DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d14 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_038935701.1	Gene:	Cyp4f40 / 503122	RGDID:	1559596	Length:	530	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	170/485 - (35%)
Similarity:	248/485 - (51%)	Gaps:	55/485 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 SPKSKSSIFDMQFRLIAEFGKNIKTQMLGESGFMT-----------ADSKMIEAIMSSQQTIQKN 105
            ||.::..:..|. .|:|.:          ..||||           ....:|.:::|:...:...
  Rat    67 SPPTEEGMKQMT-ELVATY----------PQGFMTWLGPIVPLITLCHPDIIRSVLSASAAVAPK 120

  Fly   106 N--LYSLLVNWLGDGLLISQGKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGK 168
            :  .||.|..|||||||:|...||.|.|.::||||||.||:.:|::|:..:..|..|....|.|.
  Rat   121 DGIFYSFLKPWLGDGLLVSASDKWSRHRSMLTPAFHFNILKPYVKIFNDSTNIMHAKWLRLASGG 185

  Fly   169 TV-INMFPVACLCAMDIIAETAMGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKL 232
            :. ::||....|..:|.:.:.......|.|.:|. .|:.::...||::.:|....|..:|...:|
  Rat   186 SAHLDMFENISLMTLDTLQKCVFSFNSNCQEKPS-EYIAAILELSALVVKRNEQLLLHMDLLYRL 249

  Fly   233 ------FYPKLLDKLNDAVKNMHDFTNSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLD 291
                  ||        .|...:||||.:||.|||..|.|   .|||   .::....:.:.:..:|
  Rat   250 TPDGRRFY--------KACHLVHDFTYAVIQERRRTLPK---HGGD---DVIKAKAKSKTLDFID 300

  Fly   292 VLLKS-TIDGAPLSNDDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDD 355
            |||.| ..||..||::|||.|.|||||||||||.|.:::..|.||:|||.|.|..|||::::.|.
  Rat   301 VLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDR 365

  Fly   356 KSAPVTMKL-------LGELKYLECVIKESLRLFPSVPIIGRYISQDTVL-DGKLIPADSNVIIL 412
            .|..:....       |.:|.:|...|||||||.|.|.::.|..:||..| ||::||.....||.
  Rat   366 DSEEIECSCGVLLRDDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQDISLPDGRVIPKGIICIIN 430

  Fly   413 IYHAQRDPDYFPDPEKFIPDRFSMERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRH 477
            |:....:|..:.|||.:.|.||..|.....||.|:.||||||||||||.|||.|||..::..:..
  Rat   431 IFATHHNPTVWQDPEVYDPFRFDPENIQARSPLAFIPFSAGPRNCIGQTFAMNEMKVAVALTLLR 495

  Fly   478 FELLPLGEEVQPVLNVILRSTTGINCGLKP 507
            |.:||..:|.:....:|||:..|:...::|
  Rat   496 FRVLPDDKEPRRKPELILRAEDGLWLRVEP 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	165/465 (35%)
Cyp4f40	XP_038935701.1	CYP4F	74..522	CDD:410772	167/473 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348634
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750