Protein Alignment Cyp4d14 and cyp-25A3

DIOPT Version :10

• Sequence 1: NP_001259179.1
• Gene: Cyp4d14 / 45706
• FlyBaseID: FBgn0023541
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001040850.1
• Gene: cyp-25A3 / 4363046
• WormBaseID: WBGene00014697
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 558
• Identity: 144/558 - (25%)
• Similarity: 254/558 - (45%)
• Gaps: 110/558 - (19%)

  Fly     2 YLELFAIL--LATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPK-SKSSIFDMQ 63
            :|.|.:||  |.:.:.:..:.::...::..:.|:.||:.:.|:||...:|....| .....:|..
 Worm     3 FLILTSILVSLVSFIIYVILARKERFRLRGKIGLSGPEPHWLMGNLKQIIERKAKLGYDDSYDWY 67

  Fly    64 FRLIAEFGKNIKTQMLGESGFMTADSKMIEAIM------SSQQT----IQKNNL-YSLLVNWLGD 117
            .:|..:||:........:......:.:.|:.:.      .|.:|    |:.|.| .|||.|....
 Worm    68 NKLHKQFGETFGIYFGTQLNINITNEEDIKEVFIKNFSNFSDRTPPPIIEDNKLKESLLQNTYES 132

  Fly   118 GLLISQGKKWFRRRKIITPAF------------HFKILEDFVEVFDQQSATMVQK--LYDRADGK 168
            |        |...|..|.|.|            |.|: :.|:|:. ::.|:..||  :||...|.
 Worm   133 G--------WKHTRSAIAPIFSTGKMKAMHETIHSKV-DLFLEIL-KEKASSGQKWDIYDDFQGL 187

  Fly   169 TVINMFPVACLCAMDIIAETAMGVKINAQL-QPQFTYVQSVTTASAMLAERFMNPL----QRLDF 228
            |            :|:|.:.|..:..|.|. :....||.         |.:|:..:    .::..
 Worm   188 T------------LDVIGKCAFAIDSNCQRDRNDVFYVN---------ARKFITNIDIRHSKIIS 231

  Fly   229 TMKLFYPKLLDKLNDAVKNMHDFTNSVITERRELLQKA---IADGGDADAALLNDVGQKRR---- 286
            |..||     .:|:...|.::.||:         |.||   :.:|       |.||.::||
 Worm   232 TSFLF-----PELSKLWKVLYRFTD---------LAKAEIPLVEG-------LADVYERRRGGEG 275

  Fly   287 ---MALLDVLLKSTID-GAPLSNDDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQE 347
               :.||.:||....| ..|::..::.|....|:..|::||::::.:..|||:::|.||.::::|
 Worm   276 SDSVDLLKLLLNREDDKSKPMTKQEVIENCFAFLLAGYETTSTAMTYCSYLLSKYPNVQQKLYEE 340

  Fly   348 VRDVIGDDKSAPVTMKLLGELKYLECVIKESLRLFPSVPII---GRYISQDTVLDGKLIPADSNV 409
            :.:.   .::..:|...:..:|||:.|.||:||.:|  |:|   .|...:|..:.|:..|..:.|
 Worm   341 IMEA---KENGGLTYDSIHNMKYLDYVYKETLRCYP--PVIHFSNRRCLKDITIRGQFYPKGAIV 400

  Fly   410 IILIYHAQRDPDYFPDPEKFIPDRF-SMERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISK 473
            :.|.:...|:|:.:..||:|.|:|| :.|.|.  |...:.||..|||.|:|.:||.:|.|:||:|
 Worm   401 VCLPHTVHRNPENWDSPEEFHPERFENWEEKS--SSLKWIPFGVGPRYCVGMRFAEMEFKTTIAK 463

  Fly   474 MVRHFELLPL-GE-EVQPVLN-VILRSTTGINCGLKPR 508
            ::..|||... || ::.|..| ||:|....:...||||
 Worm   464 LLDTFELKQFEGEADLIPDCNGVIMRPKDPVRLHLKPR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	CYP4	71..503	CDD:410721	124/479 (26%)
cyp-25A3	NP_001040850.1	CYP3A-like	73..495	CDD:410678	125/480 (26%)