gene:	Cyp4a1 / 50549	RGDID:	68945	Length:	509	Species:	Rattus norvegicus

Alignment Length:	415	Identity:	152/415 - (36%)
Similarity:	226/415 - (54%)	Gaps:	37/415 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 NNLYSLLVNWLGDGLLISQGKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKT 169
            |.:|.||..|:|.|||:..|:.||:.|:::|||||:.||:.:|:........|:.|....|...:
  Rat   116 NGVYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWEQLAGQDS 180

  Fly   170 VINMFPVACLCAMDIIAETAMGVKINAQLQPQF-TYVQSVTTASAMLAERFMNPLQRLD----FT 229
            .|.:|....|..:|.:.:.|.....:.|:...: :|:|::...:.:...|..|...:.|    |:
  Rat   181 SIEIFQHISLMTLDTVMKCAFSHNGSVQVDGNYKSYIQAIGNLNDLFHSRVRNIFHQNDTIYNFS 245

  Fly   230 MK--LFYPKLLDKLNDAVKNMHDFTNSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDV 292
            ..  ||        |.|.:..||.|:.||..|::.||.|    |:     |..|.:|||:..||:
  Rat   246 SNGHLF--------NRACQLAHDHTDGVIKLRKDQLQNA----GE-----LEKVKKKRRLDFLDI 293

  Fly   293 LLKSTID-GAPLSNDDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDK 356
            ||.:.:: |..||:.|:|.|||||||||||||.|.:::..|.||.|||.|.|..:||:.|:||..
  Rat   294 LLLARMENGDSLSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSVLGDGS 358

  Fly   357 SAPVTMKLLGELKYLECVIKESLRLFPSVPIIGRYISQD-TVLDGKLIPADSNVIILIYHAQRDP 420
            |  :|...|.::.|....|||:|||:|.||.|.|.:|.. |..||:.:|....|.:.||....:|
  Rat   359 S--ITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPKGIQVTLSIYGLHHNP 421

  Fly   421 DYFPDPEKFIPDRFSMERKGEISP---FAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLP 482
            ..:|:||.|.|.||:.:     ||   .::.|||.|.|||||::|||.|||..::..:..|||||
  Rat   422 KVWPNPEVFDPSRFAPD-----SPRHSHSFLPFSGGARNCIGKQFAMSEMKVIVALTLLRFELLP 481

  Fly   483 LGEEVQ-PVLNVILRSTTGINCGLK 506
            ...:|. |:..::|:|..||...||
  Rat   482 DPTKVPIPLPRLVLKSKNGIYLYLK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	145/396 (37%)
Cyp4a1	NP_787031.1	p450	52..503	CDD:278495	150/410 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348534
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850